Nanoskin ® -ACT—The Impact of Natural Membrane & Soft with Chronic and Untreated Wounds
- 1 Qassimi Hospital, GEM International, Sharjah, United Arab Emirates
- 2 Qassimi Hospital, GEM International, Sharjah, United Arab Emirates
- 3 Qassimi Hospital, GEM International, Sharjah, United Arab Emirates
- 4 Qassimi Hospital, GEM International, Sharjah, United Arab Emirates
- 5 Qassimi Hospital, GEM International, Sharjah, United Arab Emirates
- 6 Innovatec’s-Biotechnology Research and Development, São Carlos, Brazil
- 7 Innovatec’s-Biotechnology Research and Development, São Carlos, Brazil
- 8 UNESP-IQ-Physical Chemistry Department, Araraquara, Brazil
Abstract
Bacterial cellulose (BC) is a versatile biomaterial with unique properties that make it promising for various biomedical applications, including wound healing. The extracellular matrix (ECM) plays a crucial role in wound healing, providing a structural scaffold and signaling cues for cell migration and proliferation. This study investigates the potential of BC as a scaffold for ECM production and its effect on in vivo wound healing. In this work, the bacterial cellulose fermentation process is modified by the addition of Green Propolis and Usnic acid to the culture medium and natural materials before the bacteria are inoculated. In vivo behaviour using natural membranes for regenerative medicine is presented and it is in edit. Overall, our findings demonstrate the potential of BC as a scaffold for ECM production and its beneficial effects on in vivo wound healing. BC-based dressings may offer a novel approach to promoting wound healing and tissue regeneration in clinical settings. Further studies are warranted to optimize BC-based therapies and explore their full potential in regenerative medicine.
- Olyveira, G.M., Costa, L.M.M., Riccardi, C.S., Santos, M.L., Daltro, P.B., Basmaji, P., Daltro, G.C. and Guastaldi, A.C. (2016) Bacterial Cellulose for Advanced Medical Materials. In: Grumezescu, A.M., Ed., Nanobiomaterials in Soft Tissue Engineering , William Andrew, 57-82. https://doi.org/10.1016/B978-0-323-42865-1.00003-9
- de Olyveira, G.M., dos Santos, M.L., Costa, L.M.M., Daltro, P.B., Basmaji, P., de Cerqueira Daltro, G., et al . (2014) Bacterial Cellulose Biocomposites for Guided Tissue Regeneration. Science of Advanced Materials , 6, 2673-2678. https://doi.org/10.1166/sam.2014.1985
- de Olyveira, G.M., dos Santos, M.L., dos Santos Riccardi, C., Costa, L.M.M., Daltro, P.B., Basmaji, P., et al . (2015) Physically Modified Bacterial Cellulose Biocomposites for Guided Tissue Regeneration. Science of Advanced Materials , 7, 1657-1664. https://doi.org/10.1166/sam.2015.2283
- de Olyveira, G.M., Basmaji, P., Costa, L.M.M., dos Santos, M.L., dos Santos Riccardi, C., Guastaldi, F.P.S., et al . (2017) Surface Physical Chemistry Properties in Coated Bacterial Cellulose Membranes with Calcium Phosphate. Materials Science and Engineering : C , 75, 1359-1365. https://doi.org/10.1016/j.msec.2017.03.025
- Kaminagakura, K.L.N., Sue Sato, S., Sugino, P., Kataki de Oliveira Veloso, L., dos Santos, D.C., Padovani, C.R., et al . (2018) Nanoskin® to Treat Full Thickness Skin Wounds. Journal of Biomedical Materials Research Part B : Applied Biomaterials , 107, 724-732. https://doi.org/10.1002/jbm.b.34166
- Viveiros, M.M.H., Rainho, C.A., Ramirez, J.A.Z., Kaneno, R., Silva, M.G., Ximenes, V.F., de Olyveira, G.M., Basmaji, P., Di Girolamo, N. and Schellini, S.A. (2022) Physical, Functional and Biochemical Features of Nanoskin® bacterial Cellulose Scaffold as a Potential Carrier for Cell Transference. Materials Letters , 308, Article 131109. https://doi.org/10.1016/j.matlet.2021.131109
- Basmaji, P., Molina de Olyveira, G. and Kanjou, M.M. (2021) Skin Cancer Treatment by Nanoskin Cellulose: Future Cancer Wound Healing. Journal of Biomat e rials and Nanobiotechnology , 12, 1-6. https://doi.org/10.4236/jbnb.2021.121001
- Al Mualla, S., Al Nabooda, M., Salman, N.S., Basmaji, P., De Olyveira, G.M., Manzine Costa, L.M., et al . (2018) Special Nanoskin-ACT-Biological Membranes from Deep Wounds. Journal of Biomaterials and Nanobiotechnology , 9, 79-88. https://doi.org/10.4236/jbnb.2018.91007
- Kanjou, M.M., Abdulhakim, H., Molina de Olyveira, G. and Basmaji, P. (2019) 3-D Print Celulose Nanoskin: Future Diabetic Wound Healing. Journal of Biomaterials and Nanobiotechnology , 10, 190-195. https://doi.org/10.4236/jbnb.2019.104011