Quantitative Survey of Longitudinal Usage Benefit of the Same Anti-Aging Skincare Product Containing Galactomyces Ferment Filtrate (Pitera) for Anti-Aging and Youthful Skin in Those Initiating Use in Their 20s and Early 30s and Continuing until Their 30s, 40s, and over 50s

Abstract

Background: Facial skin aging is a major concern, especially among women. For many, it is important to limit facial skin aging and maintain youthful healthy skin for as long as possible. However, little research has longitudinally investigated the efficacy of skincare product usage on facial skin aging. Therefore, we conducted a quantitative survey to longitudinally compare the skin of individuals with continuous long-term use of the same skincare formula to that of control participants. Purpose: To elucidate anti skin aging benefit by longitudinal usage of the same skin care formula, and whether skin aging-related SNPs variation influenced on the skin aging. Method : We measured facial skin aging parameters of texture, pore, wrinkles and tone together with skin hydration and elasticity in 141 East Asian females (mean age 47.1, SD 7.81) who had continually used the same anti-aging skincare formula (SK-II Facial Treatment Essence: FTE) containing Galactomyces Ferment Filtrate (Pitera) from a young age. The average duration of FTE use in this group was 13.1 ± 7.81 years. As a control, we also included 137 Asian females (mean age 47.3, SD 9.51) with no history of using the FTE product. In addition, the skin aging-related SNPs [GPX1 (rs1050450), SOD2 (rs4880), and MMP1 (rs1799750)] were determined using oral cavity swab samples and PCR to understand the genetic potential or predisposition for skin aging. Result: The findings demonstrated that the Long-term FTE group had excellent skin appearance and physical properties for all measured variables, namely, skin texture, pores, wrinkles, tone, spots, hydration, TEWL, and mechanical elasticity, which were significantly better than those of the Control group. There were significant relationships between the parameters of skin aging appearance and skin aging-related SNPs in the Control group, however, not in the Long-term FTE group. Moreover, the frequencies of genotypes of skin aging-related SNPs did not differ significantly between the two groups. Conclusion: These results suggest that longitudinal usage of an appropriate cosmetic agent from a younger age is beneficial and decelerates facial skin aging.