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Antidiabetic and Antioxidant Effects of Methanolic Extracts of Leaf and Seed of <i>Tetracarpidium conophorum</i> on Alloxan-Induced Diabetic Wistar Rats
Department of Biochemistry, Faculty of Medical Sciences, University of Jos, Jos, Nigeria
Depatment of Haematology and Immunology, Obafemi Awolowo University, Ile-Ife, Nigeria
- 1 Department of Biochemistry, Faculty of Medical Sciences, University of Jos, Jos, Nigeria
- 2 Depatment of Haematology and Immunology, Obafemi Awolowo University, Ile-Ife, Nigeria
Journal of Biomedical Science and Engineering·Volume 10 (2017)·Pages 402–420·Published 26 July 2017·DOI10.4236/jbise.2017.108031
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Abstract
Methanolic extracts of Tetracarpidium conophorum (TCME) leaf, seed or leaf + seed extract demonstrated high capacity for reversing hyperglycemia and oxidative stress comparable with the standard anti-diabetic drug, metformin, in alloxan-induced diabetic rats. The leaf + seed extracts showed the best activity among the extracts and also ameliorated oxidative stress-induced damage of pancreas and liver tissue to normal state.
KeywordsAntidiabeticGlucoseMDAGSHLipids<i>T. conophorum</i>
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