Preparation of Ionic Liquid Functionalized Silica Nanoparticles for Oral Drug Delivery
- 1 Department of Chemistry, Azarbaijan Shahid Madani University, Tabriz, Iran
- 2 Department of Chemistry, Azarbaijan Shahid Madani University, Tabriz, Iran.
- 3 Department of Chemistry, Azarbaijan Shahid Madani University, Tabriz, Iran
Abstract
The objective of this study is to utilize the pH sensitivity of modified silica nanoparticles (SNIL) by imidazole-based ionic liquid for oral delivery of insulin. In the first time, the imidazole was covalently attached to the 3-trimethoxysily-lpropyl chloride with replacement of all the chlorine atoms. Then, a silica nanoparticle was modified by N-(3-trimeth-oxysilylpropyl) imidazole. The nanocapsule (NCIL) was achieved after the etching of the modified silica nanoparticle template with hydrofluoric acid. The nanoparticles connected through an ionic liquid-like network were characterized by FTIR and SEM. Insulin was entrapped in these carriers and the in vitro release profiles were established separately in both enzyme-free simulated gastric and intestinal fluids (SGF, pH 1) and (SIF, pH 7.4), respectively. When these drug-loaded nanoparticles was placed in physiological buffer solution (pH 7.4), a partial negative surface charge on the modified silica nanoparticle was generated due to the deprotonation of silanol groups, and the strong electrostatic repulsion triggered a sustained release of the loaded molecules.
- V. H. L. Lee and A. Yamamoto, “Penetration and Enzymatic Barriers to Peptide and Protein Absorption,” Advanced Drug Delivery Reviews, Vol. 4, No. 2, 1990, pp. 171-207. doi:10.1016/0169-409X(89)90018-5
- J. F. Woodley, “Enzymatic Barriers for GI Peptide and Protein Delivery,” Critical Reviews in Therapeutic Drug Carrier Systems, Vol. 11, 1994, pp. 61-95.
- J. S. Beck, M. E. Leonowicz and W. J. Roth, “Ordered Mesoporous Mole-cular-Sieves Synthesized by a Liquid- Crystal Template Mechanism,” Nature, Vol. 359, 1992, pp. 710-712. doi:10.1038/359710a0
- D. E. De Vos, M. Dams and B. F. Sels, “Dielectric Properties of BNT Ferroelectrics in Paraelectric Phase,” Chemical Reviews, Vol. 102, 2002, pp. 3615-3640. doi:10.1021/cr010368u
- A. Vinu, M. Miyahara and K. Z. Hossain, “Lysozyme Adsorption onto Mesoporous Materials: Effect of Pore Geometry and Stability of Ad-sorbents,” Journal of Nanoscience and Nanotechnology, Vol. 7, No. 3, 2007, pp. 828-832. doi:10.1166/jnn.2007.511
- J. Salonen, L. Laitinen and A. M. Kaukonen, “Mesoporous Silicon Microparticles for Oral Drug Delivery: Loading and Release of Five Model Drugs,” Journal of Controlled Release, Vol. 108, No. 2-3, 2005, pp. 362-374. doi:10.1016/j.jconrel.2005.08.017
- I. I. Slowing, B. G. Trewyn and S. Giri, “Mesoporous Silica Nanoparticles for Drug Delivery and Biosensing Applications,” Advanced Functional Materials, Vol. 17, No. 8, 2007, pp. 1225-1236. doi:10.1002/adfm.200601191
- J. Lu, M. Liong and J. I. Zink, “Mesoporous Silica Nanoparticles as a Delivery System for Hydrophobic Anticancer Drugs,” Small, Vol. 3, No. 8, 2007, pp. 1341- 1346. doi:10.1002/smll.200700005
- J. Gu, W. Fan and A. Shimojima, “Organic-Inorganic Mesoporous Nanocarriers, Integrated with Biogenic Li-gands,” Small, Vol. 3, No. 10, 2007, pp. 1740-1744. doi:10.1002/smll.200700311
- A. Vinu, K. Z. Hossain and K. Ariga, “Recent Advances in Functionalization of Mesoporous Silica,” Journal of Nanoscience and Nanotechnology, Vol. 5, No. 3, 2005, pp. 347-371. doi:10.1166/jnn.2005.089
- F. Y. Qu, G. S. Zhu and S. Y. Huang, “Effective Controlled Release of Captopril by Silylation of Mesoporous MCM-41,” Physical Chemistry Chemical Physics, Vol. 7, No. 2, 2006, pp. 400-406. doi:10.1002/cphc.200500294
- P. Horcajada, A. Ra-mila and J. Perez-Pariente, “Influence of Pore Size of MCM-41 Matrices on Drug Delivery Rate,” Microporous and Mesoporous Mater, Vol. 68, No. 1-3, 2004, pp. 105-109. doi:10.1016/j.micromeso.2003.12.012