The novel quaternary ammonium bromide (QAB)-containing oligomers were synthesized and applied for developing an antibacterial resin composite. Compressive strength (CS) and S. mutans (an oral bacteria strain) viability were used to evaluate the mechanical strength and antibacterial activity of the formed composites. All the QAB-modified resin composites showed significant antibacterial activity and mechanical strength reduction. Increasing chain length and loading significantly enhanced the antibacterial activity but dramatically reduced the CS as well. The 30-day aging study showed that the incorporation of the QAB accelerated the degradation of the composite, suggesting that the QAB may not be well suitable for development of antibacterial dental resin composites or at least the QAB loading should be well controlled, unlike its use in dental glass-ionomer cements. The work in this study is beneficial and valuable to those who are interested in studying antibacterial dental resin composites.
Mjor, I.A., Dahl, J.E. and Moorhead, J.E. (2002) Place- ment and replacement of restorations in primary teeth. Acta Odontologica Scandinavica, 60, 25-28. doi:10.1080/000163502753471961
Forss, H. and Widstrom, E. (2004) Reasons for restora- tive therapy and longevity of restorations in adults. Acta Odontologica Scandinavica, 62, 82-86. doi:10.1080/00016350310008733
Manhart, J., Godoy, F.G. and Hickel, R. (2002) Direct posterior restorations: clinical results and new develop- ments. Dental Clinics of North America, 46, 303-339. doi:10.1016/S0011-8532(01)00010-6
Deligeorgi, V., Mjor, I.A. and Wilson, N.H. (2001) An overview of reasons for the placement and replacement of restorations. Primary Dental Care: Journal of the Fac- ulty of General Dental Practitioners, 8, 5-11.
Wiegand, A., Buchalla, W. and Attin, T. (2007) Review on fluoride-releasing restorative materials—Fluoride re- lease and uptake characteristics, antibacterial activity and influence on caries formation. Dental Materials, 23, 343-362. doi:10.1016/j.dental.2006.01.022
Osinaga, P.W., Grande, R.H., Ballester, R.Y., Simionato, M. R., Rodrigues, C. R. D. and Muench, A. (2003) Zinc sulfate addition to glass-ionomer-based cements: Influ- ence on physical and antibacterial properties, zinc and fluoride release. Dental Materials, 19, 212-217. doi:10.1016/S0109-5641(02)00032-5
Takahashi, Y., Imazato, S., Kaneshiro, A. V., Ebisu, S., Frencken, J. E. and Tay, F. R. (2006) Antibacterial effects and physical properties of glass-ionomer cements con- taining chlorhexidine for the ART approach. Dental Ma- terials, 22, 647-652.
Yamamoto, K., Ohashi, S., Aono, M., Kokybu, T., Yamada, I. and Yamauchi, J. (1996) Antibacterial activity of silver ions implanted in SiO2 filler on oral streptococci. Dental Materials, 12, 227-229. doi:10.1016/S0109-5641(96)80027-3
Syafiuddin, T., Hisamitsu, H., Toko, T., Igarashi, T., Goto, N., Fujishima, A. and Miyazaki, T. (1997) In vitro inhibi- tion of caries around a resin composite restoration con- taining antibacterial filler. Biomaterials, 18, 1051- 1057. doi:10.1016/S0142-9612(97)88072-6
Gottenbos, B., Mei, H. C., Klatter, F., Nieuwenhuis, P. and Busscher, H. J. (2002) In vitro and in vivo antimicro- bial activity of covalently coupled quaternary ammonium silane coatings on silicone rubber. Biomaterials, 23, 1417-1423. doi:10.1016/S0142-9612(01)00263-0
Thebault, P., Givenchy, E. T., Levy, R., Vandenberghe, Y., Guittard, F. and Geribaldi, S. (2009) Preparation and an- timicrobial behavior of quaternary ammonium thiol de- rivatives able to be grafted on metal surfaces. European Journal of Medicinal Chemistry, 44, 717-724. doi:10.1016/j.ejmech.2008.05.007
Imazato, S., Russell, R. R. and McCabe, J. F. (1995) An- tibacterial activity of MDPB polymer incorporated in dental resin. Journal of Dentistry, 23, 177-181. doi:10.1016/0300-5712(95)93576-N
Murata, H., Koepsel, R. R., Matyjaszewski, K. and Rus- sell, A. J., (2007) Permanent, non-leaching antibacterial surfaces—2: How high density cationic surfaces kill bacte- rial cells. Biomaterials, 28, 4870-4879. doi:10.1016/j.biomaterials.2007.06.012
Lu, G., Wu, D. and Fu, R. (2007) Studies on the synthesis and antibacterial activities of polymeric quaternary am- monium salts from dimethylaminoethyl methacrylate. Reactive and Functional Polymers, 67, 355-366. doi:10.1016/j.reactfunctpolym.2007.01.008
Lee, S. B., Koepsel, R. R., Morley, S. W., Matyjaszewski, K., Sun, Y. and Russell, A. J. (2004) Permanent, nonleach- ing antibacterial surfaces. 1. Synthesis by atom transfer radical polymerization. Biomacromolecules, 5, 877-882. doi:10.1021/bm034352k
Li, F., Chai, Z. G., Sun, M. N., Wang, F., Ma, S., Zhang, L., Fang, M. and Chen, J. H. (2009) Anti-biofilm effect of dental adhesive with cationic monomer. Journal of Dental Research, 88, 372-376. doi:10.1177/0022034509334499
Li, F., Chen, J., Chai, Z., Zhang, L., Xiao, Y., Fang, M. and Ma, S. (2009) Effects of a dental adhesive incorporating antibacterial monomer on the growth, adherence and membrane integrity of Streptococcus mutans. Journal of Dentistry, 37, 289-296. doi:10.1016/j.jdent.2008.12.004
Beyth, N., Farber, I. Y. Y., Bahir, R., Domb, A. J. and Weiss, E. I. (2006) Antibacterial activity of dental com- posites containing quaternary ammonium polyethylene- imine nanoparticles against Streptococcus mutans. Bio- materials, 27, 3995-4002. doi:10.1016/j.biomaterials.2006.03.003
Beyth, N., Yudovin-Farberb, I., Perez-Davidia, M., Domb, A. J. and Weiss, E. I. (2010) Polyethyleneimine nanopar- ticles incorporated into resin composite cause cell death and trigger biofilm stress in vivo. Proceedings of the National Academy of Science, 107, 22038-22043. doi:10.1073/pnas.1010341107
Xie, D., Chung, I-D., Wang, G. and Mays, J. (2006) Syn- thesis and evaluation of novel bifunctional oligomerbased composites for dental applications. Journal of Biomate- rials Applications, 20, 221-236.
Xie, D., Chung, I-D., Wang, G., Feng, D. and Mays, J. (2004) Synthesis, formulation and evaluation of novel zinc-calcium phosphate-based adhesive resin composite cement. European Polymer Journal, 40, 1723-1731. doi:10.1016/j.eurpolymj.2004.03.005
Wei, G. X., Campagna, A. N. and Bobek, L. A. (2007) Factors affecting antimicrobial activity of muc7 12-mer, a human salivary mucin-derived peptide. Annals of Clini- cal Microbiology and Antimicrobials, 6, 1-10.
Kim, Y., Farrah, S. and Baney R.H. (2007) Membrane damage of bacteria by silanols treatment. Electronic Journal of Biotechnology, 10, 252-259. doi:10.2225/vol10-issue2-fulltext-7
Shackelford, J. F. (2009) Introduction to Materials Sci- ence for Engineers. 7th Edition, Pearson Education, Inc., Upper Saddle River.
Wang, G., Weng, Y., Chu, D., Xie, D. and Chen, R. (2009) Preparation of alkaline anion exchange membranes based on functional poly(ether-imide) polymers for potential fuel cell applications. Journal of Membrane Science, 326, 4-8. doi:10.1016/j.memsci.2008.09.037
Dermaut, W., van den Kerkhof, T., van der Veken, B. J., Mertens, R. and Geise, H. J. (2000) Cold stretching of PPV with water as a plasticizer. Macromolecules, 33, 5634-5637. doi:10.1021/ma992062j
Lio, K., Minoura, N. and Nagura, M. (1995) Swelling characteristics of a blend hydrogel made of poly (allyl- biguanido-co-allylamine) and poly(vinyl alcohol). Poly- mer, 36 (13), 2579-2583. doi:10.1016/0032-3861(95)91204-K
Drummond, J. L. (2008) Degradation, Fatigue, and Fail- ure of Resin Dental Composite Materials. Journal of Den- tal Research, 87, 710-719. doi:10.1177/154405910808700802
Weng, Y., Guo, X., Gregory, R. L. and Xie, D. (2010). A novel antibacterial glass-ionomer cement. European Jour- nal of Oral Science, 118, 531-534.