Orange and citrus peel, often considered agro-industrial waste, are rich sources of bioactive compounds such as flavonoids, polyphenols, essential oils, and dietary fibers. This review comprehensively discusses the chemical composition and functional properties of orange peel, highlighting enzymatic biotransformation and advanced extraction strategies including ultrasound-, microwave-, and enzyme-assisted techniques. Special attention is given to green extraction approaches using deep eutectic solvents for sustainable recovery of hydrophilic and lipophilic bioactive compounds. The functional applications of orange peel-derived compounds in food, nutrition, pharmaceuticals, cosmetics, agriculture, and industrial materials are also presented, emphasizing their potential in developing eco-friendly biobased products and active food packaging. By integrating chemical profiling, sustainable extraction methods, and multifunctional applications, this review provides a systematic overview of the valorization of orange and citrus peel waste, promoting circular bioeconomy approaches and environmental sustainability.
U.S. Department of Agriculture (2025) Production-Oranges. https://www.fas.usda.gov/data/production/commodity/0571120
Lombardi, P., Barbero, S., Fiore, S., Orlandella, I., Rovera, F., Todella, E., et al . (2025). Orange Peel Waste in the Circular Economy: An Integrated Assessment Approach. Proceedings , 131, Article 14. https://doi.org/10.3390/proceedings2025131014
Habiba, U., Singh, R., Pathare, P.B., Dar, A.H., Manzoor, M., Sidiqi, U.S., et al . (2025) Exploring the Bioactive Potential of Fruit Peels: A Comprehensive Review. Food Chemistry Advances , 9, Article ID: 101136. https://doi.org/10.1016/j.focha.2025.101136
Gómez-Mejía, E., Dias, M.I., Pereira, C., Pires, T.C.S.P., Palá-Paúl, J., Rosales-Conrado, N., et al. (2025) A Biorefinery Approach for the Simultaneous Obtention of Essential Oils, Organic Acids and Polyphenols from Citrus Peels: Phytochemical Characterization and Bioactive Potential. Food Chemistry , 486, Article ID: 144641. https://doi.org/10.1016/j.foodchem.2025.144641
Ferhat, M.A., Meklati, B.Y., Smadja, J. and Chemat, F. (2006) An Improved Microwave Clevenger Apparatus for Distillation of Essential Oils from Orange Peel. Journal of Chromatography A , 1112, 121-126. https://doi.org/10.1016/j.chroma.2005.12.030
Bratovcic, A. and Dautovic, A. (2024) Green Synthesis of Silver Nanoparticles Using Aqueous Orange and Lemon Peel Extract and Evaluation of Their Antimicrobial Properties. Advances in Nanoparticles , 13, 11-28. https://doi.org/10.4236/anp.2024.132002
Ortiz-Sanchez, M., Cardona Alzate, C.A. and Solarte-Toro, J.C. (2024) Orange Peel Waste as a Source of Bioactive Compounds and Valuable Products: Insights Based on Chemical Composition and Biorefining. Biomass , 4, 107-131. https://doi.org/10.3390/biomass4010006
Sabry, B.A., Badr, A.N., Mohammed, D.M., Desoukey, M.A. and Farouk, A. (2024) Validating the Protective Role of Orange and Tangerine Peel Extracts Foramending Food Safety against Microorganisms’ Contamination Using Molecular Docking. Heliyon , 10, e27737. https://doi.org/10.1016/j.heliyon.2024.e27737
Bratovcic, A. (2023) Green Synthesis of Various Nanostructures Containing Essential Oil and Silver Nanoparticles: Nanocomposites, Nanoemulsions and Nanoencapsules. International Journal of Engineering Research and Applications , 13, 234-242.
Ahmed, O.M., Hassan, M.A., Abdel-Twab, S.M. and Abdel Azeem, M.N. (2017) Navel Orange Peel Hydroethanolic Extract, Naringin and Naringenin Have Anti-Diabetic Potentials in Type 2 Diabetic Rats. Biomedicine & Pharmacotherapy , 94, 197-205. https://doi.org/10.1016/j.biopha.2017.07.094
Ramesh, P., Jagadeesan, R., Sekaran, S., Dhanasekaran, A. and Vimalraj, S. (2021) Flavonoids: Classification, Function, and Molecular Mechanisms Involved in Bone Remodelling. Frontiers in Endocrinology , 12, Article 779638. https://doi.org/10.3389/fendo.2021.779638
Shilpa, V., Shams, R., Dash, K.K., Pandey, V.K., Dar, A.H., Ayaz Mukarram, S., et al . (2023) Phytochemical Properties, Extraction, and Pharmacological Benefits of Naringin: A Review. Molecules , 28, Article 5623. https://doi.org/10.3390/molecules28155623
González-Temiño, Y., Ortega, N. and Busto, M.D. (2020) Optimización de la inmovilización de naringinasa en criogeles de alcohol polivinílico y polietilenglicol. Información tecnológica , 31, 29-40. https://doi.org/10.4067/s0718-07642020000100029
Rafiq, S., Kaul, R., Sofi, S.A., Bashir, N., Nazir, F. and Ahmad Nayik, G. (2018) Citrus Peel as a Source of Functional Ingredient: A Review. Journal of the Saudi Society of Agricultural Sciences , 17, 351-358. https://doi.org/10.1016/j.jssas.2016.07.006
Zhang, W., Fu, X., Zhang, Y., Chen, X., Feng, T., Xiong, C., et al . (2024) Metabolome Comparison of Sichuan Dried Orange Peels (Chenpi) Aged for Different Years. Horticulturae , 10, Article 421. https://doi.org/10.3390/horticulturae10040421
Puttongsiri, T., Manichart, N., Teerarak, M., Sikhao, P., Somala, N., Tongsri, P., et al . (2025) Siamese Neem Tree as a Natural Preservative: Chemical Profile, Antioxidant Properties, and Antibacterial Efficacy against Foodborne Pathogens and Spoilage Bacteria. Journal of Agriculture and Food Research , 19, Article ID: 101559. https://doi.org/10.1016/j.jafr.2024.101559
Forner-Giner, M.Á., Ballesta-de los Santos, M., Melgarejo, P., Martínez-Nicolás, J.J., Gómez-Pérez, R., Continella, A., et al . (2025) Comparative Study of Rootstock Effects on Primary and Secondary Metabolites Content in Blood Orange Peel: Potential Co-Product Perspectives. Scientia Horticulturae , 342, Article ID: 114042. https://doi.org/10.1016/j.scienta.2025.114042
Prayoga, D., Aulifa, D., Budiman, A., Levita, J. and Jiranusornkul, S. (2025) Cyanidin and Cyanidin-3-Glucoside Alleviate Peptic Ulcer Disease: Insights from in Vitro , and in Vivo Studies. Drug Design , Development and Therapy , 19, 841-856. https://doi.org/10.2147/dddt.s500645
Zheng, Y., Wu, Y., Wang, B., Wang, H., Zhang, Y., Wang, W., et al . (2024) Flavonoids Analysis in Citrus Peels by UPLC-Q-TOF-MS/MS and Its Antioxidant and Anti-Inflammation Activity. Food Chemistry Advances , 5, Article ID: 100853. https://doi.org/10.1016/j.focha.2024.100853
Sang, J., Li, L., Wen, J., Gu, Q., Wu, J., Yu, Y., et al . (2021) Evaluation of the Structural, Physicochemical and Functional Properties of Dietary Fiber Extracted from Newhall Navel Orange By-Products. Foods , 10, Article 2772. https://doi.org/10.3390/foods10112772
Kaderides, K., Kyriakoudi, A., Mourtzinos, I. and Goula, A.M. (2021) Potential of Pomegranate Peel Extract as a Natural Additive in Foods. Trends in Food Science & Technology , 115, 380-390. https://doi.org/10.1016/j.tifs.2021.06.050
Yu, L., Wen, D., Tan, M., Wang, B., Wu, W. and Zhang, Y. (2024) Physicochemical and Structural Properties of Soluble Dietary Fibres in Navel Orange Peel Modified by Superfine Grinding and Their Immunomodulatory Activities. Food Chemistry Advances , 5, Article ID: 100752. https://doi.org/10.1016/j.focha.2024.100752
(2005) Real Farmacopea Española. 3a Ed. https://www.boe.es/eli/es/o/2005/09/30/sco3129
Guo, J., Mäkinen, M. and Jänis, J. (2025) Comprehensive Chemical Profiling of Citrus Peel Essential Oils by Direct‑Infusion Ultrahigh‑Resolution FT-ICR MS and High‑Resolution GC-QTOF Ms. Journal of Food Composition and Analysis , 148, Article ID: 108204. https://doi.org/10.1016/j.jfca.2025.108204
Umano, K., Hagi, Y. and Shibamoto, T. (2002) Volatile Chemicals Identified in Extracts from Newly Hybrid Citrus, Dekopon ( Shiranuhi mandarin Suppl. J.). Journal of Agricultural and Food Chemistry , 50, 5355-5359. https://doi.org/10.1021/jf0203951
Bouyahya, A., Mechchate, H., Benali, T., Ghchime, R., Charfi, S., Balahbib, A., et al . (2021) Health Benefits and Pharmacological Properties of Carvone. Biomolecules , 11, Article 1803. https://doi.org/10.3390/biom11121803
Chen, L., Hu, Q., Li, G., Zhang, L., Qin, L., Zuo, H., et al . (2021) Dietary Intake and Biomarkers of α -Linolenic Acid and Mortality: A Meta-Analysis of Prospective Cohort Studies. Frontiers in Nutrition , 8, Article 743852. https://doi.org/10.3389/fnut.2021.743852
Reifen, R., Karlinsky, A., Stark, A.H., Berkovich, Z. and Nyska, A. (2015) Α -Linolenic Acid (ALA) Is an Anti-Inflammatory Agent in Inflammatory Bowel Disease. The Journal of Nutritional Biochemistry , 26, 1632-1640. https://doi.org/10.1016/j.jnutbio.2015.08.006
Huang, W., Tsai, T., Chuang, L., Li, Y., Zouboulis, C.C. and Tsai, P. (2014) Anti-bacterial and Anti-Inflammatory Properties of Capric Acid against Propionibacterium Acnes: A Comparative Study with Lauric Acid. Journal of Dermatological Science , 73, 232-240. https://doi.org/10.1016/j.jdermsci.2013.10.010
Koolaji, N., Shammugasamy, B., Schindeler, A., Dong, Q., Dehghani, F. and Valtchev, P. (2020) Citrus Peel Flavonoids as Potential Cancer Prevention Agents. Current Developments in Nutrition , 4, nzaa025. https://doi.org/10.1093/cdn/nzaa025
Garzón-Alonso, K.E., Bohorquez-Peña, M.J., Vargas-Suaza, B., Rendón-Londoño, J.C., Mesa, M., Franco-Tobón, Y.N., et al. (2025) Hydrolysis of Flavanones from Orange Peel and Evaluation of Anticancer Potential Using Naringinase Immobilized on Corn Cob Powder. Food Bioscience , 69, Article ID: 106752. https://doi.org/10.1016/j.fbio.2025.106752
Niglio, S., Razola-Díaz, M.d.C., Waegeman, H. and Verardo, V. (2024) Food Grade Pilot Scale Strategy for Non-Thermal Extraction and Recovery of Phenolic Compounds from Orange Peels. LWT , 205, Article ID: 116538. https://doi.org/10.1016/j.lwt.2024.116538
Wang, Z., Mei, X., Chen, X., Rao, S., Ju, T., Li, J., et al . (2023) Extraction and Recovery of Bioactive Soluble Phenolic Compounds from Brocade Orange ( Citrus sinensis ) Peels: Effect of Different Extraction Methods Thereon. LWT , 173, Article ID: 114337. https://doi.org/10.1016/j.lwt.2022.114337
Peron, G., Bernabé, G., Marcheluzzo, S., Zengin, G., Ibrahime Sinan, K., Hošek, J., et al . (2024) Orange Fruit Peels from PDO Varieties of Ribera (Sicily, Italy): An Insight into the Chemistry and Bioactivity of Volatile and Non-Volatile Secondary Metabolites Extracted Using a Microwave-Assisted Method. Journal of Functional Foods , 116, Article ID: 106147. https://doi.org/10.1016/j.jff.2024.106147
Chemat, F., Abert-Vian, M., Fabiano-Tixier, A.S., Strube, J., Uhlenbrock, L., Gunjevic, V., et al . (2019) Green Extraction of Natural Products. Origins, Current Status, and Future Challenges. TrAC Trends in Analytical Chemistry , 118, 248-263. https://doi.org/10.1016/j.trac.2019.05.037
Gullón, P., Gullón, B., Romaní, A., Rocchetti, G. and Lorenzo, J.M. (2020) Smart Advanced Solvents for Bioactive Compounds Recovery from Agri-Food By-Products: A Review. Trends in Food Science & Technology , 101, 182-197. https://doi.org/10.1016/j.tifs.2020.05.007
Smith, E.L., Abbott, A.P. and Ryder, K.S. (2014) Deep Eutectic Solvents (DESs) and Their Applications. Chemical Reviews , 114, 11060-11082. https://doi.org/10.1021/cr300162p
Mitar, A., Panić, M., Radošević, K., Radojčić Redovniković, I., Zagajski Kučan, K., Sander, A., et al . (2019) Physicochemical Properties, Cytotoxicity, and Antioxidative Activity of Natural Deep Eutectic Solvents Containing Organic Acid. Chemical & biochemical engineering quarterly , 33, 1-18. https://doi.org/10.15255/cabeq.2018.1454
Gómez-Urios, C., Viñas-Ospino, A., Puchades-Colera, P., López-Malo, D., Frígola, A., Esteve, M.J., et al. (2022) Sustainable Development and Storage Stability of Orange By-Products Extract Using Natural Deep Eutectic Solvents. Foods , 11, Article 2457. https://doi.org/10.3390/foods11162457
Viñas-Ospino, A., Panić, M., Bagović, M., Radošević, K., Esteve, M.J. and Radojčić Redovniković, I. (2023) Green Approach to Extract Bioactive Compounds from Orange Peel Employing Hydrophilic and Hydrophobic Deep Eutectic Solvents. Sustainable Chemistry and Pharmacy , 31, Article ID: 100942. https://doi.org/10.1016/j.scp.2022.100942
Delgado-Cortez, A., Castillo-Zacarias, C., Juárez-Ramírez, I., Galindo-Rodríguez, S.A., Rivas-Morales, C., Leos-Rivas, C., et al. (2025) Green Extraction of Orange Peel Using Deep Eutectic Solvents Assisted by Ultrasound: Bioactivity Assessment and Compound Quantification. Clean Technologies , 7, Article 112. https://doi.org/10.3390/cleantechnol7040112
Cao, J. and Su, E. (2021) Hydrophobic Deep Eutectic Solvents: The New Generation of Green Solvents for Diversified and Colorful Applications in Green Chemistry. Journal of Cleaner Production , 314, Article ID: 127965. https://doi.org/10.1016/j.jclepro.2021.127965
Sportiello, L., Favati, F., Condelli, N., Di Cairano, M., Caruso, M.C., Simonato, B., et al. (2023) Hydrophobic Deep Eutectic Solvents in the Food Sector: Focus on Their Use for the Extraction of Bioactive Compounds. Food Chemistry , 405, Article ID: 134703. https://doi.org/10.1016/j.foodchem.2022.134703
Viñas-Ospino, A., Panić, M., Radojčić-Redovniković, I., Blesa, J. and Esteve, M.J. (2023) Using Novel Hydrophobic Deep Eutectic Solvents to Improve a Sustainable Carotenoid Extraction from Orange Peels. Food Bioscience , 53, Article ID: 102570. https://doi.org/10.1016/j.fbio.2023.102570
Viñas-Ospino, A., Sá-Nogueira, I., Duarte, A.R., López-Malo, D., Esteve, M.J., Frígola, A., et al. (2024) Exploring the Biological Properties and Bioaccessibility of Orange Peel Extracts Using Deep Eutectic Systems. Food Bioscience , 61, Article ID: 104684. https://doi.org/10.1016/j.fbio.2024.104684
Bhandari, D.P., Poudel, D.K., Satyal, P., Khadayat, K., Dhami, S., Aryal, D., et al . (2021) Volatile Compounds and Antioxidant and Antimicrobial Activities of Selected Citrus Essential Oils Originated from Nepal. Molecules , 26, Article 6683. https://doi.org/10.3390/molecules26216683
Liu, Y., Benohoud, M., Galani Yamdeu, J.H., Gong, Y.Y. and Orfila, C. (2021) Green Extraction of Polyphenols from Citrus Peel By-Products and Their Antifungal Activity against Aspergillus flavus . Food Chemistry : X , 12, Article ID: 100144. https://doi.org/10.1016/j.fochx.2021.100144
Gałuszka, A., Migaszewski, Z. and Namieśnik, J. (2013) The 12 Principles of Green Analytical Chemistry and the SIGNIFICANCE Mnemonic of Green Analytical Practices. TrAC Trends in Analytical Chemistry , 50, 78-84. https://doi.org/10.1016/j.trac.2013.04.010
Domínguez-Rodríguez, G., Amador-Luna, V.M., Castro-Puyana, M., Ibáñez, E. and Marina, M.L. (2025) Sustainable Strategies to Obtain Bioactive Compounds from Citrus Peels by Supercritical Fluid Extraction, Ultrasound-Assisted Extraction, and Natural Deep Eutectic Solvents. Food Research International , 202, Article ID: 115713. https://doi.org/10.1016/j.foodres.2025.115713
de Miera, B.S., Cañadas, R., González-Miquel, M. and González, E.J. (2023) Recovery of Phenolic Compounds from Orange Peel Waste by Conventional and Assisted Extraction Techniques Using Sustainable Solvents. Frontiers in Bioscience-Elite , 15, Article 30. https://doi.org/10.31083/j.fbe1504030
Multari, S., Licciardello, C., Caruso, M., Anesi, A. and Martens, S. (2021) Flavedo and Albedo of Five Citrus Fruits from Southern Italy: Physicochemical Characteristics and Enzyme-Assisted Extraction of Phenolic Compounds. Journal of Food Measurement and Characterization , 15, 1754-1762. https://doi.org/10.1007/s11694-020-00787-5
Fu, X., Wang, D., Belwal, T., Xu, Y., Li, L. and Luo, Z. (2021) Sonication-Synergistic Natural Deep Eutectic Solvent as a Green and Efficient Approach for Extraction of Phenolic Compounds from Peels of Carya cathayensis Sarg. Food Chemistry , 355, Article ID: 129577. https://doi.org/10.1016/j.foodchem.2021.129577
Ghadiri, K., Raofie, F., Qomi, M. and Davoodi, A. (2021) Response Surface Methodology for Optimization of Supercritical Fluid Extraction of Orange Peel Essential Oil. Pharmaceutical and Biomedical Research , 6, 303-312. https://doi.org/10.18502/pbr.v6i4.5117
Wei, J., Tao, B., Ye, Z., Li, Y. and Zhou, Z. (2025) Ultrasound-assisted Extraction of Carotenoids from Citrus Peel by Olive Oil and Its Application in Functional Emulsions. Ultrasonics Sonochemistry , 122, Article ID: 107629. https://doi.org/10.1016/j.ultsonch.2025.107629
Alonso-Vázquez, P., Isola, A., Sánchez-Arévalo, C.M., Cuartas-Uribe, B., Vincent-Vela, M.C. and Álvarez-Blanco, S. (2025) Concentration of Phenolic Compounds from an Orange Peel Waste Extract Using a Combination of Ultrafiltration and Forward Osmosis. Separation and Purification Technology , 360, Article ID: 131228. https://doi.org/10.1016/j.seppur.2024.131228
Lai, C., Huang, M., Xiong, Q., Liang, Y., Jiang, Y. and Zhang, J. (2024) Green and Efficient Approach to Extract Bioactive Flavonoids with Antioxidant, Antibacterial, Antiglycation, and Enzyme Inhibitory Activities from Navel Orange Peel. Sustainable Chemistry and Pharmacy , 38, Article ID: 101479. https://doi.org/10.1016/j.scp.2024.101479
He, Y. and Chen, W. (2023) Evaluation of Sustainable Development Policy of Sichuan Citrus Industry in China Based on Dea-Malmquist Index and DID Model. Sustainability , 15, Article 4260. https://doi.org/10.3390/su15054260
Kalompatsios, D., Athanasiadis, V., Palaiogiannis, D., Lalas, S.I. and Makris, D.P. (2022) Valorization of Waste Orange Peels: Aqueous Antioxidant Polyphenol Extraction as Affected by Organic Acid Addition. Beverages , 8, Article 71. https://doi.org/10.3390/beverages8040071
ISTAT (2023) Il clima continua a penalizzare l’agricoltura. https://www.istat.it/wp-content/uploads/2024/06/REPORT_ANDAMENTO_ECONOMIA_AGRICOLA_2024-1.pdf
Forner-Giner, M.Á., Ballesta-de los Santos, M., Melgarejo, P., Martínez-Nicolás, J.J., Melián-Navarro, A., Ruíz-Canales, A., et al . (2023) Fruit Quality and Primary and Secondary Metabolites Content in Eight Varieties of Blood Oranges. Agronomy , 13, Article 1037. https://doi.org/10.3390/agronomy13041037
Özcan, M.M., Ghafoor, K., Al Juhaimi, F., Uslu, N., Babiker, E.E., Mohamed Ahmed, I.A., et al . (2020) Influence of Drying Techniques on Bioactive Properties, Phenolic Compounds and Fatty Acid Compositions of Dried Lemon and Orange Peel Powders. Journal of Food Science and Technology , 58, 147-158. https://doi.org/10.1007/s13197-020-04524-0
Singh, B., Singh, J.P., Kaur, A. and Yadav, M.P. (2021) Insights into the Chemical Composition and Bioactivities of Citrus Peel Essential Oils. Food Research International , 143, Article ID: 110231. https://doi.org/10.1016/j.foodres.2021.110231
Penumala, M., Zinka, R.B., Shaik, J.B. and Amooru Gangaiah, D. (2017) In Vitro Screening of Three Indian Medicinal Plants for Their Phytochemicals, Anticholinesterase, Antiglucosidase, Antioxidant, and Neuroprotective Effects. BioMed Research International , 2017, Article ID: 5140506. https://doi.org/10.1155/2017/5140506
Bratovcic, A., Djapo-Lavic, M., Kazazic, M. and Mehic, E. (2021). Evaluation of Anti-Oxidant Capacities of Orange, Lemon, Apple, and Banana Peel Extracts by FRAP and ABTS Methods. Revue Roumaine de Chimie , 66, 713-717.
Grand View Research (2022) Gluten-Free Products Market Size Report, 2022-2030. Gluten-Free Products Market Size, Share & Trends Analysis Report by Product (Bakery Products, Dairy/Dairy Alternatives), by Distribution Channel (Supermarkets & Hypermarkets, Convenience Stores), by Region, and Segment Forecasts. https://www.grandviewresearch.com/industry-analysis/gluten-free-products-market
Gasparre, N., Garzon, R., Marín, K. and Rosell, C.M. (2024) Exploring the Integration of Orange Peel for Sustainable Gluten-Free Flatbread Making. LWT , 198, Article ID: 115969. https://doi.org/10.1016/j.lwt.2024.115969
Klop, B., Elte, J. and Cabezas, M. (2013) Dyslipidemia in Obesity: Mechanisms and Potential Targets. Nutrients , 5, 1218-1240. https://doi.org/10.3390/nu5041218
Botta-Arias, V.L., Ramos-Escudero, F., Muñoz, A.M. and Anticona, M. (2024) Nutritional Composition, Phenolic Compounds, and Sensory Evaluation of Osmosonicated Orange Peel Snacks Impregnated with Plant Extracts. Applied Food Research , 4, Article ID: 100486. https://doi.org/10.1016/j.afres.2024.100486
Ademosun, A.O. (2024) Enrichment with Citrus Peels as a Strategy for Improving the Health Benefits and Nutritional Value of Breakfast Cereals: A Review. Human Nutrition & Metabolism , 36, Article ID: 200239. https://doi.org/10.1016/j.hnm.2024.200239
Parhiz, H., Roohbakhsh, A., Soltani, F., Rezaee, R. and Iranshahi, M. (2014) Antioxidant and Anti-Inflammatory Properties of the Citrus Flavonoids Hesperidin and Hesperetin: An Updated Review of Their Molecular Mechanisms and Experimental Models. Phytotherapy Research , 29, 323-331. https://doi.org/10.1002/ptr.5256
Ahmed, S.A., Taie, H.A.A. and Abdel Wahab, W.A. (2023) Antioxidant Capacity and Antitumor Activity of the Bioactive Protein Prepared from Orange Peel Residues as a By-Product Using Fungal Protease. International Journal of Biological Macromolecules , 234, Article ID: 123578. https://doi.org/10.1016/j.ijbiomac.2023.123578
Mohammed, D.M., Maan, S.A., Abou Baker, D.H. and Abozed, S.S. (2024) In Vitro Assessments of Antioxidant, Antimicrobial, Cytotoxicity and Anti-Inflammatory Characteristics of Flavonoid Fractions from Flavedo and Albedo Orange Peel as Novel Food Additives. Food Bioscience , 62, Article ID: 105581. https://doi.org/10.1016/j.fbio.2024.105581
Yuan, Y., Zhou, J., Zhang, N., Xing, X., Zhao, L. and Zhou, F. (2023) In Vivo Study of Orange Peel Fermentation and Improvement of Androgen Overproduction Causing Acne. Food Bioscience , 56, Article ID: 103124. https://doi.org/10.1016/j.fbio.2023.103124
Ademosun, A.O., Ajeigbe, O.F., Ademosun, M.T., Ogunruku, O.O. and Oboh, G. (2025) Improving Gut Microbiome through Diet Rich in Dietary Fibre and Polyphenols: The Case for Orange Peels. Human Nutrition & Metabolism , 39, Article ID: 200295. https://doi.org/10.1016/j.hnm.2024.200295
Dixit, S.S., Muruganandam, L. and Ganesh Moorthy, I. (2025) Pectin from Fruit Peel: A Comprehensive Review on Various Extraction Approaches and Their Potential Applications in Pharmaceutical and Food Industries. Carbohydrate Polymer Technologies and Applications , 9, Article ID: 100708. https://doi.org/10.1016/j.carpta.2025.100708
Bratovcic, A. (2022) Bio-and Synthetic Nanocomposites for Food Packaging. In: Ameta, S.C. and Ameta, R., Eds., The Science of Nanomaterials , Apple Academic Press, 303-334. https://doi.org/10.1201/9781003283126-11
Pagliarini, E., Minichiello, C., Sisti, L., Totaro, G., Baffoni, L., Di Gioia, D., et al . (2024) From Food Waste to Eco-Friendly Functionalized Polymer Composites: Investigation of Orange Peels as Active Filler. New Biotechnology , 80, 37-45. https://doi.org/10.1016/j.nbt.2024.01.001
Revathi, V., Bora, S., Afzia, N. and Ghosh, T. (2025) Orange Peel Composition, Biopolymer Extraction, and Applications in Paper and Packaging Sector: A Review. Sustainable Chemistry and Pharmacy , 43, Article ID: 101908. https://doi.org/10.1016/j.scp.2025.101908
Gouda, M., Abd El-Lateef, H.M., Abou Taleb, M.F., Abdelaziz, M.A. and Khalaf, M.M. (2025) Insight into the Physicochemical Characterization of Composite Orange Peel Fabricated Packaging Film: Fighting Foodborne Pathogens and Oxidative Stress. International Journal of Biological Macromolecules , 306, Article ID: 141777. https://doi.org/10.1016/j.ijbiomac.2025.141777
Iffath, R., Ara, R., Ahmed, T. and Biswas, A. (2025) Fabrication and Characterization of Waste Eggshell Microparticles Reinforced Biodegradable Composite Packaging Films Enriched with Pectin and Orange Peel Essential Oil. Applied Food Research , 5, Article ID: 100735. https://doi.org/10.1016/j.afres.2025.100735
Mia, M.S., Ara, R., Rahman, O., Shaha, L.C., Galib, R.M. and Alam, M. (2025) Valorization of Fruit Peel Extracts as Natural Preservatives: Characterization and Efficacy in Preserving Chicken Meatballs. Applied Food Research , 5, Article ID: 100981. https://doi.org/10.1016/j.afres.2025.100981
Maldonado, J.A.H., Aguilera, C.E.C., Hernández, M.M.S., Arias, A.N.A. and Soto, R.H. (2021) Evaluation of Orange Peel ( Citrus sinensis ) as a Source of Bioactive Components and Its Use as a Bioadsorbent. Desalination and Water Treatment , 231, 348-358. https://doi.org/10.5004/dwt.2021.27499
Gebreabe, S.T., Worku, A., Gnaro, M.A., Kassahun, E., Ale, T.H., Sime, T., et al . (2025) Response Surface Optimization of Turbidity Removal from Highly Turbid Surface Water Using Orange Peel Powder as a Sustainable Coagulant. Next Research , 2, Article ID: 101058. https://doi.org/10.1016/j.nexres.2025.101058