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Exploring diversity of different classificatory human tandem repeats
College of Life Sciences, Sichuan University
College of Life Sciences, Sichuan University
College of Life Sciences, Sichuan University
College of Life Sciences, Sichuan University
College of Life Sciences, Sichuan University
- 1 College of Life Sciences, Sichuan University
- 2 College of Life Sciences, Sichuan University
- 3 College of Life Sciences, Sichuan University
- 4 College of Life Sciences, Sichuan University
- 5 College of Life Sciences, Sichuan University
Journal of Biomedical Science and Engineering·Volume 01 (2008)·Pages 127–132·Published 1 August 2008·DOI10.4236/jbise.2008.12021
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Abstract
Tandem repeats (TRs) are associated with dis-ease genes, play an important role in evolution and are important in genomic organization and function. Much research has been done on de-scriptions of properties of tandem repeats, such as copy-number, period, etc, and correlation be-tween mutations within tandem repeats and dis-ease. This project aims to detect some differ-ences which may exist within the features of dif-ferent tandem repeats associated with disease in human whole-genome. The features of tandem repeats associated with diabetes genes were compared to the counterparts of non-diabetes disease genes.
KeywordsDiversity of different classificatoryHuman tandem repeats
- Buard, J. and Vergnaud, G. (1994) Complex recombination events at the hypermutable minisatellite CEB1 (D2S90). EMBO J. 13, 3203-3210.
- Van Belkum, A., Scherer, S., and Verbrugh, H. (1998) Short-sequences DNA repeats in prokaryotic genomes, Microbiol. Mol.Biol.Rev. 62, 275-293.
- Rubinsztein. D.C., Amos, B, and Cooper, G. (1999) Microsatellite and trinucleotide-repeat evolution: evidence for mutational bias and different rates of evolution in different lineages. Phil. Trans. R. Soc. Lond. B 354, 1095-1099.
- Sutherland, G..R.and Richards, R.I. (1995) Simple tandem DNA repeats and human genetic disease. Proc. Natl. Acad. Sci. USA 92 3636-3641.
- Tóth,G., Gaspari,Z. and Jurka,J. (2000) Microsatellites in different eukaryotic genomes: survey and analysis. Genome Res., 10, 967–981.
- Hancock, J.M., Worthey, E.A. and Santibez-Koref, M.F. (2001) A Role for Selection in Regulating the Evolutionary Emergence of Disease-Causing and Other Coding CAG Repeats in Humans and Mice. Mol. Biol. Evol. 18, 1014-1023.
- Kajava .A.V (2001) Review: Proteins with repeated sequence – structural prediction and modeling. Jour. Stru. Biol. 134, 132-144.
- Huang C., Lin Y., Yang Y., Huang S. and Chen C. (1998). The telomeres of Streptomyces chromosomes contain conserved palin-dromic sequences with potential to form complex secondary struc-tures. Mol. Microbiol. 28, 905–916.
- Richard G. F., Hennequin C., Thierry A. and Dujon B. (1999) Trinucleotide repeats and other microsatellites in yeasts. Res. Mi-crobiol. 150, 589–602.
- Heslop-Harrison J. S. (2003( Tandemly repeated DNA sequences and centromeric chromosomal regions of Arabidopsis species. Chromosome Res. 11, 241–253.
- Lalioti M. D., Scott H. S., Buresi C., Bottani A., Norris M. A., Malafosse A. and Antonarakis S. E. (1997) Dodecamer repeat ex-pansion in cystatin B gene in progressive myoclonus epilepsy. Na-ture 386, 847–852.
- Wren J. D., Forgacs E., Fondon J. W., Pertsemlidis A., Cheng S. Y. and Gallardo T. et al. 2000 Repeat polymorphisms within gene regions: phenotypic and evolutionary implications. Am. J. Hum. Genet. 67, 345–356..
- Boby T.., Patch A.M., Aves S.J. (2005) TRbase: a database relat-ing tandem repeats to disease genes for the human genome. Bioin-formatics, 21(6):811-6.
- Benson,G. (1999) Tandem Repeats Finder: a program to analyze DNA sequences.Nucleic Acids Res., 27, 573–580.