Tamanu oil, derived from the nuts of Calophyllum inophyllum , has gained increasing attention for its potential in acne management due to its purported anti-inflammatory and wound-healing properties. This analysis evaluates the efficacy of tamanu oil in acne treatment with a specific focus on its impact on inflammation and scar reduction. The novelty of this research lies in its comprehensive analysis of tamanu oil’s dual mechanism of action: reducing acne-related inflammation and promoting the healing of acne scars. Clinical trials and laboratory analyses were conducted to assess the oil’s effectiveness in diminishing erythema, swelling, and post-acne scarring compared to conventional treatments. Preliminary findings demonstrate that tamanu oil significantly reduces inflammation and accelerates wound healing, potentially offering a promising adjunct or alternative to standard acne therapies. Future research should aim to optimize formulation and application protocols, long-term effects, and comparative therapeutic efficacy with other anti-inflammatory agents. Tamanu oil offers a novel and effective approach to acne management, with potential advantages that go beyond inflammation reduction to include enhanced scar reduction, making it a subject that warrants further investigation.
Oge’, L.K., Broussard, A. and Marshall, M.D. (2019) Acne Vulgaris: Diagnosis and Treatment. American Family Physician , 100, 475-484.
Sutaria, A.H., Masood, S., Saleh, H.M. and Schlessinger, J. (2024) Acne Vulgaris. StatPearls Publishing. http://www.ncbi.nlm.nih.gov/books/NBK459173/
Pribowo, A., Girish, J., Gustiananda, M., Nandhira, R.G. and Hartrianti, P. (2021) Potential of Tamanu ( Calophyllum inophyllum ) Oil for Atopic Dermatitis Treatment. Evidence - Based Complementary and Alternative Medicine , 2021, Article ID: 6332867. https://doi.org/10.1155/2021/6332867
Poljšak, N., Kreft, S. and Kočevar Glavač, N. (2019) Vegetable Butters and Oils in Skin Wound Healing: Scientific Evidence for New Opportunities in Dermatology. Phytotherapy Research , 34, 254-269. https://doi.org/10.1002/ptr.6524
Nguyen, V., Truong, C., Nguyen, B.C.Q., Vo, T.V., Dao, T., Nguyen, V., et al . (2017) Anti-Inflammatory and Wound Healing Activities of Calophyllolide Isolated from Calophyllum inophyllum Linn. PLOS ONE , 12, e0185674. https://doi.org/10.1371/journal.pone.0185674
Léguillier, T., Lecsö-Bornet, M., Lémus, C., Rousseau-Ralliard, D., Lebouvier, N., Hnawia, E., et al . (2015) The Wound Healing and Antibacterial Activity of Five Ethnomedical Calophyllum inophyllum Oils: An Alternative Therapeutic Strategy to Treat Infected Wounds. PLOS ONE , 10, e0138602. https://doi.org/10.1371/journal.pone.0138602
Cassien, M., Mercier, A., Thétiot-Laurent, S., Culcasi, M., Ricquebourg, E., Asteian, A., et al . (2021) Improving the Antioxidant Properties of Calophyllum inophyllum Seed Oil from French Polynesia: Development and Biological Applications of Resinous Ethanol-Soluble Extracts. Antioxidants , 10, Article No. 199. https://doi.org/10.3390/antiox10020199
Saxena, R., Nath, R., Palit, G., Nigam, S. and Bhargava, K. (1982) Effect of Calophyllolide, a Nonsteroidal Anti-Inflammatory Agent, on Capillary Permeability. Planta Medica , 44, 246-248. https://doi.org/10.1055/s-2007-971459
Ghashghaii, A., Hashemnia, M., Nikousefat, Z., Zangeneh, M.M. and Zangeneh, A. (2017) Wound Healing Potential of Methanolic Extract of Scrophularia Striata in Rats. Pharmaceutical Sciences , 23, 256-263. https://doi.org/10.15171/ps.2017.38
Erdogan, S.S., Gur, T.F., Terzi, N.K. and Dogan, B. (2021) Evaluation of the Cutaneous Wound Healing Potential of Tamanu Oil in Wounds Induced in Rats. Journal of Wound Care , 30, Vi-Vx. https://doi.org/10.12968/jowc.2021.30.sup9a.v
Dweck, A.C. and Meadows, T. (2002) Tamanu ( Calophyllum inophyllum )—The African, Asian, Polynesian and Pacific Panacea. International Journal of Cosmetic Science , 24, 341-348. https://doi.org/10.1046/j.1467-2494.2002.00160.x
Krishnappa, M., Abraham, S., Furtado, S.C., Krishnamurthy, S., Rifaya, A., Asiri, Y.I., et al . (2024) An Integrated Computational and Experimental Approach to Formulate Tamanu Oil Bigels as Anti-Scarring Agent. Pharmaceuticals , 17, Article No. 102. https://doi.org/10.3390/ph17010102
Ansel, J., Lupo, E., Mijouin, L., Guillot, S., Butaud, J., Ho, R., et al . (2016) Biological Activity of Polynesian Calophyllum inophyllum Oil Extract on Human Skin Cells. Planta Medica , 82, 961-966. https://doi.org/10.1055/s-0042-108205
Cruz, S., Vecerek, N. and Elbuluk, N. (2023) Targeting Inflammation in Acne: Current Treatments and Future Prospects. American Journal of Clinical Dermatology , 24, 681-694. https://doi.org/10.1007/s40257-023-00789-1
Fabbrocini, G., Annunziata, M.C., D’Arco, V., De Vita, V., Lodi, G., Mauriello, M.C., et al . (2010) Acne Scars: Pathogenesis, Classification and Treatment. Dermatology Research and Practice , 2010, Article ID: 893080. https://doi.org/10.1155/2010/893080
Raharivelomanana, P., Ansel, J., Lupo, E., Mijouin, L., Guillot, S., Butaud, J., et al . (2018) Tamanu Oil and Skin Active Properties: From Traditional to Modern Cosmetic Uses. OCL , 25, D504. https://doi.org/10.1051/ocl/2018048
McCusker, M.M. and Grant-Kels, J.M. (2010) Healing Fats of the Skin: The Structural and Immunologic Roles of the Ω-6 and Ω-3 Fatty Acids. Clinics in Dermatology , 28, 440-451. https://doi.org/10.1016/j.clindermatol.2010.03.020
Ruangsuriya, J., Sichaem, J., Tantraworasin, A., Saeteng, S., Wongmaneerung, P., Inta, A., et al . (2023) Phytochemical Profiles and Anticancer Effects of Calophyllum inophyllum L. Extract Relating to Reactive Oxygen Species Modulation on Patient-Derived Cells from Breast and Lung Cancers. Scientifica , 2023, Article ID: 6613670. https://doi.org/10.1155/2023/6613670
Addor, F.A.S. (2017) Antioxidants in Dermatology. Anais Brasileiros de Dermatologia , 92, 356-362. https://doi.org/10.1590/abd1806-4841.20175697
Čižmárová, B., Hubková, B., Tomečková, V. and Birková, A. (2023) Flavonoids as Promising Natural Compounds in the Prevention and Treatment of Selected Skin Diseases. International Journal of Molecular Sciences , 24, Article No. 6324. https://doi.org/10.3390/ijms24076324
Zalewski, J., Mączyńska, J., Bieżuńska-Kusiak, K., Kulbacka, J., Choromańska, A., Przestrzelska, M., et al . (2019) Calophyllum inophyllum in Vaginitis Treatment: Stimulated by Electroporation with an in Vitro Approach. Advances in Clinical and Experimental Medicine , 28, 223-228. https://doi.org/10.17219/acem/87045
Valerón-Almazán, P., Gómez-Duaso, A.J., Santana-Molina, N., García-Bello, M.A. and Carretero, G. (2015) Evolution of Post-Surgical Scars Treated with Pure Rosehip Seed Oil. Journal of Cosmetics , Dermatological Sciences and Applications , 5, 161-167. https://doi.org/10.4236/jcdsa.2015.52019
Vasam, M., Korutla, S. and Bohara, R.A. (2023) Acne Vulgaris: A Review of the Pathophysiology, Treatment, and Recent Nanotechnology Based Advances. Biochemistry and Biophysics Reports , 36, Article ID: 101578. https://doi.org/10.1016/j.bbrep.2023.101578
Le Coz, C. (2004) Allergic Contact Dermatitis from Tamanu Oil ( Calophyllum inophyllum , Calophyllum tacamahaca ). Contact Dermatitis , 51, 216-217. https://doi.org/10.1111/j.0105-1873.2004.0424h.x
Ma, N., Liu, X., Yang, Y., Li, J., Mohamed, I., Liu, G., et al . (2015) Preventive Effect of Aspirin Eugenol Ester on Thrombosis in Κ-Carrageenan-Induced Rat Tail Thrombosis Model. PLOS ONE , 10, e0133125. https://doi.org/10.1371/journal.pone.0133125
Zia, K. (2014) Emotional State and Psychological Well-Being of Dermatological Patients. Open Access Library Journal , 1, e434. https://doi.org/10.4236/oalib.1100434
Ginigini, J., Lecellier, G.J., Nicolas, M., Nour, M., Hnawia, E., Lebouvier, N., et al . (2019) Chemodiversity of Calophyllum inophyllum L. Oil Bioactive Components Related to Their Specific Geographical Distribution in the South Pacific Region. PeerJ , 7, e6896. https://doi.org/10.7717/peerj.6896
Nurzyńska-Wierdak, R., Pietrasik, D. and Walasek-Janusz, M. (2022) Essential Oils in the Treatment of Various Types of Acne—A Review. Plants , 12, Article No. 90. https://doi.org/10.3390/plants12010090