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Subacute Toxicological Analysis of Excessive <i>Staphylococcus epidermidis</i> Administration in Mice
Laboratory of Biochemistry, Department of Pharmacy, Faculty of Pharmaceutical Sciences, Nagasaki International University, Sasebo, Japan
Laboratory of Biochemistry, Department of Pharmacy, Faculty of Pharmaceutical Sciences, Nagasaki International University, Sasebo, Japan
Laboratory of Biochemistry, Department of Pharmacy, Faculty of Pharmaceutical Sciences, Nagasaki International University, Sasebo, Japan
Laboratory of Biochemistry, Department of Pharmacy, Faculty of Pharmaceutical Sciences, Nagasaki International University, Sasebo, Japan
Department of Nutrition, Kyushu Women’s University, Kitakyushu, Japan
- 1 Laboratory of Biochemistry, Department of Pharmacy, Faculty of Pharmaceutical Sciences, Nagasaki International University, Sasebo, Japan
- 2 Laboratory of Biochemistry, Department of Pharmacy, Faculty of Pharmaceutical Sciences, Nagasaki International University, Sasebo, Japan
- 3 Laboratory of Biochemistry, Department of Pharmacy, Faculty of Pharmaceutical Sciences, Nagasaki International University, Sasebo, Japan
- 4 Laboratory of Biochemistry, Department of Pharmacy, Faculty of Pharmaceutical Sciences, Nagasaki International University, Sasebo, Japan
- 5 Department of Nutrition, Kyushu Women’s University, Kitakyushu, Japan
Journal of Cosmetics, Dermatological Sciences and Applications·Volume 03 (2013)·Pages 172–174·Published 15 August 2013·DOI10.4236/jcdsa.2013.33027
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Abstract
We performed subacute toxicological analysis of mice that received repeated oral administration of excess Staphylo coccus epidermidis every day for 4 weeks. No mouse died and no abnormalities of specific internal organs were in duced by excessive S. epidermidis administration . Furthermore, acute toxicity analysis following oral and intraperito neal administration of excess S. epidermidis showed no toxicity in the test mice.
Keywords<i>Staphylococcus epidermidis</i>Skin MicrobiotaSkin CareCosmeticsSubacute Toxicity Analysis
- I. Dekio, H. Hayashi, M. Sakamoto, M. Kitahara, T. Nishikawa, M. Suematsu and Y. Benno, “Detection of Potentially Novel Bacterial Components of the Human Skin Microbiota Using Culture-Independent Molecular Profiling,” Journal of Medical Microbiology, Vol. 54, No. 12, 2005, pp. 1231-1238. doi:10.1099/jmm.0.46075-0
- I. Dekio, M. Sakamoto, H. Hayashi, M. Amagai, M. Suematsu and Y. Benno, “Characterization of Skin Microbiota in Patients with Atopic Dermatitis and in Normal Subjects Using 16S rRNA Gene-Based Comprehensive Analysis,” Journal of Medical Microbiology., Vol. 56, No. 12, 2007, pp. 1675-1683. doi:10.1099/jmm.0.47268-0
- T. Iwase, Y. Uehara, H. Shinji, A. Tajima, H. Seo, K. Takada, T. Agata and Y. Mizunoe, “Staphylococcus epidermidis Esp Inhibits Staphylococcus Aureus Biofilm Formation and Nasal Colonization,” Nature, Vol. 465, No. 7296, 2010, pp. 346-349. doi:10.1038/nature09074
- M. Al-Mahrous, S. K. Sandiford, J. R. Tagg and M. Upton, “Purification and Characterization of a Novel DeltaLysin Variant that Inhibits Staphylococcus Aureus and Has Limited Hemolytic Activity,” Peptides, Vol. 31, No. 9, 2010, pp. 1661-1668. doi:10.1016/j.peptides.2010.06.006
- A. L. Cogen, K. Yamasaki, K. M. Sanchez, R. A. Dorschner, Y. Lai, D. T. MacLeod, J. W. Torpey, M. Otto, V. Nizet, J. E. Kim and R. L. Gallo, “Selective Antimicrobial Action Is Provided by Phenol-Soluble Modulins Derived from Staphylococcus epidermidis, a Normal Resident of the Skin,” Journal of Investigative Dermatology, Vol. 130, No. 1, 2010, pp. 192-200. doi:10.1038/jid.2009.243
- A. Kaneko, S. Kondo, J. Akiyama and K. Okabe, “A New Cosmetic SOD Delivery System Using Skin Surface Resident Staphylococcus epidermidis by Lotions Containing Mn/Zn Ions,” Drug Delivery System, Vol. 12, No. 5, 1997, pp. 339-345. doi:10.2745/dds.12.339
- L. Nilsson, P. Flock and G. Lindberg, “A FibrinogenBinding Protein of Staphylococcus epidermidis,” Infection and Immunity, Vol. 66, No. 6, 1998, pp. 2666-2673.
- M. Otto, “Staphylococcus epidermidis the ‘Accidental’ Pathogen,” Nature Reviews Microbiology, Vol. 7, No. 8, 2009, pp. 555-567. doi:10.1038/nrmicro2182
- G. Hedin, “Staphylococcus epidermidis Hospital Epidemiology and the Detection of Methicillin Resistance,” Scandinavian Journal of Infectious Diseases. Supplementum, Vol. 90, No. 1, 1993, pp. 1-59.
- Y. Q. Zhang, S. X. Ren, H. L. Li, Y. X. Wang, G. Fu, J. Yang, Z. Q. Qin, Y. G. Miao, W. Y. Wang, R. S. Chen, Y. Shen, Z. Chen, Z. H. Yuan, G. P. Zhao, D. Qu, A. Danchin and Y. M. Wen, “Genome-Based Analysis of Virulence Genes in a Non-Biofilm-Forming Staphylococcus epidermidisstrain (ATCC 12228),” Molecular Microbiology, Vol. 49, No. 6, 2003, pp. 1577-1583. doi:10.1046/j.1365-2958.2003.03671.x