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Pectin-Based Biodegradable Hydrogels with Potential Biomedical Applications as Drug Delivery Systems
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Journal of Biomaterials and Nanobiotechnology·Volume 02 (2011)·Pages 36–40·Published 27 January 2011·DOI10.4236/jbnb.2011.21005
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Abstract
In this work, synthesis and swelling behavior of a superabsorbent hydrogel based on Pectin (Pc) and polyacrylonitrile (PAN) were investigated. A mechanism for hydrogel formation was proposed and the structure of the product was es-tablished using FTIR spectroscopy. The Pc-poly (sodium acrylate-co-acrylamide) hydrogel exhibited a pH-responsive swelling-deswelling behavior at pH’s 2 and 8. This on-off switching behavior provides the hydrogel with the potential to control delivery of bioactive agents. Release profiles of ibuprofen (IBU), a poor water-soluble drug, from the hydro-gels were studied under both simulated gastric and intestinal pH conditions.
KeywordsPectinPolyacrylonitrileHydrogelIbuprofenDrug Delivery
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