A Single Arm, Monocentric, Prospective, Open Label Study to Evaluate Anti-Ageing Efficacy of Human Growth Factors and Cytokines Containing Cosmetic Skin Serum in Indian Female Population — Oak Academic Publishing
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A Single Arm, Monocentric, Prospective, Open Label Study to Evaluate Anti-Ageing Efficacy of Human Growth Factors and Cytokines Containing Cosmetic Skin Serum in Indian Female Population
Manipal Hospital, Bangalore, India
,
Stempeutics Research Pvt. Ltd., Bangalore, India
,
Stempeutics Research Pvt. Ltd., Bangalore, India
,
MS Skin Centre, Bangalore, India
,
MS Skin Centre, Bangalore, India
,
MS Skin Centre, Bangalore, India
,
MS Skin Centre, Bangalore, India
,
Stempeutics Research Pvt. Ltd., Bangalore, India
,
Stempeutics Research Pvt. Ltd., Bangalore, India
1 Manipal Hospital, Bangalore, India
2 Stempeutics Research Pvt. Ltd., Bangalore, India
3 Stempeutics Research Pvt. Ltd., Bangalore, India
4 MS Skin Centre, Bangalore, India
5 MS Skin Centre, Bangalore, India
6 MS Skin Centre, Bangalore, India
7 MS Skin Centre, Bangalore, India
8 Stempeutics Research Pvt. Ltd., Bangalore, India
9 Stempeutics Research Pvt. Ltd., Bangalore, India
Introduction: The use of growth factors and cytokines in skin rejuvenation and reversal of photo ageing is a novel anti-ageing treatment. These factors provide a microenvironment that seems to favor tissue repair and regeneration. Methods: An open label, monocentric, single arm study to evaluate anti-ageing efficacy of conditioned medium obtained from adult human bone-marrow derived allogenic mesenchymal stromal cells (BMMSC) along with excipients formulated into a cosmetic serum, was conducted in 40 Indian female population aged 35 to 60 years, belonging to skin type IV - VI of Norwood Scale for a duration of 90 days. Parameters—fine lines, wrinkles, crow’s feet, evenness of skin tone, skin firmness/laxity, hydration of skin, homogeneity of age spots, and visible pores were used to evaluate the anti-ageing and rejuvenating properties of the test product. Results and Discussion: Improvement was seen in majority of parameters starting from 15 - 30 days. Product was safe and well tolerated as per the dermatologist and subjects’ self-assessment.
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