Amniotic membrane as a potent source of stem cells and a matrix for engineering heart tissue — Oak Academic Publishing
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Amniotic membrane as a potent source of stem cells and a matrix for engineering heart tissue
Bioprocess Engineering and Biotechnology Department, Federal University of Paraná, Curitiba, Brazil 2Cell Therapy and Biotechnology in Regenerative Medicine Research Group, Pelé Pequeno Príncipe Institute, Curitiba, Brazil
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Cell Therapy and Biotechnology in Regenerative Medicine Research Group, Pelé Pequeno Príncipe Institute, Curitiba, Brazil
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Experimental Laboratory of Institute of Biological and Health Sciences, Pontificial Catholic University of Paraná (PUCPR), Rua Imaculada Concei??o, Curitiba, Brazil
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Experimental Laboratory of Institute of Biological and Health Sciences, Pontificial Catholic University of Paraná (PUCPR), Rua Imaculada Concei??o, Curitiba, Brazil
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Bioprocess Engineering and Biotechnology Department, Federal University of Paraná, Curitiba, BrazilFederal University of Technology, Curitiba, Brazil
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Cell Therapy and Biotechnology in Regenerative Medicine Research Group, Pelé Pequeno Príncipe Institute, Curitiba, Brazil
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Cell Therapy and Biotechnology in Regenerative Medicine Research Group, Pelé Pequeno Príncipe Institute, Curitiba, Brazil
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Department of Hematology, Stem Cell Research Faculty, Sanjay Gandhi Post-Graduate Institute of Medical Sciences, Lucknow, India
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Department of Hematology, Stem Cell Research Faculty, Sanjay Gandhi Post-Graduate Institute of Medical Sciences, Lucknow, India
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Laboratory of Biosurgical Research, Pompidou Hospital, University of Paris Descartes, Paris, France
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1Bioprocess Engineering and Biotechnology Department, Federal University of Paraná, Curitiba, Brazil 2Cell Therapy and Biotechnology in Regenerative Medicine Research Group, Pelé Pequeno Príncipe Institute, Curitiba, Brazil
1 Bioprocess Engineering and Biotechnology Department, Federal University of Paraná, Curitiba, Brazil 2Cell Therapy and Biotechnology in Regenerative Medicine Research Group, Pelé Pequeno Príncipe Institute, Curitiba, Brazil
2 Cell Therapy and Biotechnology in Regenerative Medicine Research Group, Pelé Pequeno Príncipe Institute, Curitiba, Brazil
3 Experimental Laboratory of Institute of Biological and Health Sciences, Pontificial Catholic University of Paraná (PUCPR), Rua Imaculada Concei??o, Curitiba, Brazil
4 Experimental Laboratory of Institute of Biological and Health Sciences, Pontificial Catholic University of Paraná (PUCPR), Rua Imaculada Concei??o, Curitiba, Brazil
5 Bioprocess Engineering and Biotechnology Department, Federal University of Paraná, Curitiba, BrazilFederal University of Technology, Curitiba, Brazil
6 Cell Therapy and Biotechnology in Regenerative Medicine Research Group, Pelé Pequeno Príncipe Institute, Curitiba, Brazil
7 Cell Therapy and Biotechnology in Regenerative Medicine Research Group, Pelé Pequeno Príncipe Institute, Curitiba, Brazil
8 Department of Hematology, Stem Cell Research Faculty, Sanjay Gandhi Post-Graduate Institute of Medical Sciences, Lucknow, India
9 Department of Hematology, Stem Cell Research Faculty, Sanjay Gandhi Post-Graduate Institute of Medical Sciences, Lucknow, India
10 Laboratory of Biosurgical Research, Pompidou Hospital, University of Paris Descartes, Paris, France
11 1Bioprocess Engineering and Biotechnology Department, Federal University of Paraná, Curitiba, Brazil 2Cell Therapy and Biotechnology in Regenerative Medicine Research Group, Pelé Pequeno Príncipe Institute, Curitiba, Brazil
Existing therapies for the treatment of chronic heart failure still have some limitations and there is a pressing need for the development of new therapeutic modalities. The amniotic membrane has been used for the treatment of various diseases, such as conjunctive defects; however, the mechanisms behind its repair functions are still unclear. Regenerative medicine is seeking newer alternatives and among them, biomaterials have emerged in recent years for developing and manipulating molecules, cells, tissues or organs grown in laboratories in order to replace human body parts. Many such materials have been used for this purpose, either synthetically or biologically, in order to provide new medical devices. This review provides a wider view of the regeneration potential of the use of amniotic membrane as a potential biomaterial to facilitate the implementation of new research in surgical procedures. Amniotic membrane appears to be an alternative source of stem cells as well as an excellent biomaterial for cell-based therapeutic applications in engineering heart tissue.
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