New Insight into Microvascular Perfusion by Analyzing Pipe Flow in a Cylindrical Elastic Shell
- 1 Department of Orthopaedics, The Fifth People’s Hospital, Jinan, China;
- 2 Shandong Experimental High School, Jinan, China
- 3 Department of Nursing, The Fifth People’s Hospital, Jinan, China
- 4 Department of Infectious Diseases, Center for Disease Control and Prevention, Jinan, China
Abstract
Background: Microvascular perfusion, a kind of regional perfusion, plays important roles in delivering oxygen and nutrients, and regulating blood pressure and responses to inflammation. Aim: The aim of this research is to analyze the characteristics of microvascular perfusion by conducting pipe flow in a circular elastic tube. Methods: A model was established with circular elastic tube to mimic microvascular perfusion. The velocity of pressure waves was calculated according to the time that the liquid took to spilt over. What’s more, the characteristics and significance of microvascular flow and arteriovenous anastomoses (AVAs) were analyzed. Results: It took the liquid about 0.1 second to spill over from the model, and the velocity of pressure waves is greater than 100 m/s in the elastic pipe. A mechanical switch structure and the corresponding mechanism were proposed for microvascular perfusion in AVAs. Conclusion: Microvascular perfusion maintains a considerable constancy of hemodynamics in different tissues, when ventricular contraction changes perfusion pressure to meet metabolic demands appropriately. This theory will help us to gain a new perspective in microvascular flow.
- Katanov, D., Gompper, G. and Fedosov, D.A. (2015) Microvascular Blood Flow Resistance: Role of Red Blood Cell Migration and Dispersion. Microvascular Research, 99, 57-66. https://doi.org/10.1016/j.mvr.2015.02.006
- Chan, H.Y. and Lubchenko, V. (2015) Pressure in the Landau-Ginzburg Functional: Pascal’s Law, Nucleation in Fluid Mixtures, a Meanfield Theory of Amphiphilic Action, and Interface Wetting in Glassy Liquids. The Journal of Chemical Physics, 143, 124502. https://doi.org/10.1063/1.4931177
- Godinho, L., Tadeu, A. and Branco, F.J.G. (2004) Dynamic Analysis of Submerged Fluid-Filled Pipelines Subjected to a Point Pressure Load. Journal of Sound & Vibration, 271, 257-277. https://doi.org/10.1016/S0022-460X(03)00752-1
- Drawz, P.E., Abdalla, M. and Rahman, M. (2012) Blood Pressure Measurement: Clinic, Home, Ambulatory, and Beyond. American Journal of Kidney Diseases, 60, 449-462. https://doi.org/10.1053/j.ajkd.2012.01.026
- Willemet, M. and Alastruey, J. (2015) Arterial Pressure and Flow Wave Analysis Using Time-Domain 1-D Hemodynamics. Annals of Biomedical Engineering, 43, 190-206. https://doi.org/10.1007/s10439-014-1087-4
- Lin, T.C. and Morgan, G.W. (1956) Wave Propagation through Fluid Contained in a Cylindrical, Elastic Shell. Journal of the Acoustical Society of America, 28, 1165-1176. https://doi.org/10.1121/1.1908583
- Peltokangas, M., Vehkaoja, A., Verho, J., Huotari, M., Roning, J. and Lekkala, J. (2014) Monitoring Arterial Pulse Waves with Synchronous Body Sensor Network. IEEE Journal of Biomedical and Health Informatics, 18, 1781-1787. https://doi.org/10.1109/JBHI.2014.2328788
- Nemcsik, J., Cseprekal, O. and Tisler, A. (2017) Measurement of Arterial Stiffness: A Novel Tool of Risk Stratification in Hypertension. Advances in Experimental Medicine and Biology, 956, 475-488.
- Allen, J. (2007) Photoplethysmography and Its Application in Clinical Physiological Measurement. Physiological Measurement, 28, R1-39. https://doi.org/10.1088/0967-3334/28/3/R01
- Huang, T.C., Lin, W.C., Wu, C.C., Zhang, G. and Lin, K.P. (2010) Experimental Estimation of Blood Flow Velocity through Simulation of Intravital Microscopic Imaging in Micro-Vessels by Different Image Processing Methods. Microvascular Research, 80, 477-483. https://doi.org/10.1016/j.mvr.2010.07.007
- Hu, Y. (2013) Flow Resistance of Vessels with an Enlarged Total Cross-Sectional Area in the Midsection. Open Circulation & Vascular Journal, 6, 9-12. https://doi.org/10.2174/1877382601306010009