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Arava Treatment, between Beneficial Action on Joint Inflammation and Side Effects on Liver, Myocardium and Kidney in Experimental Murine Arthritis
Pathophysiology Department, University of Medicine and Pharmacy “Grigore T. Popa”, Iasi, Romania
Internal Medicine Clinic, St. Spiridon Hospital, Iasi, Romania
Pathophysiology Department, University of Medicine and Pharmacy “Grigore T. Popa”, Iasi, Romania
Pathophysiology Department, University of Medicine and Pharmacy “Grigore T. Popa”, Iasi, Romania
Pathophysiology Department, University of Medicine and Pharmacy “Grigore T. Popa”, Iasi, Romania
- 1 Pathophysiology Department, University of Medicine and Pharmacy “Grigore T. Popa”, Iasi, Romania
- 2 Internal Medicine Clinic, St. Spiridon Hospital, Iasi, Romania
- 3 Pathophysiology Department, University of Medicine and Pharmacy “Grigore T. Popa”, Iasi, Romania
- 4 Pathophysiology Department, University of Medicine and Pharmacy “Grigore T. Popa”, Iasi, Romania
- 5 Pathophysiology Department, University of Medicine and Pharmacy “Grigore T. Popa”, Iasi, Romania
Journal of Biomedical Science and Engineering·Volume 07 (2014)·Pages 712–720·Published 4 July 2014·DOI10.4236/jbise.2014.79070
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Abstract
The purpose of the experiment was the follow-up in time of the course of joint inflammation phenomena in laboratory animals (white female adult Wistar rats) by determining particular biological, hematological, radiological, osteodensitometric, immunological and anatomic-pathological parameters and by assessing the effects of Leflunomide (Arava) on the course of the disease. ARAVA<sup>®</sup> (Leflunomide) is a pyrimidine synthesis inhibitor. The experimental study was conducted for 8 weeks. We have also assessed the side effects of the therapy on their liver, myocardium and kidney. Leflunomide therapy improved the course of the clinical and paraclinical parameters, but it did not cure the condition. The positive results in the joints were accompanied by many histological alterations. The experiment revealed the toxic visceral effects of Leflunomide on the liver, heart and kidney.
KeywordsARAVA®(Leflunomide)Rheumatoid ArthritisSide Effects
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