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Rapid and Non-Invasive Screening System for Early Detection of Diabetic Retinopathy via Auto Fluorescence of <i>Falvin</i> Proteins
Department of Medical Information, Chongqing Medical University, Chongqing, China
Department of Medical Information, Chongqing Medical University, Chongqing, China
Department of Biochemistry and Molecular Biology, Chongqing Medical University, Chongqing, China
- 1 Department of Medical Information, Chongqing Medical University, Chongqing, China
- 2 Department of Medical Information, Chongqing Medical University, Chongqing, China
- 3 Department of Biochemistry and Molecular Biology, Chongqing Medical University, Chongqing, China
Journal of Biomedical Science and Engineering·Volume 11 (2018)·Pages 215–224·Published 14 August 2018·DOI10.4236/jbise.2018.118017
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Abstract
Diabetic retinopathy is one of the most serious complications of diabetes, which is also one of the most important causes of blindness around the world. Autofluorescence of flavin protein in retinal pigment epithelial cells is considered as a marker of early tissue damage. This study was designed to image spontaneous fluorescence of falvin proteins in fundus macular center area. The average intensity of the fluorescence signal and the characteristics of the histogram distribution were obtained and the significant differences in the fluorescence signals between the diabetic and the normal people were also compared with statistical methods, and then a rapid and non-invasive screening method and equipment for early detection of diabetic retinopathy were developed.
KeywordsDiabetic RetinopathyFundus MacularFlavin ProteinAutofluorescence
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