Calcitonin Participant in the Development of Insulin Resistance — Oak Academic Publishing
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Calcitonin Participant in the Development of Insulin Resistance
Federal State-Financed Establishment of Science, State Scientific Center of Russian Federation, Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Russia
1 Federal State-Financed Establishment of Science, State Scientific Center of Russian Federation, Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Russia
The review contains contemporary literature data about calcitonin role in the development of insulin resistance and its potential role in the pathogenesis of carbohydrate metabolism disturbances. Analogues disturbances revealed under diabetes mellitus and under calcitonin treatment are considered. Literature data about hormone diabetogenicity are discussed. The analysis of experimental and literature data testifies that calcitonin under unfavorable conditions (age, obesity, stress) against the background of the decreasing of functional activity of insular apparatus can lead to the development of metabolic syndrome and diabetes mellitus. It is shown that calcium channel blockers inhibit calcitonin effect leads to glucose intolerance and decreases tissue insulin sensitivity. In this connection a question about direct influence on calcium mechanisms of endocrine system as possible method of drug therapy is discussed.
Moisa, S.S. and Nozdrachev, A.D. (2011) Mechanisms of Calcium and Carbohydrate Metabolism Regulation. LAP LAMBERT Academic Publishing GmbH &Co. KG, Saarbrucken.
Butakova (Moisa), S.S. and Nozdrachev, A.D. (2010) Calcitonin—Contra-Insulin Hormone. Advances in Gerontology, 23, 364-370.
Moisa, S.S. (2013) Contra-Insulin Effect of Calcitonin on Glucose Metabolism. Bulletin of Experimental Biology and Medicine, 156, 183-185. https://doi.org/10.1007/s10517-013-2314-y
Drzhevetskaya, I.A. and Mishina, N.F. (1978) Thyrocalcitonin Participant in Stress Development. The Journal of Physiology, 64, 864-868.
Ferrannini, E. and Mari, A. (2004) Beta Cell Function and Its Relation to Insulin Action in Humans: A Critical Appraisal. Diabetologia, 47, 943-956. https://doi.org/10.1007/s00125-004-1381-z
Guigliano, D., Passariello, N., Sgambato, S., Torella, R. and D’Onofrio, F. (1982) Calcitonin Modulation of Insulin and Glucagons secretion in Man. American Journal of Physiol-ogy, 242, E206-E213.
Iorns, A., Tiedge, M. and lenzen, S. (2002) Thyroxine Induces Pancreatic Beta-Cells Apoptosis in Rats. Diabetologia, 45, 851-855. https://doi.org/10.1007/s00125-002-0842-5
Sandomirskaya, L.D., Lotova, V.I., Kokoreva, G.A. and Kurbatova, L.A. (2000) Reaction of Thyroid Gland on Calcitonin Injection. Proceedings V International Association of Morphologists, Morphology, Moscow, 117, 106.
Soonthornpun, S., Setasuban, W., Thamprasit, A., Chayanunnukul, W., Rattarasam, C. and Geater, A. (2003) Novel Insulin Sensitivity Index Derived from Oral Glucose Tolerance Test. The Journal of Clinical Endocrinology & Metabolism, 88, 1019-1023. https://doi.org/10.1210/jc.2002-021127
Cheatham, B. (2000) GLUT and Company: SNAREing Roles in Insulin-Regulated Glucose Uptake. Trends in Endocrinology and Metabolism, 11, 356-361. https://doi.org/10.1016/S1043-2760(00)00308-8
Butakova (Moisa), S.S. and Nozdrachev, A.D. (2009) Effect of Calcium-Regulating Hormones and Calcium Channel Modulators on Glucose Consumption by Muscle and Adipose Tissues in Vivo and in Vitro. Bulletin of Experimental Biology and Medicine, 148, 171-174. https://doi.org/10.1007/s10517-009-0677-x
Butakova (Moisa), S.S. and Nozdrachev, A.D. (2011) Mechanisms of Hyperglycemic Effect of Calcitonin. Bulletin of Experimental Biology and Medicine, 150, 320-323. https://doi.org/10.1007/s10517-011-1132-3
Garel, J.-M., Barlet, J.P. and Kervran, A. (1975) Metabolic Effects of Calcitonin in the Newborn. American Journal of Physiology, 229, 669-675.
Moore, M.C., Lin, D.W. and Colburn, C.A. (1999) Insulin- and Glucagons-Independent Effects of Calcitonin Gene-Related Peptide in the Conscious Dog. Metabolism: Clinical and Experimental, 48, 603-610. https://doi.org/10.1016/S0026-0495(99)90058-6
Cahova, M., Vavrinkova, H. and Kazdova, L. (2007) Glucose-Fatty Acid Interaction in Skeletal Muscle and Adipose Tissue in Insulin Resistance. Physiological Research, 56, 135-140.
Kelley, D.E., Goodpaster, B.H. and Storlien, L. (2002) Muscle Triglyceride and Insulin Resistance. Annual Review of Nutrition, 22, 325-346. https://doi.org/10.1146/annurev.nutr.22.010402.102912
Vel’kov, V.V. (2008) Free Fatty Acids-A New Marker of Insulin Resistance and Ischemia. Far-East Medical Journal, 4, 120-122.
Zhao, H.-L., Liu, L.-Z., Sui, Y., Ho, S.K.S., Tam, S.-K., Lai, F.M.M., Chan, J.C.N. and Tong, P.C.Y. (2010) Fatty Acids Inhibit Insulin-Mediated Glucose Transport Associated with Actin Remodeling in Rat L6 Muscle Cells. Acta Diabetologica, 47, 331-339. https://doi.org/10.1007/s00592-010-0225-1
Yamaguchi, M., Momose, K. and Takahashi, K. (1985) Stimulatory Effect of Calcitonin on Fatty Acid Synthesis in the Liver of Fed Rats. Hormone and Metabolic Research, 17, 346-350. https://doi.org/10.1055/s-2007-1013539
Passariello, N., Guigliano, D., Sgambato, S., Torella, R. and D’Onofrio, F. (1981) Calcitonin, A Diabetogenic Hormone? The Journal of Clinical Endocrinology and Metabolism, 53, 318-323. https://doi.org/10.1210/jcem-53-2-318
Williams, P.F., Watson, S.K. and Turtle, J.R. (1981) Lanthide Interactions with the Calcium Binding Site of Insulin Receptor. The Endocrine Society of Australia, 24, 50.
Telkova, I.L. (2005) Molecular-Cell Effects of Insulin and Possible Mechanisms of Insulin Resistance Development in Patients with IDC. Advances in Physiology Education, 36, 55-65.
Reaven, G.M. (2004) The Metabolic Syndrome or the Insulin Resistance Syndrome? Different Names, Different Concepts, and Different Goals. Endocrinology and Metabolism Clinics of North America, 33, 283-303. https://doi.org/10.1016/j.ecl.2004.03.002
Kononenko, I.V., Prokof’ev, S.A. and Smirnova, O.M. (2004) Functional State of ?-Cell, Immunological and Clinic-Biochemical Characteristics in the Patients with Low-Progressive Autoimmune Diabetes Adult. Pediatric Endocrinology Reviews, 50, 18-22.
Isomaa, B., Henricsson, M., Almgren, P., Tuomi, T., Taskinen, M.-R. and Groop, L. (2001) The Metabolic Syndrome Influences the Risk of Chronic Complications in Patients with Type II Diabetes. Diabetologia, 44, 1148-1154. https://doi.org/10.1007/s001250100615
Temelkova, S. (2002) Osteoporosis, Induced by Glucocorticoids-a New Problem of the Present Time. Endocrinologia, 7, 24-54.
Mc Dermott, M.T., Kidd, G.S., Blue, P., Ghaed, V. and Hofeldt, F.D. (1983) Reduced Bone Content in Totally Thyroidectomized Patients: Possible Effect of Calcitonin Deficiency. Journal of Clinical Endocrinology and Metabolism, 56, 936-939. https://doi.org/10.1210/jcem-56-5-936
Gattereau, A., Bielmann, P. and Durivage, J. (1977) Hyperglycaemic Effect of Synthetic Salmon Calcitonin. Lancet, 2, 1076-1077. https://doi.org/10.1016/S0140-6736(77)91908-0
Freed, W.J., Perlow, M.J. and Wyatt, R.J. (1979) Calcitonin: Inhibitory Effect on Eating in Rats. Science, 206, 850-852. https://doi.org/10.1126/science.493987
Ziegler, R. (1983) Calcitonin and the Endocrine Pancreas. Triangle, 22, 135-145.
Moisa, S.S. and Nozdrachev, A.D. (2013) One-Time Injection of Calcitonin Induces Glucose Intolerance in Children with the 1st Degree Obesity. Health, 5, 9-13. https://doi.org/10.4236/health.2013.56A1002
Tomic, M., Poljicanin, T., Pavlic-Renar, I. and Meelko, Z. (2003) Obesity-A Risk Factor for Microvascular and Neuropathic Complications in Diabetes? Diabetologia Croatica, 32, 73-78.
Dianov, O.A., Gnusaev, S.F., Yakovlev, B.N. and Gorshkova, M.I. (2008) Neuro-Circular Non-Stability and Metabolic Disorders in Children with Obesity and Its Correction. Vestnik of Pediatric Pharmacology and Nutrimnology, 5, 34-38.
Zhu, J.-F., Liang, L., Wang, C.-L. and Zhou, C.-C. (2006) Dissemination of Complications in Teenagers with Moderate and Hard Obesity. Journal of Applied Clinical Pediatrics, 21, 1320-1321.
Zhang, X., Yu, C. and Li, S. (2003) Insulin and C-Peptide Level in Blood Serum Children with Simple Obesity. Journal of Applied Clinical Pediatrics, 18, 28-29.
Liu, R.H., Mizuta, M., Kurose, T. and Matsukura, S. (2002) Early Events Involved in the Development of Insulin Resistance in Zuker Fatty Rats. International Journal of Obesity, 26, 318-326. https://doi.org/10.1038/sj.ijo.0801924
Kravets, E.B. (1983) Insulin System State under Obesity in Children. In: Kravets, E.B., Ed., Biochemical Identification of Pathological Processes in Clinic and Experiment, Medicine, Moscow, 21-24.
Butakova, S.S. and Nozdrachev, A.D. (2010) Effect of Calcitonin on the Type of Alimentary Hyperglycemia in Rats of Different Age and Sex. Advances in Gerontology, 23, 213-220.
Fink, R.I., Kolterman, O.G., Kao, M. and Olefsky, J.M. (1984) The Role of the Glucose Transport System in the Postreceptor Defect in Insulin Action Associated with Human Aging. The Journal of Clinical Endocrinology and Metabolism, 58, 721-725. https://doi.org/10.1210/jcem-58-4-721
Asghar, Z., Yau, D., Chan, F., Le Roith, D., Chan, C.B. and Wheeler, M.B. (2006) Insulin Resistance Causes Increased Beta-Cells Mass but Defective Glucose-Stimulated Insulin Secretion in a Murine Model of Type 2 Diabetes. Diabetologia, 49, 90-99. https://doi.org/10.1007/s00125-005-0045-y
Rustenbeck, I. (2002) Desentization of Insulin Secretion. Biochemical Pharmacology, 63, 1921-1935. https://doi.org/10.1016/S0006-2952(02)00996-6
Baranov, V.G. and Yaroshevskii, Yu.A. (1980) About Relative Insulin Deficiency as a Primary Factor of Spontaneous Diabetes Mellitus Pathogenesis. Pediatric Endocrinology Reviews, 26, 3-7.
Lasyi, V.P. (2004) Clinic-Instrumental and Laboratory Criterions of the Assessment of the Peculiarities of Tissue Metabolism under Acid-Dependent Diseases of Digestion Organs. Ph.D. Dissertation, Russian Military-Medical Academy, St-Petersburg.
Mosin, V.I., Yagoda, A.V. and Grossman, B.E. (1980) Parathormone, Calcitonin and Cyclic Adenosine-Mono-Phosphate Content in Blood under Diabetes Mellitus. Therapeutic Archive, 52, 80-83.
Zhukovskii, M.A., Yurkov, A.I. and Babaev, K. (1974) The Peculiarities of the Spectrum of Laktat-Dehydrogenase Isoferments in Children Blood Serum, Suffered from Diabetes Mellitus, Depending on Compensation State. Questions of Maternity and Childhood Guard, 19, 90-96.
Scott, F.W., Trick, K.D., Lee, L.P.K., Hynie, I., Heick, H.M.C. and Nera, E.A. (1984) Serum Enzymes in the BB Rat before and after Onset of the Overt Diabetic Syndrome. Clinical Biochemistry, 17, 270-275. https://doi.org/10.1016/S0009-9120(84)90200-5
Fraze, E., Donner, C.C., Swislocki, A.L.M., Chion, Y.-A.M., Chtm, Y.-D.I. and Reaven, G.M. (1985) Ambient Plasma Free Fatty Acid Concentrations in Noninsulin-Dependent Di-abetes Mellitus Evidence for Insulin Resistance. The Journal of Clinical Endocrinology and Metabolism, 61, 897-811. https://doi.org/10.1210/jcem-61-5-807
Kulikova, L.I., Tsvetkov V.S., Bondarenko, M.F. and Gordienko, S.P. (1985) Anti-Bodies to Calcitonin under Experimental Diabetes Mellitus. Bulletin of Experimental Biology and Medicine, 99, 422-424. https://doi.org/10.1007/BF00842732
Kosovskii, M.I., Khysainova, F.A. and Gulyamov, T.D. (1982) The Decreasing of Tissue Insulin Sensitivity in Rats after Hydrocortisone or Indometacine Injection, Correlation with Prostaglandin Effect. Pediatric Endocrinology Reviews, 28, 57-60.
Ertel, E.A., Campbell, K.P., Harpold, M.M., Hofmann, F., Mori, Y., Perez-Reyes, E., Schwartz, A., Snutch, T.P., Tanabe, T., Birnbaumer, L., Tsien, R.W. and Catterall, W.A. (2000) Nomenclature of Voltage-Gated Calcium Channels. Neuron, 25, 533-535. https://doi.org/10.1016/S0896-6273(00)81057-0
William O, W., Michael B, Z. and Naima, M.-M. (2003) Modulation of the Sulfonylurea Receptor and Calcium in Adipocyties for Treatment of Obesity/Diabetes. US Patent No. 6100047.
Byyny, R.L., Loverde, M., Llotd, S., Mitchell, W. and Draznin, B. (1992) Cytosolic Calcium and Insulin Resistance in Elderly Patients with Essential Hypertension. American Journal of Hypertension, 5, 459-464. https://doi.org/10.1093/ajh/5.7.459
Hagstrom, E., Hellman, P., Lundgren, E., Lind, L. and Arnlov, J. (2007) Serum Calcium Is Independently Associated with Insulin Sensitivity Measured with Euglycaemic-Hyperinsulinaemic Clamp in a Community Based Cohort. Diabetologia, 50, 317-324. https://doi.org/10.1007/s00125-006-0532-9
Kiseleva, T.P. (2008) Disturbances of Phosphorus-Calcium Metabolism under Diabetes Mellitus 1 Type. Proceedings 15th Russian National Congress Man and Drugs, Moscow, 18 April, 432-433.
Levy, J. (1999) Abnormal Cell Calcium Homeostasis in Type 2 Diabetes Mellitus: A New Look on Old Disease. Endocrine, 10, 1-6. https://doi.org/10.1385/ENDO:10:1:1
Advani, A., Marshall, S.M. and Thomas, T.H. (2004) Impaired Neutrophil Store-Mediated Calcium Entry in Type 2 Diabetes. European Journal of Clinical Investigation, 34, 43-49. https://doi.org/10.1111/j.1365-2362.2004.01291.x
Tytskaya Y.A. (2004) Bone Tissue Metabolism under Diabetes Mellitus in Children. Ph.D. Dissertation, Izhevsk State Medical Acad-emy, Izhevsk.
Falameeva, O.V. (2008) Scientific Bases of Preventive Measures of Osteoporosis in Childish, Ad-olescent and Youthful Age on Population Level. Ph.D. Dissertation, Novosibirsk Medical Institute, Novosibirsk.
op den Buijs, J., Miklos, Z., van Riel, N.A., Prestia, C.M., Szenczi, O., Toth, A., Van der Vusse, G.J., Szabo, C., Ligeti, L. and Ivanics, T. (2005) Beta-Adrenergic Activation Reveals Impaired Cardiac Calcium Handling at Early Stage of Diabetes. Life Science, 76, 1083-1098. https://doi.org/10.1016/j.lfs.2004.08.018
Ward, D.T., Yau, S.K., Mee, A.P., Mawer, E.B., Miller, C.A., Garland, H.O. and Riccardi, D. (2000) Functional and Molecular Characterization of Diabetic Hypercalciuria. Journal of Physiology and Proceeding, 527, 13.
Zhou, Z.-H., Zhuang, L.-Y. and Song, Y.-J. (2002) Effect of Nifedipin Therapy on Insulin Resistance in Elderly Patients with Hypertension. Chinese Journal of New Drugs and Clinical Remedies, 21, 491-492.
Wen, Z.-Y., Wu, Y., Li, Y., Chen, X.-L., Wang, T., Ouyang, J.-P. and Li, G.-S. (2005) Changing of GLUT-4 under Diabetes Mellitus 2 Type and Its Influence on Glucose and Fatty Acids in Myocardium. Chinese Medical Journal, 85, 1460-1463.
Mychka, V.B., Gornostaeva, V.V., Bogieva, R.M. and Chazova, I.E. (2001) Arterial Hypertension in Patients with Diabetes Mellitus and Metabolic Syndrome. Consilium Medicum. Arterial Hypertension, 1, 25-31.
Fel’dsherova N.A. and Semernin, E.N. (2002) Amlodipin: Review of Clinic Research. Qualitative Clinical Practice, 2, 27-33.
Chazova I.E. and Mychka, V.B. (2004) Calcium Channel Blockers. Metabolic Syndrome. Consilium Medicum, 4, 168.
Chazova I.E. and Mychka, V.B. (2008) Metabolic Syndrome. Media Medica, Moscow.
Butakova, S.S. and Nozdrachev, A.D. (2012) Calcium Channel Blockers Inhibit the Hyperglycemic Effect of Calcitonin. Bulletin of Experimental Biology and Medicine, 152, 553-559. https://doi.org/10.1007/s10517-012-1573-3
Mc Carty, M.F. (2006) PKC-Mediated Modulation of L-Type Calcium Channels May Contribute to Fat-Induced Insulin Resistance. Medical Hypotheses, 66, 824-831. https://doi.org/10.1016/j.mehy.2004.08.034
Hemandez, R.H., Armas-Hemandez, M.Y. and Velasco, M. (2003) Calcium Antagonists and Atherosclerosis Protection in Hypertension. American Journal of Therapeutics, 10, 409-414. https://doi.org/10.1097/00045391-200311000-00006
Shilova, E.V. and Martsevich S.Y. (2008) Dihydropyridine Calcium Antagonists: Role in Modern Therapy of Cardiovascular Diseases. Rational Pharmacotherapy in Cardiology, 2, 53-57. https://doi.org/10.20996/1819-6446-2008-4-2-53-57
Zanos, S., Mitsopoulos, E. and Sakellariou, G. (2005) Parathyroid Hormone Levels, Calcium-Channel Blockers, and the Dyslipidemia of Non-Diabetic Hemodialysis Patients. Renal Failure, 2, 163-169. https://doi.org/10.1081/JDI-48229
Vislobokov, A.I., Ignatov, Y.D., Galenko-Yaroshevskii, P.A. and Shabanov P.D. (2010) Membrane-Tropos Effect of Pharmacological Drugs. Enlightment-South, St.-Petersburg-Krasnodar.
Davalli, A.M., Biancardi, E., Pollo, A., Socci, C., Pontiroli, A.F., Pozza, G., Climinti, F., Sher, E. and Carbone, E. (1996) Dihydropyridine-Sensitive and -Insensitive Voltage-Operated Calcium Channels Participate in the Control of Glucose-Induced Insulin Release from Human Pancreatic ?-cells. Journal of Endocrinology, 150, 195-203. https://doi.org/10.1677/joe.0.1500195
Roe, M.W., Worley, J.F., Tokuyama, Y., Philipson, K.H., Sturis, J., Tang, J., Dukes, J.D., Bell, G.I. and Polonsky, K.S. (1997) NIDDM Is Associated with Loss of Pancreatic ?-Cell L-Type Ca2+ -Channel Activity. American Journal of Physiology, 270, 133-140.