Surface Modification of PEEK and Its Osteoconductivity and Anti-Inflammatory Properties
- 1 Institute of Materials and Systems for Sustainability, Nagoya University, Nagoya, Japan
- 2 Department of Materials Science and Engineering, Graduate School of Engineering, Nagoya University, Nagoya, Japan
- 3 Liaison Center for Innovative Dentistry, Graduate School of Dentistry, Tohoku University, Sendai, Japan
- 4 Institute of Materials and Systems for Sustainability, Nagoya University, Nagoya, Japan
Abstract
Polyetheretherketone (PEEK) is known as one of the “super-engineering plastics” and is used as an intervertebral disk spacer in the body. PEEK has a hydrophobic surface (water contact angle (WCA) > 80 ° ) and high chemical resistance, and it is thus difficult to perform any surface treatment, such as hydrophilization. In this study, we aimed to form a hydrophilic surface on PEEK without coating layers by using hydroprocessing (aqueous solution processing), and we examined the osteoconductivity and anti-inflammatory properties of surface-treated PEEK in vi vo compared with Ti implants. The WCA value of PEEK reached ~ 20 ° using a combination of immersion in a solution of >16.2 M H 2 SO 4 and ultraviolet irradiation (172 nm). In in vivo testing, the hydrophilization of PEEK by surface modification without a coating layer improved the osteoconductivity and anti-inflammatory properties. The relationship between the bone-implant contact ratio and the WCA values of the surface-modified PEEK agreed well with that of the surface-treated Ti.
- Buser, D., Broggini, N., Wieland, M., Schenk, R.K., Denzer, A.J., Cochran, D.L., Hoffmann, B., Lussi, A. and Steinemann, S.G. (2004) Enhanced Bone Apposition to a Chemically Modified SLA Titanium Surface. Journal of Dental Research, 83, 529-533. https://doi.org/10.1177/154405910408300704
- Cochran, D.L., Buser, D., ten Bruggenkate, C.M., Weingart, D., Taylor, T.M., Bernald, J.P., Peters, F. and Simpson, J.P. (2002) The Use of Reduced Healing Times on ITI ® Implants with a Sandblasted and Acid-Etched (SLA) Surface: Early Results from Clinical Trials on ITI ® SLA Implants. Clinical Oral Implants Research, 13, 144-153. https://doi.org/10.1034/j.1600-0501.2002.130204.x
- Eriksson, C., Nygren, H. and Ohlson, K. (2004) Implantation of Hydrophilic and Hydrophobic Titanium Discs in Rat Tibia: Cellular Reactions on the Surfaces during the First 3 Weeks in Bone. Biomater, 25, 4759-4766. https://doi.org/10.1016/j.biomaterials.2003.12.006
- Park, J.-W., Park, K.-B. and Suh, J.-Y. (2007) Effects of Calcium Ion Incorporation on Bone Healing of Ti6Al4V Alloy Implants in Rabbit Tibiae. Biomater, 28, 3306-3313. https://doi.org/10.1016/j.biomaterials.2007.04.007
- Zuldesmi, M., Waki, A., Kuroda, K. and Okido, M. (2013) High Osteoconductive Surface of Pure Titanium by Hydrothermal Treatment. Journal of Biomaterials and Nanobiotechnology, 4, 284-290. https://doi.org/10.4236/jbnb.2013.43036
- Toth, J.M., Wang, M., Estes, B.T., Scifert, J.L., Seim, H.B. and Turmer, A.S. (2006) Polyetheretherketone as a Biomaterial for Spinal Applications. Biomater, 27, 324-334. https://doi.org/10.1016/j.biomaterials.2005.07.011
- Suzuki, N., Umeda, T., Sumi, T., Horikoshi, S., Kuwahara, H., Toyama, T., Musha, Y. and Itatani, K. (2016) Rapid Formation of Hydroxyapatite Layer on Polyetheretherketone by Vacuum Ultraviolet Irradiation and Microwave Heating Techniques. Journal of the Ceramic Society of Japan, 124, 49-54. https://doi.org/10.2109/jcersj2.15209
- Chvatalova, L., Cermak, R., Mracek, A., Grulich, O., Vesel, A., Ponizil, P., Minarik, A., Cvelbar, U., Benicek, L. and Sajdl, P. (2012) The Effect of Plasma Treatment on Structure and Properties of Poly(1-butene) Surface. European Polymer Journal, 48, 866-874. https://doi.org/10.1016/j.eurpolymj.2012.02.007
- Caffesse, R.G., Nasjleti, C.E., Morrison, E.C. and Sanchez, R. (1994) Guided Tissue Regeneration: Comparison of Bioabsorbable and Non-Bioabsorbable Membranes. Histologic and Histometric Study in Dogs. Journal of Periodontology, 65, 583-591. https://doi.org/10.1902/jop.1994.65.6.583