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Antioxidants as effective remedies at hepatotoxic action of carbon tetrachloride
Institute of Molecular Biology, Yerevan, Armenia
Scientific and Technological Center of Organic and Pharmaceutical Chemistry, NAS RA, Yerevan, Armenia
H. Buniatian Institute of Biochemistry, NAS RA, Yerevan, Armenia
Institute of Molecular Biology, Yerevan, Armenia
Institute of Molecular Biology, Yerevan, Armenia
Scientific and Technological Center of Organic and Pharmaceutical Chemistry, NAS RA, Yerevan, Armenia
Scientific and Technological Center of Organic and Pharmaceutical Chemistry, NAS RA, Yerevan, Armenia
- 1 Institute of Molecular Biology, Yerevan, Armenia
- 2 Scientific and Technological Center of Organic and Pharmaceutical Chemistry, NAS RA, Yerevan, Armenia
- 3 H. Buniatian Institute of Biochemistry, NAS RA, Yerevan, Armenia
- 4 Institute of Molecular Biology, Yerevan, Armenia
- 5 Institute of Molecular Biology, Yerevan, Armenia
- 6 Scientific and Technological Center of Organic and Pharmaceutical Chemistry, NAS RA, Yerevan, Armenia
- 7 Scientific and Technological Center of Organic and Pharmaceutical Chemistry, NAS RA, Yerevan, Armenia
Journal of Biophysical Chemistry·Volume 05 (2014)·Pages 1–4·Published 15 January 2014·DOI10.4236/jbpc.2014.51001
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Abstract
The liver, as the central metabolic organ, plays an important role in metabolism of carbohydrates, lipids and proteins. In the environment, there are many hepatotoxic xenobiotics. CCl4 is a free radical toxic for organelles of hepatocytes. The presented work was studying the character of ultrastructural changes in CCl4-intoxicated hepatocytes as well as the tissue after treatment by grape seed extract (GSE), α-tocopherol (α-T). As a result of cell bioremediation effect and reactions against corruptive factors, the liver has a high regeneration ability.
KeywordsCCl4GSEα-TocopherolUltrastructural ChangesIntoxicated HepatocytesElectron Microscopy
- Dzhivanyan, K.A. and Adamyan, N.V. (2001) About features of ultrastructure of a liver of birds in norm and after partial hepatoctomy. The Russian Morphological Sheets, Moscow, 3-4, 26-27.
- Fausto, N. and Campbell, J.S. (2003) The role of hepatocytes and oval cells in liver regeneration and repopulation. Mechanisms of Development, 120, 117-130. http://dx.doi.org/10.1016/S0925-4773(02)00338-6
- Loginov, A.S. and Block, Yu.E. (1987) Chronical hepatitis and liver cirrhosis. Medicine, 272.
- Powell, E.E., Jonsson, J.R. and Clouston, A.D. (2005) Steatosis: Cofactor in other liver diseases. Hepatology, 42, 5-13. http://dx.doi.org/10.1002/hep.20750
- Simonyan, А.А., Margaryan, А.S., Hovnanyan, К.О., Asatryan, R.G. and Hov?nanyan, М.К. (2007) Effect of antioxi?dants on white rats with liver intoxica?tion induced by carbon tetrachloride: Ul?trastructural analysis. Proceedings of the International Symposium under the Aegis of UNESCO “Problems of Biochemis?try, Molecular and Radiation Biology and Genetics”, Yerevan, 2007, 74-75.
- Craciun, C., Ardelan, A., Ciobanu, C., Rusu, M.A., Puica, C., Tamas, M. and Craciun, V. (2004) Structural-funtional studies regarding the effect of Berberia vulgaris extract on rat intoxicated liver. Proceedings of 13th European Microscopy Congress, Antwerp, 3, 463-464.
- Sabatini, D.D., Bensch, K. and Barnett, R.J. (1963) Cyto-chemistry and electron microscopy—The preservation of cellula?r ultrastructure and enzymatic activity by aldehyde fixation. The Journal of Cell Biology, 17, 19-58.
- Venable, J.H. and Coggeshall, R. (1965) A simplified lead citrate stain for use in electron microscopy. The Journal of Cell Biology, 25, 407-408. http://dx.doi.org/10.1083/jcb.25.2.407
- Sarkisov, D.S. (1970) Regeneration and its clinical significance. Medi?cine, 281.