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Electrospun PLLA Membranes for Caffeine Delivery: Diffusional Approach
Institut d’Investigació Tèxtil i Cooperació Industrial de Terrassa, Universitat Politècnica de Catalunya, Terrassa, Spain
Institut d’Investigació Tèxtil i Cooperació Industrial de Terrassa, Universitat Politècnica de Catalunya, Terrassa, Spain
Institut d’Investigació Tèxtil i Cooperació Industrial de Terrassa, Universitat Politècnica de Catalunya, Terrassa, Spain
Chemical Engineering Department, Universitat Politècnica de Catalunya, Terrassa, Spain
- 1 Institut d’Investigació Tèxtil i Cooperació Industrial de Terrassa, Universitat Politècnica de Catalunya, Terrassa, Spain
- 2 Institut d’Investigació Tèxtil i Cooperació Industrial de Terrassa, Universitat Politècnica de Catalunya, Terrassa, Spain
- 3 Institut d’Investigació Tèxtil i Cooperació Industrial de Terrassa, Universitat Politècnica de Catalunya, Terrassa, Spain
- 4 Chemical Engineering Department, Universitat Politècnica de Catalunya, Terrassa, Spain
Journal of Biomedical Science and Engineering·Volume 10 (2017)·Pages 563–574·Published 28 December 2017·DOI10.4236/jbise.2017.1012042
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Abstract
One of the great advantages of electrospun fibers is the large tridimensional area produced, capable of storing any type of material. The aim of our investigation is to study the electrospinning technique to produce polymer membranes for drug delivery applications, given their large surface area and ability to transport a bioactive compound. A mathematical modeling of the delivery system kinetics was also studied to find the mechanism that controls the releasing process. Results showed that electrospinning could provide regular and smooth membranes suitable for drug delivery processes. The mathematical modeling also proved that thicker PLLA membranes exhibited a Fickian diffusion behavior during the drug transport, presenting better control in drug delivery processes.
KeywordsDiffusionPolymerNano EscaleKinetics
- Loos, M. (2015) Carbon Nanotube Reinforced Composites. CNR Polymer Science and Technology Elsevier, Oxford, 304.
- Huang, Z.M., Zhang, Y.Z., Kotaki, M. and Ramakrishna, S. (2003) A Review on Polymer Nanofibers by Electrospinning and Their Applications in Nanocomposites. Composites Science and Technology, 63, 2223-2253. https://doi.org/10.1016/S0266-3538(03)00178-7
- Chilkoti, A., McDaniel, J.R. and Callahan, D.J. (2010) Drug Delivery to Solid Tumors by Elastin-Like Polypeptides. Advanced Drug Delivery Reviews, 62, 1456-1467. https://doi.org/10.1016/j.addr.2010.05.004
- Li, F., Zhu, Y. and Wang, Y. (2014) Dual-Responsive Drug Delivery System with Real Time Tunable Release Behavior. Microporous and Mesoporous Materials, 200, 46-51. https://doi.org/10.1016/j.micromeso.2014.07.060
- Ifuku, S., Ikulta, A., Izawa, H., Morimoto, M. and Saimoto, H. (2014) Control of Mechanical Properties of Chitin Nanofiber Film Using Glycerol without Losing Its Characteristics. Carbohydrate Polymers, 101, 714-717. https://doi.org/10.1016/j.carbpol.2013.09.076
- Whitesides, G.M. and Grzybowski, B. (2002) Self-Assembly at All Scales. Science, 295, 2418-2421. https://doi.org/10.1126/science.1070821
- Youg, Y., Wang, S., Wang, Y., Wang, X., Wang, Q. and Chen, M. (2014) Advances in Self-Assembled Chitosan Nanomaterials for Drug Delivery. Biotechnology Advances, 32, 1301-1316. https://doi.org/10.1016/j.biotechadv.2014.07.007
- Hu, X., Liu, S., Zhou, G., Huang, Y., Xie, Z. and Jing, X. (2014) Electrospinning of Polymeric Nanofibers for Drug Delivery Applications. Journal of Controlled Release, 185, 12-21. https://doi.org/10.1016/j.jconrel.2014.04.018
- Rogina, A. (2014) Electrospinning Process: Versatile Preparation Method for Biodegradable and Natural Polymers and Biocomposite Systems Applied in Tissue Engineering and Drug Delivery. Applied Surface Science, 296, 221-230. https://doi.org/10.1016/j.apsusc.2014.01.098
- Agrawal, S., Wendorff, J.H. and Grenier, A. Use of Electrospinning Technique for Biomedical Applications. Polymer, 49, 5603.
- Nandana, B. and Subhas, C.K. (2010) Electrospinning: A Fascinating Fiber Fabrication Technique. Biotechnology Advances, 28, 325-347. https://doi.org/10.1016/j.biotechadv.2010.01.004
- Peer, P., Stenicka, M., Pavlinek, V., Filip, P., Kuritka, I. and Brus, J. (2014) An Electrorheological Investigation of PVB Solutions in Connection with Their Electrospinning Qualities. Polymer Testing, 39, 115-121. https://doi.org/10.1016/j.polymertesting.2014.07.016