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Biodegradable Chitosan/Multiwalled Carbon Nanotube Composite for Bone Tissue Engineering
Institute of Engineering and Technology, Autonommous University of Juarez City, Ciudad Juarez, México
Instituto of Design and Art, Autonommous University of Juarez City, Ciudad Juarez, México
Advanced Materials Research Center, CIMAV, Chihuahua, México
Institute of Biomedical Sciences, Autonommous University of Juarez City, Ciudad Juarez, México
Institute of Engineering and Technology, Autonommous University of Juarez City, Ciudad Juarez, México
Institute of Engineering and Technology, Autonommous University of Juarez City, Ciudad Juarez, México
- 1 Institute of Engineering and Technology, Autonommous University of Juarez City, Ciudad Juarez, México
- 2 Instituto of Design and Art, Autonommous University of Juarez City, Ciudad Juarez, México
- 3 Advanced Materials Research Center, CIMAV, Chihuahua, México
- 4 Institute of Biomedical Sciences, Autonommous University of Juarez City, Ciudad Juarez, México
- 5 Institute of Engineering and Technology, Autonommous University of Juarez City, Ciudad Juarez, México
- 6 Institute of Engineering and Technology, Autonommous University of Juarez City, Ciudad Juarez, México
Journal of Biomaterials and Nanobiotechnology·Volume 04 (2013)·Pages 204–211·Published 11 April 2013·DOI10.4236/jbnb.2013.42025
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Abstract
In this work the influence of multiwalled carbon nanotubes (MWCNT) on mechanical properties was evaluated also the osteoinduction mechanism in Chitosan/MWCNT composite is reported. The morphology and the mechanical properties of the scaffolds were controlled by varying solvent ratios, quenching temperatures and carbon nanotubes concentration. In vitro cell culture of Sprague-Dawley rat’s osteoblasts was used to evaluate the phenotype expression of cells in the scaffolds. The presence of MWCNT in a chitosan matrix improving its mechanical properties and sustain osteoblast growth and differentiation that represent a potential application of the Chitosan/MWCNT as biomaterial for bone tissue engineering.
KeywordsBone Tissue RegenerationChitosanMultiwalled Carbon NanotubesComposite
- J. Venkatesam, Z. Qian, B. Ryu, N. Ashok and S. Kim, “Preparation and Characterization of Chitosan-Carbon Nanotube Scaffolds for Bone Tissue Engineering,” International Journal of Biological Macromolecules, Vol. 50, No. 2, 2012, pp. 393-402. doi:10.1016/j.ijbiomac.2011.12.032
- L. P. Pan, X. Pei, R. He, Q. Wan and J. Wang, “Multiwall Carbon Nanotubes/Polycaprolactone Composites for Bone Tissue Engineering Application,” Colloids and Surfaces B: Biointerfaces, Vol. 93, No. 5, 2012, pp. 226-234. doi:10.1016/j.colsurfb.2012.01.011
- M. D. Raucci, V. D’Antò and V. Guarino, “Biomineralized Porous Composite Scaffolds Prepared by Chemical Synthesis for Bone Tissue Regeneration,” Acta Biomaterialia, Vol. 6, No. 4, 2010, pp. 4090-4099. doi:10.1016/j.actbio.2010.04.018
- M. V. Mattioli-Belmonte, V. Giovanni and W. Yudan, “Tuning Polycaprolactone-Carbon Nanotube Composites for Bone Tissue Engineering Scaffolds,” Materials Science and Engineering C, Vol. 32, No. 2, 2012, pp. 152159. doi:10.1016/j.msec.2011.10.010
- X. Lu, T. Qiu, X. Wang and F. Zhang, “Preparation of Foam-Like Carbon Nanotubes/Hydroxyapatite Composite Scaffolds with Superparamagnetic Properties,” Applied Surface Science, Vol. 262, No. 1, 2012, pp. 227-230. doi:10.1016/j.apsusc.2012.06.041
- M. N. Elsabee, “Chitosan Based Nanofibers, Review,” Materials Science and Engineering C, Vol. 32, No. 7, 2012, pp. 1711-1726. doi:10.1016/j.msec.2012.05.009
- J. C. Yang and C. Hsien, “Preparation and Characterization of Polyvibyl Alcohol/Chitosan Blended Membrane for Alkaline Direct Methanol Fuel Cells,” Journal of Membrane Science, Vol. 419-420, No. 7, 2012, pp. 65-71. doi:10.1016/j.memsci.2012.06.051
- S. R. Kanatt, M. S. Rao, S. P. Chawla and A. Sharma, “Active Chitosan-Polyvinyl Alcohol Films with Natural Extracts,” Food Hydrocolloids, Vol. 29, 2012, pp. 290287.
- D. B. Baskar, R. Balu and T. S. Kumar, “Mineralization of Pristine Chitosan Film through Biomimetic Process,” International Journal of Biological Macromolecules, Vol. 49, No. 3, 2011, pp. 385-389.
- O. D. Yilmaz, D. O. Demirkol, S. Gülcemal, A. Kilinc, S. Timur and B. Cetinkauya, “Chitosan-Ferrocene Film as a Platform for Flow Injection Analysis Applications of Glucose Oxidase and Gluconobacter Oxydans Biosensors,” Colloids and Surfaces B: Biointerfaces, Vol. 100, No. 2, 2012, pp. 62-68. doi:10.1016/j.colsurfb.2012.05.020
- M. R. Tuhin, O. T. Mohammad, R. Nazia, M. E. Haque, R. A. Khan, N. C. Dafader, R. Islam and M. Nurnabi, “Modification of Mechanical and Thermal Property of Chitosan-Starch Blend Films,” Radiation Physics and Chemistry, Vol. 81, No. 10, 2012, pp. 1659-1668. doi:10.1016/j.radphyschem.2012.04.015