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Nano-Coupling of Cephalosporin Antibiotics with Fe<SUB>3</SUB>O<SUB>4</SUB> Nanoparticles: Trojan Horse Approach in Antimicrobial Chemotherapy of Infections Caused by <i>Klebsiella spp</i>.
Baku State University, Nano Research Laboratory, Baku, Azerbaijan
Baku State University, Nano Research Laboratory, Baku, Azerbaijan
Baku State University, Nano Research Laboratory, Baku, Azerbaijan
Baku State University, Nano Research Laboratory, Baku, Azerbaijan
Baku State University, Nano Research Laboratory, Baku, Azerbaijan
Baku State University, Nano Research Laboratory, Baku, Azerbaijan
Baku State University, Nano Research Laboratory, Baku, Azerbaijan
Baku State University, Nano Research Laboratory, Baku, Azerbaijan
Baku State University, Nano Research Laboratory, Baku, Azerbaijan
- 1 Baku State University, Nano Research Laboratory, Baku, Azerbaijan
- 2 Baku State University, Nano Research Laboratory, Baku, Azerbaijan
- 3 Baku State University, Nano Research Laboratory, Baku, Azerbaijan
- 4 Baku State University, Nano Research Laboratory, Baku, Azerbaijan
- 5 Baku State University, Nano Research Laboratory, Baku, Azerbaijan
- 6 Baku State University, Nano Research Laboratory, Baku, Azerbaijan
- 7 Baku State University, Nano Research Laboratory, Baku, Azerbaijan
- 8 Baku State University, Nano Research Laboratory, Baku, Azerbaijan
- 9 Baku State University, Nano Research Laboratory, Baku, Azerbaijan
Journal of Biomaterials and Nanobiotechnology·Volume 06 (2015)·Pages 225–235·Published 27 May 2015·DOI10.4236/jbnb.2015.63021
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Abstract
In the present study we had an aim to develop the methods of functionalizing the surface of magnetite nanoparticles with cefotaxime and ceftriaxone antibiotics. The quantitative analysis of the nanostructured cephalosporins was determined by Atom Absorbance Spectroscopy (AAS) and based on the Lambert-Beer law. The engineered nanostructures were tested on gram-negative microorganisms Klebsiella spp., of Enterobacteriaceae, and gram-positive bacteria Staphylococcus aureus , each having multi-drug resistance properties.
KeywordsMagnetite NanoparticlesCephalosporinCefotaximeCeftriaxone Klebsiella<i>Staphylococcus aureus</i>
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