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Atherogenic Indices and HDL Particle Size as Laboratory Parameters to Evaluate Cardiovascular Risk in the Presence of Dyslipidemia

¹ Clinical Biochemistry Laboratory, Department of Clinical and Toxicological Analysis , Faculty of Pharmacy, Federal University of Bahia/UFBA, Salvador, Brazil
² Naval Hospital of Salvador, Brazilian Marine Forces, Salvador, Brazil
³ Lipid Metabolism Laboratory of the Heart Institute (InCor-Clinical Hospital of Medical School), Faculty of Pharmacy, University of S?o Paulo/USP, S?o Paulo, Brazil
⁴ Naval Hospital of Salvador, Brazilian Marine Forces, Salvador, Brazil
⁵ Lipid Metabolism Laboratory of the Heart Institute (InCor-Clinical Hospital of Medical School), Faculty of Pharmacy, University of S?o Paulo/USP, S?o Paulo, Brazil
⁶ Ana Neri Hospital, SESAB and Federal University of Bahia/UFBA Faculty of Medicine, Salvador, Brazil
⁷ Laboratory of Research in Immunology (LAPIM), Department of Clinical and Toxicological Analysis, Faculty of Pharmacy, Federal University of Bahia/UFBA, Salvador, Brazil
⁸ Laboratory of Molecular Biology and Genetics at Center of Agricultural, Environmental and Biological Sciences (CCAAB-UFRB), Cruz das Almas, Brazil
⁹ Lipid Metabolism Laboratory of the Heart Institute (InCor-Clinical Hospital of Medical School), Faculty of Pharmacy, University of S?o Paulo/USP, S?o Paulo, Brazil；Faculty of Pharmaceutical Sciences, Clinical Chemistry Department, University of S?o Paulo/USP, S?o Paulo, Brazil
¹⁰ Clinical Biochemistry Laboratory, Department of Clinical and Toxicological Analysis , Faculty of Pharmacy,Federal University of Bahia/UFBA, Salvador, Brazil；Ana Neri Hospital, SESAB and Federal University of Bahia/UFBA Faculty of Medicine, Salvador, Brazil；Central Clinical Laboratory of Professor Edgar Santos University Hospital, Federal University of Bahia/UFBA, Salvador, Brazil

Journal of Biophysical Chemistry·Volume 05 (2014)·Pages 24–32·Published 23 April 2014·DOI10.4236/jbpc.2014.52004

Abstract

Dyslipidemia may influence enzymes and transfer proteins needed to the lipoprotein particle remodeling. Calculated indices and evaluation of lipoprotein particle size have widely been used to predict cardiovascular risk. The aim of this study was to evaluate HDL particle size and LDL particle size estimate based on TG/HDL-C as well as apoB/apoA-I ratio as possible marker and atherogenic indices, respectively, of cardiovascular disease risk in the presence of dyslipidemia. We evaluated 100 individuals of both gender, without treatment with lipid-lowering drugs, 27 normolipidemic and 73 dyslipidemic, such as isolated hypercholesterolemia (n = 16), isolated hypertriglyceridemia (n = 17), low HDL-C (n = 26) and mixed dyslipidemia (n = 14). The HDL particle size did not differ between groups. The TG/HDL-C ratio was higher in groups with isolated hypertriglyceridemia (4.2 ± 1.5), low HDL-C (5.2 ± 3.1) and mixed dyslipidemia (5.3 ± 1.6). The apoB/apoA-I ratio was increased in all groups of dyslipidemia (apoB/apoA-I > 0.5) when compared to normolipidemic (apoB/apoA-I = 0.5, p < 0.001). There was a positive linear correlation between the TG/HDL-C ratio and the apoB/apoA-I ratio in low HDL-C group (r = 0.507, p = 0.008, Spearman). The results suggest that the evaluations of lipoproteins particles remodeling markers and the use of calculated indices may contribute to the evaluation of cardiovascular disease risk when dyslipidemia take place.

KeywordsDyslipidemiaAtherogenic IndicesCardiovascular Risk

Imes, C.C. and Austin, M.A. (2013) Low-Density Lipoprotein Cholesterol, Apolipoprotein B, and Risk of Coronary Heart Disease: From Familial Hyperlipidemia to Genomics. Biological Research for Nursing, 15, 292-308. http://dx.doi.org/10.1177/1099800412436967
Carr, M.C., Ayyobi, A.F., Murdoch, S.J., Deeb, S.S. and Brunzell, J.D. (2002) Contribution of Hepatic Lipase, Lipo- protein Lipase, and Cholesteryl Ester Transfer Protein to LDL and HDL Heterogeneity in Healthy Women. Arteriosclerosis, Thrombosis, and Vascular Biology, 22, 667-673. http://dx.doi.org/10.1161/01.ATV.0000013284.47317.95
Cheung, M.C., Wolfbauer, G., Deguchi, H., Fernandez, J.A., Griffin, J.H. and Albers, J.J. (2009) Human Plasma Phospholipid Transfer Protein Specific Activity Is Correlated with HDL Size: Implications for Lipoprotein Physiology. Biochimica et Biophysica Acta, 1791, 206-211. http://dx.doi.org/10.1016/j.bbalip.2008.12.010
Deeb, S.S., Zambon, A., Carr, M.C., Ayyobi, A.F. and Brunzell, J.D. (2003) Hepatic Lipase and Dyslipidemia: Interactions among Genetic Variants, Obesity, Gender, and Diet. The Journal of Lipid Research, 44, 279-286. http://dx.doi.org/10.1194/jlr.R200017-JLR200
Treguier, M., Briand, F., Boubacar, A., Andre, A., Magot, T., Nguyen, P., Krempf, M., Sulpice, T. and Ouguerram, K. (2001) Diet-Induced Dyslipidemia Impairs Reverse Cholesterol Transport in Hamsters. European Journal of Clinical Investigation, 41, 921-928. http://dx.doi.org/10.1111/j.1365-2362.2011.02478.x
Kontush, A. and Chapman, M.J. (2006) Antiatherogenic Small, Dense HDL: Guardian Angel of the Arterial Wall? Nature Clinical Practice Cardiovascular Medicine, 3, 144-153. http://dx.doi.org/10.1038/ncpcardio0500
Lima, E.S. and Maranhao, R.C. (2004) Rapid, Simple Laser-Light-Scattering Method for HDL Particle Sizing in Whole Plasma. Clinical Chemistry, 50, 1086-1088. http://dx.doi.org/10.1373/clinchem.2004.032383
Barter, P., Kastelein, J., Nunn, A. and Hobbs, R. (2003) High-Density Lipoproteins (HDLs) and Atherosclerosis: The Unanswered Questions. Atheroscler, 168, 195-211. http://dx.doi.org/10.1016/S0021-9150(03)00006-6
Arsenalt, B.J., Lemieux, I., Despres, J.P., Gagnon, P., Wareham, N.J., Stroes, E.S.J., Kastelein, J.J.P., Khaw, K. and Boekholdt, S.M. (2009) HDL Particle Size and the Risk of Coronary Heart Disease in Apparently Healthy Men and Women: The EPIC-Norfolk Prospective Population Study. Atheroscler, 206, 276-281. http://dx.doi.org/10.1016/j.atherosclerosis.2009.01.044

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Atherogenic Indices and HDL Particle Size as Laboratory Parameters to Evaluate Cardiovascular Risk in the Presence of Dyslipidemia

Abstract

References (31)