Enhancing Accumulation and Penetration Efficiency of Next-Generation Antibiotics to Mitigate Antibiotic Resistance in <i>Pseudomonas aeruginosa</i> PAO1 — Oak Academic Publishing
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Enhancing Accumulation and Penetration Efficiency of Next-Generation Antibiotics to Mitigate Antibiotic Resistance in <i>Pseudomonas aeruginosa</i> PAO1
Department of Chemical, Chemistry and Biomedical Engineering, University of New Haven, West Haven, USA
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Chemistry and Biochemistry, University of Toledo, Toledo, USA
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Department of Chemical, Chemistry and Biomedical Engineering, University of New Haven, West Haven, USA
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Department of Cell and Molecular Biology, University of New Haven, West Haven, USA
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Department of Cell and Molecular Biology, University of New Haven, West Haven, USA
This study explores the efficacy of advanced antibiotic compounds against P. aeruginosa, focusing on Antibiotic B, an enhanced derivative of Ceftriaxone. The study measured the intracellular uptake of Antibiotic B and introduced a novel adjuvant, Influximax, which augmented its antibacterial activity. Results showed a diminished potential for resistance emergence with Antibiotic B, particularly when used in combination with Influximax. The study suggests that optimizing antibiotic delivery into bacterial cells and leveraging syner-gistic adjuvant combinations can enhance drug resistance combat.
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