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The molecular mechanism for DDT detoxification in Anopheles gambiae: A molecular docking study
Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA
- 1 Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA
Journal of Biophysical Chemistry·Volume 02 (2011)·Pages 135–136·Published 19 May 2011·DOI10.4236/jbpc.2011.22016
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Abstract
The epsilon class glutathione-S-transferase of <i>Anopheles gambiae</i>, agGSTe2, is capable of metabolizing DDT. A molecular docking analysis of DDT with agGSTe2 support an E2 elimination mechanism wherein the glutathione sulfur serves as the base to convert DDT to DDE.
KeywordsMalariaDDTAnopheles GambiaeGlutathione S-transferaseDocking
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