Two Cases of Hallopeau Type of Pemphigus Vegetans in Two Women in Burkina Faso
- 1 Université Nazi Boni de Bobo-Dioulasso, Bobo-Dioulasso, Burkina Faso
- 2 Université Nazi Boni de Bobo-Dioulasso, Bobo-Dioulasso, Burkina Faso
- 3 Université Nazi Boni de Bobo-Dioulasso, Bobo-Dioulasso, Burkina Faso
- 4 Université Nazi Boni de Bobo-Dioulasso, Bobo-Dioulasso, Burkina Faso
- 5 Université Ki-Zerbo de Ouagadougou, Ouagadougou, Burkina Faso
- 6 Université Ki-Zerbo de Ouagadougou, Ouagadougou, Burkina Faso
Abstract
Pemphigus of Hallopeau (PH) is a mild and pustular form of pemphigus vegetans, termed initially as “pyodermite végétante” described by Hallopeau. We report cases in two black women. Two women aged 32 and 36 respectively (case 1 and case 2) were seen for a pustulosis associated with blisters and erosions. Their history and their review have found the mouth ulcerations. The clinical examination showed pustules on the cephalic end, the trunk, the limbs and the large folds. Lesions had a polycyclic aspect and spread in a centrifugal way, developing towards budding, squamous and scabby erosions quickly surrounded by new pustules. Regression left a pigmented macula. Histological examination of the skin lesion showed images similar to vulgaris pemphigus (PV), together with hyperacanthosis and papillomatosis. Aspects observed in immunofluorescence were identical to those of PV (case1). General corticoid therapy led to a rapid disappearance of lesions in Case 1 but in Case 2 the Lever protocol combining corticoid and methotrexate have been used. PH is rarely described in our regions. Clinical diagnosis is not obvious for the uninitiated. Beyond the clinical presentation, PH has the same paraclinical diagnosis and the same treatment as PV.
- Pizzariello, G., Olivares, L. and Forero, O., D’Atri, G., Pardal, P.F. and Anaya, J. (2011) Retrospective Study of Hallopeau-Type Pemphigus Vegetans throughout a 20-Year Period. Review of the Literature. Dermatología Argentina, 17, 294-300.
- Nelson, CG, Apisarnthanarax, P., Bean, S.F. and Mullins, J.F. (1977) Pemphigus Vegetans of Hallopeau: Immunofluorescent Studies. JAMA Dermatology, 113, 942-945. https://doi.org/10.1001/archderm.1977.01640070076011
- Saurat, J.H., Lachapelle, J.M., Lipsker, D. and Thomas, L. (2004) Pemphigus Auto-Immuns. In: Borradori, L., Parmentier, L. and Saurat, J.H., Eds., Dermatologie et infection sexuellement transmissible, 300-301.
- Fujimoto, W., Hirano, N., Miyashita, M., Arata, J. and Saito, C. (1991) Pemphigus Vegetans Presenting with Deafness, Otalgia and Facial Nerve Paralysis. British Journal of Dermatology, 6, 609-610. https://doi.org/10.1111/j.1365-2133.1991.tb04961.x
- Parodi, H.A.S., Stanley, J.R., Ciaccio, M. and Rebora, A. (1988) Epidermal Antigens in Pemphigus Vegetans. Report of a Box. British Journal of Dermatology, 119, 799-802. https://doi.org/10.1111/j.1365-2133.1988.tb03507.x
- Martel, P. and Joly, P. (2001) Pemphigus. The Encycl Med Chir, Dermatology, 98-250-A-10, 28 p.
- Benoit Corven, C., Carvalho, P., Prost, C., et al. (2003) Treatment of Pemphigus Vulgaris by Azathioprine and Low Doses of Prednisone (Diagram of Lift). Annales de Dermatologie et de Vénéréologie, 130, 13-15.