Cardiovascular Haemodynamics and Some Biochemical Profiles of Endotoxemic Buffalo Calves on Infusion of HSS, Flunixin Meglumine & Blood

Abstract

Six apparently healthy male buffalo calves aged between 6 months to one year with body weight range of 70 - 140 Kg were used in the present investigation. One animal was used for pilot trial for this group. Five calves were randomly taken into this group. The Eschrechia coli endotoxin infused i/v @5 mg/kg BW/hr for 3 hours to all the animals caused symptoms of restlessness, respiratory distress, snoring, diarrhea, profuse salivation along with the significant fall in systolic, diastolic, pulse and mean arterial venous pressure, hypoproteinemia at 1, 2 & 3 hour and hypoglycemia at 3rd hour i.e. , end of endotoxin infusion. Respiration was increased significantly during endotoxin infusion at 2 nd & 3 rd hour and even afterwards till the end of the observation period i.e. 7 hrs. The treatment with hypertonic saline solution, flunixin meglumine and blood raised (p < 0.05) the systolic, diastolic, pulse, mean arterial, central venous pressure, plasma total protein, Albumin, Glucose and Creatinine to levels either close to or even higher than the normal pre-infusion levels while hematocrit and hemoglobin increased significantly at 7th hour and at 5 th , 6 th & 7 th hour respectively i.e. , till the end of the observation period. There was no significant effect on Central Venous Pressure (CVP) and body temperature as measured from rectum.