A New Liposomal-Drug-in-Adhesive Patch for Transdermal Delivery of Sodium Diclofenac
- 1
- 2
Abstract
Liposomes are known to have considerable potential as drug carriers such as liposomal suspension, freeze dried and cream-based systems among many other liposomal formulations. In this study a new drug-in-adhesive patch was fabricated using liposome-based nanocarrier. Transfersomes as ultra-deformable liposomes are based on phosphatidylcholin 95% (phospholipon 90G) and phosphatidylcholin 50% (phosal 50PG) were prepared and further optimized in a final acrylic patch system for effective adhesion. The prepared liposomes were added to an acrylic adhesive to obtain a new hybrid transdermal patch termed as “lipo-drug-in-adhesive” patch system. The sodium diclofenac was selected as a model drug and the permeation of the drug across rat skin was evaluated (P > 0.05), using the lipo-drug-in-adhesive patch system with various percentages of transfersomes (4% - 8%w/w) and constant concentration of the drug (2% w/w). The peel strength and tack value of samples were also examined and quantified. The maximum flux of sodium diclofenac was observed in samples containing 8% (w/w) phosphatidylcholin 50%. The peel strength and tack value in samples containing phosphatidylcholin 50% were lower than those samples containing phosphatidylcholin 95%. It was observed that with increased amount of liposome in drug-in-adhesive patch system, the rate of skin permeation of the drug was also increased. It can be concluded that the developed lipo-drug-in-adhesive patch system enhances the drug release potential of transdermal delivering systems.
- K. B. Ita, J. D. Preez, M. E. Lane, et al., “Dermal Delivery of Selected Hydrophilic Drugs from Elastic Liposomes: Effect of phospholipid Formulation and Surfactants,” Journal of Pharmacy and Pharmacology, Vol. 59, No. 9, 2007, pp. 1215-1222. doi:10.1211/jpp.59.9.0005
- M. Manconi, S. Mura, C. Sinico, et al., “Development and Characterization of Liposomes Containing Glycols as Carriers for Diclofenac,” Colloids and Surfaces A: Physicochemical and Engineering Aspects, Vol. 342, No. 1-3, 2009, pp. 53-58. doi:10.1016/j.colsurfa.2009.04.006
- L. B. Lopes, M. V. Scarpa and G. V. J. Silva, “Studies on the Encapsulation of Diclofenac in Small Unilamellar Liposomes of Soya Phosphatidylcholin,” Colloids and Surfaces B: Biointerfaces, Vol. 39, No. 4, 2004, pp. 151-158. doi:10.1016/j.colsurfb.2004.09.004
- P. Karande and S. Mitragotri, “Enhancement of Transdermal Drug Delivery via Synergistic Action of Chemicals,” Biochimica et Biophysica Acta (BBA)-Biomembranes, Vol. 1788, No. 11, 2009, pp. 2362-2373. doi:10.1016/j.bbamem.2009.08.015
- M. M. A. Elsayed, O. Y. Abdallah, V. F. Naggar, et al., “Lipid Vesicles for Skin Delivery of Drugs: Reviewing Three Decades of Research,” International Journal of Pharmaceutics, Vol. 332, No. 1-2, 2007, pp. 1-16. doi:10.1016/j.ijpharm.2006.12.005
- J. A. Zhang, G. Anyarambhatla, L. Ma, et al., “Development and Characterization of a Novel Cremophor EL Free Liposome-Based Paclitaxel (LEP-ETU) Formulation,” European Journal of Pharmaceutics and Biopharmaceutics, Vol. 59, No. 1, 2005, pp. 177-187. doi:10.1016/j.ejpb.2004.06.009
- K. Shimizu, M. Osada, K. Takemoto, et al., “Temperature-Dependent Transfer of Amphotericin B from Liposomal Membrane of Ambiosome to Fungal Cell Membrane,” Journal of Controlled Release, Vol. 141, No. 2, 2010, pp. 208-215. doi:10.1016/j.jconrel.2009.09.019
- C. Ren, L. Fang, L. Ling, et al., “Designand in Vivo Evaluation of an Indapamide Transdermal Patch,” International Journal of Pharmaceutics, Vol. 370, No. 1-2, 2009, pp. 129-135. doi:10.1016/j.ijpharm.2008.12.004
- E. Gutschke, S. Bracht, S. Nagel, et al., “Adhesion Testing of Transdermal Matrix Patches with a Probe Tack Test: In Vitro and in Vivo Evaluation,” European Journal of Pharmaceutics and Biopharmaceutics, Vol. 75, No. 3, 2009, pp. 399-404. doi:10.1016/j.ejpb.2010.03.016
- T. Garg, S. Jain, S. H. Pal, et al., “Elastic liposomal Formulation for Sustained Delivery of Antimigraine Drugs: In Vitro Characterization and Biological Evaluation,” Drug Development and Industrial Pharmacy, Vol. 34, No. 10, 2008, pp. 1100-1110. doi:10.1080/03639040801965079