Research ArticleOpen AccessGoogle Scholar indexed
Hypoxic Condition Up-Regulates the Expression of Angiopoietin-2 in ADSCs
Department of Plastic and Reconstructive Surgery, The Ninth People’s Hospital Affiliated to School of Medicine Shanghai Jiao Tong University, Shanghai, China
Department of Plastic and Reconstructive Surgery, The Ninth People’s Hospital Affiliated to School of Medicine Shanghai Jiao Tong University, Shanghai, China
Department of Plastic and Reconstructive Surgery, The Ninth People’s Hospital Affiliated to School of Medicine Shanghai Jiao Tong University, Shanghai, China
Department of Plastic and Reconstructive Surgery, The Ninth People’s Hospital Affiliated to School of Medicine Shanghai Jiao Tong University, Shanghai, China
- 1 Department of Plastic and Reconstructive Surgery, The Ninth People’s Hospital Affiliated to School of Medicine Shanghai Jiao Tong University, Shanghai, China
- 2 Department of Plastic and Reconstructive Surgery, The Ninth People’s Hospital Affiliated to School of Medicine Shanghai Jiao Tong University, Shanghai, China
- 3 Department of Plastic and Reconstructive Surgery, The Ninth People’s Hospital Affiliated to School of Medicine Shanghai Jiao Tong University, Shanghai, China
- 4 Department of Plastic and Reconstructive Surgery, The Ninth People’s Hospital Affiliated to School of Medicine Shanghai Jiao Tong University, Shanghai, China
Journal of Biomedical Science and Engineering·Volume 12 (2019)·Pages 77–84·Published 21 February 2019·DOI10.4236/jbise.2019.122006
Copy link · social · email
Abstract
Wound healing requires abundant nutrition and blood supply, thus angiogenesis is a vital stage in this process. Angiogenesis involves diverse kinds of immune cells, growth factors, cytokines and inhibitors. ADSCs, especially ADSCs cultured in hypoxic condition, are reported to be able to facilitate angiogenesis and promote wound healing process. Significant efforts have been made on the development of ADSCs-based therapies with wound-healing applications. Here the results showed that expression of Angiopoietin-2 (ANGPT2) in ADSCs was up-regulated in the hypoxic condition.
KeywordsADSCsANGPT2AngiogenesisWound Healing
- Eming, S.A., Martin, P. and Tomic-Canic, M. (2014) Wound Repair and Regeneration: Mechanisms, Signaling, and Translation. Science Translational Medicine, 6, 265sr6. https://doi.org/10.1126/scitranslmed.3009337
- Eming, S.A., Brachvogel, B., Odorisio, T. and Koch, M. (2007) Regulation of Angiogenesis: Wound Healing as a Model. Progress in Histochemistry and Cytochemistry, 42, 115-170. https://doi.org/10.1016/j.proghi.2007.06.001
- Brem, H. and Tomic-Canic, M. (2007) Cellular and Molecular Basis of Wound Healing in Diabetes. Journal of Clinical Investigation, 117, 1219-1222. https://doi.org/10.1172/JCI32169
- Kim, W.S., Park, B.S., Sung, J.H., Yang, J.M., Park, S.B., Kwak, S.J. and Park, J.S. (2007) Wound Healing Effect of Adipose-Derived Stem Cells: A Critical Role of Secretory Factors on Human Dermal Fibroblasts. Journal of Dermatological Science, 48, 15-24. https://doi.org/10.1016/j.jdermsci.2007.05.018
- Hu, J.H., Srivastava, K., Wieland, M., Runge, A., Mogler, C., Besemfelder, E., Terhardt, D., Vogel, M.J., Cao, L.J., Korn, C., Bartels, S., Thomas, M. and Augustin, H.G. (2014) Endothelial Cell-Derived Angiopoietin-2 Controls Liver Regeneration as a Spatiotemporal Rheostat. Science, 343, 416-419. https://doi.org/10.1126/science.1244880
- Bauer, S.M., Bauer, R.J. and Velazquez, O.C. (2005) Angiogenesis, Vasculogenesis, and Induction of Healing in Chronic Wounds. Vascular and Endovascular Surgery, 39, 293-306. https://doi.org/10.1177/153857440503900401
- Faghih, H., Javeri, A. and Taha, M.F. (2017) Impact of Early Subcultures on Stemness, Migration and Angiogenic Potential of Adipose Tissue-Derived Stem Cells and Their Resistance to in Vitro Ischemic Condition. Cytotechnology, 69, 885-900. https://doi.org/10.1007/s10616-017-0104-5
- Cao, Y., Sun, Z., Liao, L., Meng, Y., Han, Q. and Zhao, R.C. (2005) Human Adipose Tissue-Derived Stem Cells Differentiate into Endothelial Cells in Vitro and Improve Postnatal Neovascularization in Vivo. Biochemical and Biophysical Research Communications, 332, 370-379. https://doi.org/10.1016/j.bbrc.2005.04.135
- Gimble, J.M., Katz, A.J. and Bunnell, B.A. (2007) Adipose-Derived Stem Cells for Regenerative Medicine. Circulation Research, 100, 1249-1260. https://doi.org/10.1161/01.RES.0000265074.83288.09
- Flegg, J.A., Menon, S.N., Maini, P.K. and McElwain, D.L. (2015) On the Mathematical Modeling of Wound Healing Angiogenesis in Skin as a Reaction-Transport Process. Frontier in Physiology, 6, 262.