Research ArticleOpen AccessGoogle Scholar indexed
Neocollagenesis in Non-Invasive Aesthetic Treatments
Wellcomet GmbH, Karlsruhe, Germany.
- 1 Wellcomet GmbH, Karlsruhe, Germany.
Journal of Cosmetics, Dermatological Sciences and Applications·Volume 03 (2013)·Pages 1–5·Published 9 January 2013·DOI10.4236/jcdsa.2013.31A001
Copy link · social · email
Abstract
Dermal neocollagenesis is often assumed to be the main reason of visible skin improvement after different non-invasive and minimal invasive aesthetic treatments. However, the very slow dynamics of the mature collagen remodelling in the extra cellular matrix (ECM) of dermis, with a half-life time of 15 years, renders every observable upregulation of collagen production insufficient to replace a significant part of the matrix during the short time in which it is claimed skin improvement takes place.
KeywordsNeocollagenesisAesthetic TreatmentsProcollagenMature CollagenTurnover
- J. Varani, R. L. Warner, M. Gharaee-Kermani, S. H. Phan, S. Kang, J. H. Chung, Z. Q. Wang, S. C. Datta, G. J. Fisher and J. J. Voorhees, “Vitamin A Antagonizes Decreased Cell Growth and Elevated Collagen-Degrading Matrix Metalloproteinases and Stimulates Collagen Accumulation in Naturally Aged Human Skin,” Journal of Investigative Dermatology, Vol. 114, No. 3, 2000, pp. 480-486. doi:10.1046/j.1523-1747.2000.00902.x
- S. E. G. Fligiel, J. Varani, S. C. Datta, S. Kang, G. J. Fisher and J. J. Voorhees, “Collagen Degradation in Aged/ Photodamaged Skin in Vivo and after Exposure to Matrix Metalloproteinase-1 in Vitro,” Journal of Investigative Dermatology, Vol. 120, No. 5, 2003, pp. 842-848. doi:10.1046/j.1523-1747.2003.12148.x
- G. J. Fisher, J. Varani and J. J. Voorhees, “Looking Older. Fibroblast Collapse and Therapeutic Applications,” Archive of Dermatology, Vol. 144, No. 5, 2008, pp. 666-672.
- W. A. El-Harake, M. A. Furman, B. Cook, K. S. Nair, J. Kukowski and I. G. Brodsky, “Measurement of Dermal Collagen Synthesis Rate in Vivo in Humans,” American Journal of Physiology, Vol. 274, No. 4, 1998, pp. E586-E591.
- N. Verzijl, J. DeGroot, S. R. Thorpe, R. A. Bank, J. N. Shaw, T. J. Lyons, Bijlsma, F. P. Lafeber, J. W. Baynes and J. M. TeKoppele, “Effect of Collagen Turnover on the Accumulation of Advanced Glycation end Products,” Journal of Biological Chemistry, Vol. 275, No. 15, 2000, pp. 39027-39031. doi:10.1074/jbc.M006700200
- P. R. Mays, R. J. McNulty, J. S. Campa and G. J. Laurent, “Age-Related Changes in Collagen Synthesis and Degradation in Rat Tissues: Importance of Degradation of Newly Synthesized Collagen in Regulating Collagen Production,” Biochemistry Journal, Vol. 276, 1991, pp. 307-313.
- Z. O. Wirtschaftler and A. S. Bentley, “The Influence of Age and Growth Rate on the Extractable Collagen of Skin of Normal Rats,” Laboratory Investigations, Vol. 11, 1962, pp. 316-320.
- J. C. Waterlow and J. M. L. Stephen, “Adaptation of the Rat to a Low-Protein Diet: The Effect of a Reduced Protein Intake on the Pattern of Incorporation of L-[ 14 C] Lysine,” British Journal of Nutrition, Vol. 20, No. 3, 1966, pp. 461-484. doi:10.1079/BJN19660047
- J. H. Chung, J. Y. Seo, H. R. Choi, M. K. Lee, C. S. Youn, G. Rhie, K. H. Cho, K. H. Kim, K. C. Park and H. C. Eun, “Modulation of Skin Collagen Metabolism in Aged and Photoaged Human Skin in Vivo,” Journal of Investigative Dermatology, Vol. 117, No. 5, 2001, pp. 1218-1224. doi:10.1046/j.0022-202x.2001.01544.x