Using Cross Entropy as a Performance Metric for Quantifying Uncertainty in DNN Image Classifiers: An Application to Classification of Lung Cancer on CT Images — Oak Academic Publishing
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Using Cross Entropy as a Performance Metric for Quantifying Uncertainty in DNN Image Classifiers: An Application to Classification of Lung Cancer on CT Images
Faculty of Informatics, University of Fukuchiyama, Kyoto, Japan
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Graduate School of Radiological Sciences, International University of Health and Welfare, Tochigi, Japan
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School of Health Sciences, Fukushima Medical University, Fukushima, Japan
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School of Radiological Technology, Gunma Prefectural College of Health Sciences, Gunma, Japan
1 Faculty of Informatics, University of Fukuchiyama, Kyoto, Japan
2 Graduate School of Radiological Sciences, International University of Health and Welfare, Tochigi, Japan
3 School of Health Sciences, Fukushima Medical University, Fukushima, Japan
4 School of Radiological Technology, Gunma Prefectural College of Health Sciences, Gunma, Japan
Cross entropy is a measure in machine learning and deep learning that assesses the difference between predicted and actual probability distributions. In this study, we propose cross entropy as a performance evaluation metric for image classifier models and apply it to the CT image classification of lung cancer. A convolutional neural network is employed as the deep neural network (DNN) image classifier, with the residual network (ResNet) 50 chosen as the DNN archi-tecture. The image data used comprise a lung CT image set. Two classification models are built from datasets with varying amounts of data, and lung cancer is categorized into four classes using 10-fold cross-validation. Furthermore, we employ t-distributed stochastic neighbor embedding to visually explain the data distribution after classification. Experimental results demonstrate that cross en-tropy is a highly useful metric for evaluating the reliability of image classifier models. It is noted that for a more comprehensive evaluation of model perfor-mance, combining with other evaluation metrics is considered essential.
Siegel, R.L., Miller, K.D., Wagle, N.S. and Jemal, A. (2023) Cancer Statistics, 2023. CA: A Cancer Journal for Clinicians, 73, 17-48. https://doi.org/10.3322/caac.21763
Xu, R., Lu, T., Wang, C., Li, Q., Peng, B., Zhao, J., et al. (2023) Single-Cell Data Analysis of Malignant Epithelial Cell Heterogeneity in Lung Adenocarcinoma for Patient Classification and Prognosis Prediction. Heliyon, 9, e20164. https://doi.org/10.1016/j.heliyon.2023.e20164
Niu, Z., Jin, R., Zhang, Y. and Li, H. (2022) Signaling Pathways and Targeted Therapies in Lung Squamous Cell Carcinoma: Mechanisms and Clinical Trials. Signal Transduction and Targeted Therapy, 7, 353. https://doi.org/10.1038/s41392-022-01200-x
Copin, M.-C. (2016) Carcinome à Grandes Cellules, Carcinome Lymphoepithelioma-Like, Carcinome NUT Large Cell Carcinoma, Lymphoepithelioma-Like Carcinoma, NUT Carcinoma. Annales de Pathologie, 36, 24-33. https://doi.org/10.1016/j.annpat.2015.11.006
The National Lung Screening Trial Research Team (2011) Reduced Lung-Cancer Mortality with Low-Dose Computed Tomographic Screening. The New England Journal of Medicine, 365, 395-409. https://doi.org/10.1056/NEJMoa1102873
Aberle, D.R., DeMello, S., Berg, C.D., Black, W.C., Brewer, B., Church, T.R., et al. (2013) Results of the Two Incidence Screenings in the National Lung Screening Trial. The New England Journal of Medicine, 369, 920-931. https://doi.org/10.1056/NEJMoa1208962
The National Lung Screening Trial Research Team (2013) Results of Initial Low-Dose Computed Tomographic Screening for Lung Cancer. The New England Journal of Medicine, 368, 1980-1991. https://doi.org/10.1056/NEJMoa1209120
Kramer, B.S., Berg, C.D., Aberle, D.R. and Prorok, P.C. (2011) Lung Cancer Screening with Low-Dose Helical CT: Results from the National Lung Screening Trial (NLST). Journal of Medical Screening, 18, 109-111. https://doi.org/10.1258/jms.2011.011055
Midthun, D.E. (2011) Screening for Lung Cancer. Clinics in Chest Medicine, 32, 659-668. https://doi.org/10.1016/j.ccm.2011.08.014
Goo, J.M. (2011) A Computer-Aided Diagnosis for Evaluating Lung Nodules on Chest CT: The Current Status and Perspective. Korean Journal of Radiology, 12, 145-155. https://doi.org/10.3348/kjr.2011.12.2.145
Suzuki, K. (2012) A Review of Computer-Aided Diagnosis in Thoracic and Colonic Imaging. Quantitative Imaging in Medicine and Surgery, 2, 163-176.
El-Baz, A., Beache, G.M., Gimel’farb, G., Suzuki, K., Okada, K., et al. (2013) Computer-Aided Diagnosis Systems for Lung Cancer: Challenges and Methodologies. International Journal of Biomedical Imaging, 2013, Article ID: 942353. https://doi.org/10.1155/2013/942353
Retico, A. (2013) Computer-Aided Detection for Pulmonary Nodule Identification: Improving the Radiologist’s Performance? Imaging in Medicine, 5, 249-263. https://doi.org/10.2217/iim.13.24
Firmino, M., Morais, A.H., Mendoca, R.M., Dantas, M.R., Hekis, H.R. and Valentim, R. (2014) Computer-Aided Detection System for Lung Cancer in Computed Tomography Scans: Review and Future Prospective. Biomedical Engineering Online, 13, 1-16. https://doi.org/10.1186/1475-925X-13-41
Vaswani, A., Shazeer, N., Parmar, N., Uszkoreit, J., Jones, L., Gomez, A.N., et al. (2017) Attention Is All You Need.
Dosovitskiy, A., Beyer, L., Kolesnikov, A., Weissenborn, D., Zhai, X., Unterthiner, T., et al. (2020) An Image Is Worth 16x16 Words: Transformers for Image Recognition at Scale.
Anthimopoulos, M., Christodoulidis, S., Ebner, L., Christe, A. and Mougiakakou, S. (2016) Lung Pattern Classification for Interstitial Lung Diseases Using a Deep Convolutional Neural Network. IEEE Transactions on Medical Imaging, 35, 1207-1216. https://doi.org/10.1109/TMI.2016.2535865
Gao, M., Bagci, U., Lu, L., Wu, A., Buty, M., Shin, H.C., et al. (2018) Holistic Classification of CT Attenuation Patterns for Interstitial Lung Diseases via Deep Convolutional Neural Networks. Computer Methods in Biomechanics and Biomedical Engineering: Imaging & Visualization, 6, 1-6. https://doi.org/10.1080/21681163.2015.1124249
Matsuyama, E., Lee, Y., Takahashi, N. and Tsai, D.Y. (2019)A Wavelet Coefficient-Based Convolutional Neural Network for Histological Classification of Lung Cancer in CT Images. Japanese Journal of Imaging and Information Sciences in Medicine (In Japanese), 36, 64-71.
Zech, J.R., Badgeley, M.A., Liu, M., Costa, A.B., Titano, J. and Oermann, E.K. (2018) Variable Generalization Performance of a Deep Learning Model to Detect Pneumonia in Chest Radiographs: A Cross-Sectional Study. PLOS Medicine, 15, e1002683. https://doi.org/10.1371/journal.pmed.1002683
Ovadia, Y., Fertig, E., Ren, J., Nado. Z., Sculley, D., Nowozin, S., et al. (2019) Can You Trust Your Model’s Uncertainty? Evaluating Predictive Uncertainty under Dataset Shift. 33rd International Conference on Neural Information Processing Systems, Vancouver, 8-14 December 2019, 13969-13980.
Guo, C., Pleiss, G., Sun Y. and Weinberger, K.Q. (2017)On Calibration of Modern Neural Networks. Proceedings of the 34th International Conference on Machine Learning, Sydney, Vol. 70, 1321-1330. https://proceedings.mlr.press/v70/guo17a.html
Gal, Y. and Ghahramani, Z. (2016) Dropout as a Bayesian Approximation: Representing Model Uncertainty in Deep Learning. Proceedings of the 33rd International Conference on Machine Learning, Vol. 48, 1050-1059.
He, K., Zhang, X., Ren, S. and Sun, J. (2015) Deep Residual Learning for Image Recognition. 2016 IEEE Conference on Computer Vision and Pattern Recognition (CVPR), Las Vegas, 27-30 June 2016, 770-778. https://doi.org/10.1109/CVPR.2016.90
Narayanan, B.N., De Silva, M.S., Hardie, R.C., Kueterman, N.K. and Ali, R. (2019) Understanding Deep Neural Network Predictions for Medical Imaging Applications.
van der Maaten, L.J.P. and Hinton, G.E. (2008) Visualizing High-Dimensional Data Using t-SNE. Journal of Machine Learning Research, 9, 2579-2605.
Shan, B. and Fang, Y. (2020) A Cross Entropy Based Deep Neural Network Model for Road Extraction from Satellite Images. Entropy, 22, Article No. 535. https://doi.org/10.3390/e22050535
Kurian, N.C., Meshram, P.S., Patil, A., Patel S. and Sethi, A. (2021) Sample Specific Generalized Cross Entropy for Robust Histology Image Classification. 2021 IEEE 18th International Symposium on Biomedical Imaging (ISBI), Nice, 13-16 April 2021, 1934-1938. https://doi.org/10.1109/ISBI48211.2021.9434169
Mannor, S., Peleg, D. and Rubinstein, R. (2005) The Cross Entropy Method for Classification. Proceedings of the 22nd International Conference on Machine Learning, Bonn, 7-11 August 2005, 561-568. https://doi.org/10.1145/1102351.1102422
Brownlee, J. (2020) A Gentle Introduction to Cross-Entropy for Machine Learning. https://machinelearningmastery.com/cross-entropy-for-machine-learning/
Mao, A., Mohri, M. and Zhong, Y. (2023) Cross-Entropy Loss Functions: Theoretical Analysis and Applications. Proceedings of the 40th International Conference on Machine Learning, Honolulu, Vol. 202, 23803-23828. https://proceedings.mlr.press/v202/mao23b/mao23b.pdf
Nova (2023) A Comprehensive Guide to Cross Entropy in Machine Learning. https://aitechtrend.com/a-comprehensive-guide-to-cross-entropy-in-machine-learning/
Sheikh, I. (2023) Understanding Cross-Entropy Loss and Its Role in Classification Problems. https://medium.com/@l228104/understanding-cross-entropy-loss-and-its-role-in-classification-problems-d2550f2caad5