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Synthesis and Characterization of Fe<sub>3</sub>O<sub>4</sub> Coated on APTES as Carriers for Morin-Anticancer Drug
School of Chemistry and Chemical Engineering, Shanxi University, Taiyuan, China
School of Chemistry and Chemical Engineering, Shanxi University, Taiyuan, China
Research Center of Environmental Science and Engineering, Shanxi University, Taiyuan, China
School of Chemistry and Chemical Engineering, Shanxi University, Taiyuan, China
- 1 School of Chemistry and Chemical Engineering, Shanxi University, Taiyuan, China
- 2 School of Chemistry and Chemical Engineering, Shanxi University, Taiyuan, China
- 3 Research Center of Environmental Science and Engineering, Shanxi University, Taiyuan, China
- 4 School of Chemistry and Chemical Engineering, Shanxi University, Taiyuan, China
Journal of Biomaterials and Nanobiotechnology·Volume 06 (2015)·Pages 267–275·Published 16 September 2015·DOI10.4236/jbnb.2015.64025
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Abstract
Morin (MR) is an anticancer drug present in fruits and Chinese herbs. Fe 3 O 4 magnetic nanoparticles (MNPs) coated on 3-aminopropyl triethoxysilane (APTES) were synthesized (MNPs-APTES) as carriers for MR. The characterization of drug delivery system was confirmed by Fourier Transform Infrared (FTIR), Transmission Electron Microscope (TEM), X-Ray Diffraction (XRD), dynamic light scattering (DLS), and vibrating sample magnetometer (VSM). The adsorbed APTES on the magnetite surface (MNPs-APTES) was examined by FTIR. The TEM image showed that the average particle size is obtained to be about 26.7 nm for MNPs-APTES. The MR loading and release behavior of MNPs-APTES were studied and the results showed that up to 60% of the adsorbed drug was released within 4 h. In summary, the MNPs-APTES nanocarriers are based on the results, promising for targeted morin drug delivery.
KeywordsMagnetic NanoparticlesDrug DeliveryFlavonoidMorin
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