In recent years, with the increase of natural disasters, wars, and terrorist incidents, etc., there are more and more researches on post-traumatic stress disorder (PTSD). This paper bases on the definition, pathogenic mechanism and related gene research of post-traumatic stress disorder. Mechanism, reviews the research status of post-traumatic stress disorder to improve people’s understanding of post-traumatic stress disorder, and prospect for future research.
KeywordsPost-TraumaticStress DisorderDRD2PTSD
American Psychiatric Association (1980) American Psychiatric Association Diagnostic and Statistical Manual. Washington DC.
Do, L.L.T.N. (2011) American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders (DSM-IV). Encyclopedia of Child Behavior and Development. Springer, Boston, MA, 84-85.．
American Psychiatric Association (2013) Diagnostic and Statistical Manual of Mental Disorders (DSM-5®). American Psychiatric Publication.
Bremner, J.D. (2007) Neuroimaging in Posttraumatic Stress Disorder and Other Stress-Related Disorders. Neuroimaging Clinics of North America, 17, 523-538. https://doi.org/10.1016/j.nic.2007.07.003
Pitman, R.K., Altman, B., Greenwald, E., et al. (1991) Psychiatric Complications during Flooding Therapy for Posttraumatic Stress Disorder. The Journal of Clinical Psychiatry, 52, 17-20.
Bremner, J.D., Staib, L.H., Kaloupek, D., et al. (1999) Neural Correlates of Exposure to Traumatic Pictures and Sound in Vietnam Combat Veterans with and without Posttraumatic Stress Disorder: A Positron Emission Tomography Study. Biological Psychiatry, 45, 806-816. https://doi.org/10.1016/S0006-3223(98)00297-2
Shin, L.M., Orr, S.P., Carson, M.A., et al. (2004) Regional Cerebral Blood Flow in the Amygdala and Medial Prefrontalcortex during Traumatic Imagery in Male and Female Vietnam Veterans with PTSD. Archives of General Psychiatry, 61, 168-176. https://doi.org/10.1001/archpsyc.61.2.168
Bocchio-Chiavetto, L., Miniussi, C., Zanardini, R., et al. (2008) 5-HTTLPR and BDNF Val66Met Polymorphisms and Response to rTMS Treatment in Drug Resistant Depression. Neuroscience Letters, 437, 130-134. https://doi.org/10.1016/j.neulet.2008.04.005
De Kloet, C.S., Vermetten, E., Geuze, E., et al. (2007) Elevated Plasma Corticotrophin-Releasing Hormone Levels in Veterans with Posttraumatic Stress Disorder. Progress in Brain Research, 167, 287-291. https://doi.org/10.1016/S0079-6123(07)67025-3
Strawn, J.R. and Geracioti Jr., TD. (2008) Noradrenergic Dysfunction and the Psychopharmacology of Posttraumatic Stress Disorder. Depression and Anxiety, 25, 260-271. https://doi.org/10.1002/da.20292
Li, M., Han, F. and Shi, Y.X. (2010) Experimental Study on Apoptosis of Neurons in the Locus Nucleus of Rats with PTSD. Chinese Journal of Histochemistry and Cytochemistry, No. 1, 15-19.
Ishibashi, K., Ishii, K., Oda, K., et al. (2010) Competition between 11C-Raclopride and Endogenous Dopamine in Parkinson’s Disease. Nuclear Medicine Communications, 31, 159-166. https://doi.org/10.1097/MNM.0b013e328333e3cb
Nikolaus, S., Antke, C., Beu, M., et al. (2010) Cortical GABA, Striatal Dopamine and Midbrain Serotonin as the Key Players in Compulsive and Anxiety Disorders-Results from in Vivo Imaging Studies. Reviews in the Neurosciences, 21, 119-140.
Hien, D.A., Jiang, H., Campbell, A.N.C., et al. (2009) Do Treatment Improvements in PTSD Severity Affect Substance Use Outcomes? A Secondary Analysis from a Randomized Clinical Trial in NIDA’s Clinical Trials Network. American Journal of Psychiatry, 167, 95-101.
Waraczynski, M., Salemme, J. and Farral, B. (2010) Brain Stimulation Reward Is Affected by D2 Dopamine Receptor Manipulations in the Extended Amygdala but Not the Nucleus Accumbens. Behavioural Brain Research, 208, 626-635. https://doi.org/10.1016/j.bbr.2010.01.009
Monakhov, M., Golimbet, V., Abramova, L., et al. (2008) Association Study of Three Polymorphisms in the Dopamine D2 Receptor Gene and Schizophrenia in the Russian Population. Schizophrenia Research, 100, 302-307.
Inglis, F.M. and Moghaddam, B. (1999) Dopaminergic Innervation of the Amygdala Is Highly Responsive to Stress. Journal of Neurochemistry, 72, 1088-1094.
Wei, W. and Luo, H. (2008) Study Overview on the Etiology and Pathogenesis of Tardive Dyskinesia. Youjiang Medical Journal, 36, 624-625.
Esposito-Smythers, C., Spirito, A., Rizzo, C., et al. (2009) Associations of the DRD2 TaqIA Polymorphism with Impulsivity and Substance Use: Preliminary Results from a Clinical Sample of Adolescents. Pharmacology Biochemistry and Behavior, 93, 306-312. https://doi.org/10.1016/j.pbb.2009.03.012
Segman, R.H., Cooper-Kazaz, R., Macciardi, F., et al. (2002) Association between the Dopamine Transporter Gene and Posttraumatic Stress Disorder. Molecular Psychiatry, 7, 903. https://doi.org/10.1038/sj.mp.4001085
Klein, B., Mitchell, J., Gilson, K., et al. (2009) A Therapist-Assisted Internet-Based CBT Intervention for Posttraumatic Stress Disorder: Preliminary Results. Cognitive Behaviour Therapy, 38, 121-131. https://doi.org/10.1080/16506070902803483
Hou, F.S., Ting, L.I., Juan, L.I., et al. (2011) The Effects of Demographic Features on Differences in Sensitivity between PCL-C and SCL-90 Scores in a Follow-Up Study in Secondary School Students in the Wenchuan Earthquake Region. Biomedical and Environmental Sciences, 24, 642-648.
Wang, Z., Tang, Y. and Shi, S. (2006) Status Quo of Domestic Research on PTSD. Shanghai Archives of Psychiatry, 18, 372-374.
Liu, Y., Garrett, M.E., Dennis, M.F., et al. (2015) An Examination of the Association between 5-HTTLPR, Combat Exposure, and PTSD Diagnosis among US Veterans. PLoS ONE, 10, e0119998.
Kimbrel, N.A., Morissette, S.B., Meyer, E.C., et al. (2015) Effect of the 5-HTTLPR Polymorphism on Posttraumatic Stress Disorder, Depression, Anxiety, and Quality of Life among Iraq and Afghanistan Veterans. Anxiety, Stress, & Coping, 28, 456-466. https://doi.org/10.1080/10615806.2014.973862
Pietrzak, R.H., Galea, S., Southwick, S.M., et al. (2013) Examining the Relation between the Serotonin Transporter 5-HTTPLR Genotype x Trauma Exposure Interaction on a Contemporary Phenotypic Model of Posttraumatic Stress Symptomatology: A Pilot Study. Journal of Affective Disorders, 148, 123-128. https://doi.org/10.1016/j.jad.2012.11.003
Van Zuiden, M., Geuze, E., Willemen, H.L.D.M., et al. (2012) Glucocorticoid Receptor Pathway Components Predict Posttraumatic Stress Disorder Symptom Development: A Prospective Study. Biological Psychiatry, 71, 309-316. https://doi.org/10.1016/j.biopsych.2011.10.026
van Zuiden, M., Kavelaars, A., Geuze, E., et al. (2013) Predicting PTSD: Pre-Existing Vulnerabilities in Glucocorticoid-Signaling and Implications for Preventive Interventions. Brain, Behavior, and Immunity, 30, 12-21.
Nelson, E.C., Agrawal, A., Pergadia, M.L., et al. (2009) Association of Childhood Trauma Exposure and GABRA2 Polymorphisms with Risk of Posttraumatic Stress Disorder in Adults. Molecular Psychiatry, 14, 234. https://doi.org/10.1038/mp.2008.81
Freeman, T., Roca, V., Guggenheim, F., et al. (2005) Neuropsychiatric Associations of Apolipoprotein E Alleles in Subjects with Combat-Related Posttraumatic Stress Disorder. The Journal of Neuropsychiatry and Clinical Neurosciences, 17, 541-543. https://doi.org/10.1176/jnp.17.4.541