Poly(Vinyl Alcohol)/Collagen/Hydroxyapatite Nanoparticles Hybrid System Containing Yttrium-90 as a Potential Agent to Treat Osteosarcoma — Oak Academic Publishing
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Poly(Vinyl Alcohol)/Collagen/Hydroxyapatite Nanoparticles Hybrid System Containing Yttrium-90 as a Potential Agent to Treat Osteosarcoma
Servi?o de Nanotecnologia e Materiais Nucleares, Centro de Desenvolvimento da Tecnologia Nuclear/Comiss?o Nacional de Energia Nuclear (CDTN/CNEN), Belo Horizonte, Brasil
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Servi?o de Nanotecnologia e Materiais Nucleares, Centro de Desenvolvimento da Tecnologia Nuclear/Comiss?o Nacional de Energia Nuclear (CDTN/CNEN), Belo Horizonte, Brasil
1 Servi?o de Nanotecnologia e Materiais Nucleares, Centro de Desenvolvimento da Tecnologia Nuclear/Comiss?o Nacional de Energia Nuclear (CDTN/CNEN), Belo Horizonte, Brasil
2 Servi?o de Nanotecnologia e Materiais Nucleares, Centro de Desenvolvimento da Tecnologia Nuclear/Comiss?o Nacional de Energia Nuclear (CDTN/CNEN), Belo Horizonte, Brasil
Osteosarcoma is the most common primary malignant bone tumors, affecting mostly children, adolescents and young adults. This is an aggressive tumor that results in a high mortality rate and poor prognosis. Due to the low sensitivity of osteosarcoma to ionizing radiation, such treatment is not used very often and it can be recom mended only to postsurgical therapy. As an alternative therapy, functionalized nanomaterials allow their accu mulation in tumor tissues due to their unique properties, making them good agents to act as stable carriers for radionuclides. In this work, mesoporous hydroxyapatite nanoparticles were synthesized and the functionaliza tion process with poly(vinyl alcohol) and collagen was investigated. The samples were characterized by X-ray diffraction (XR D), N 2 adsorption, elemental analysis (CHN), Fourier Transform Infrared Spectroscopy (FTIR), Ni trogen Adsorption, Transmission Electron Microscopy (TEM), and Thermal Analysis. Also, the yttrium incorpora tion potential and its release kinetics in the hydroxyapatite matrix were evaluated to study the capacity of this system to treat osteosarcomas. The results indicate that this material has a promisor potential to treat this kind of tumor.
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