Treatment of Kaposi’s Sarcoma by Combination of Zinc Sulfate and Propranolol
- 1 Department of Dermatology, College of Medicine, University of Baghdad, Baghdad, Iraq
- 2 Iraqi and Arab Board for Dermatology & Venereology, Baghdad Teaching Hospital, Baghdad, Iraq
Abstract
Kaposi ’ s sarcoma (KS) in Iraq has been reported as sporadic cases of elderly of Iraqi population but after exposure to depleted uranium radiation in early 1991, the frequency of the disease is increasing appearing in younger age with more wide spread and aggressive in nature. The re is no satisfactory oral treatment to control this disease. The aim of the present work is to record a new regime of therapy using oral zinc sulfate and oral propanolol. Four patients with wide spread Kaposi’s sarcoma (KS) were treated with oral and topical zinc sulfate solution and oral propranolol. The duration of treatment was between 6 - 12 months and the response started few weeks and was obvious after one month. Most old lesions were resolved leaving post inflammatory hyperpigmentation and few lesions appeared during course of treatment.
- Calonje (2010) Soft-Tissue Tumours and Tumour-Like Conditions. In: Burns, T., Breathnach, S., Griffiths, C. and Cox, N., Eds., Rook’s Textbook of Dermatology, 8th Edition, Wiley-Blackwell, 56, 33-37.
- Weiss, R.A., Whitby, D. and Talbot, S. (1998) Human Herpesvirus Type 8 and Kaposi’s Sarcoma. JNCI Monographs, 23, 51-54. https://doi.org/10.1093/oxfordjournals.jncimonographs.a024173
- Al-Saleem, T., Sharquie, K.E., Alash, N., Naimi, A. and Sha’arbaf, H.H. (1984) Kaposi’s Sarcoma in Iraqi Patients. Proceedings of the First Scientific Conference of Medical College, University of Baghdad, Baghdad, 24 April 1984.
- Al-Waiz, M., Sharquie, K.E. and Al-Hamdani, G.A. (2003) Un Upsurge of New Cases of Kaposi’s Sarcoma in Iraqi Patients. Saudi Medical Journal, 24, 224-225.
- Appero, J.W., Conant, M.A., Wolfe, S.F. and Berger, T.G. (1993) Kaposis Sarcoma. Epidemiology, Pathogenesis, Histology, Clinical Spectrum, Staging Criteria and Therapy. Journal of the American Academy of Dermatology, 28, 371-395.
- North, P.E. and Kincannon, J. (2012) Vascular Neoplasms and Neoplastic-Like Proliferations. In: Bolognia, J.L., Jorizzo, J.L. and Schaffer, J.V., Eds., Dermatology, 3rd Edition, Elsevier Saunders, 114, 1932-1935.
- Storch, C.H. and Hoeger, P.H. (2010) Propranolol for Infantile Heamangiomas: Insight into the Molecular Mechanism of Action. British Journal of Dermatology, 163, 269-274. https://doi.org/10.1111/j.1365-2133.2010.09848.x
- Sharquie, K.E., Khorsheed, A.A. and Al-Nuaimy, A.A. (2007) Topical Zinc Sulphate Solution for Treatment of Viral Warts. Saudi Medical Journal, 28, 1418-1421.
- Sharquie, K.E., Najim, R.A., Farjou, I.B. and Al-Timimi, D.J. (2001) Oral Zinc Sulphate in the Treatment of Acute Cutaneous Leishmaniasis. Clinical and Experimental Dermatology, 26, 21-26. https://doi.org/10.1046/j.1365-2230.2001.00752.x
- Prasad, A.S. (2009) Zinc: Role in Immunity, Oxidative Stress and Chronic Inflammation. Current Opinion in Clinical Nutrition & Metabolic Care, 12, 646-652. https://doi.org/10.1097/MCO.0b013e3283312956
- Yamaoka, J., Kume, T., Akaike, A. and Miyachi, Y. (2000) Suppressive Effect of Zinc Ion on iNOS Expression Induced by Interferon-Gamma or Tumor Necrosis Factor-Alpha in Murine Keratinocytes. Journal of the Dermatological Science, 23, 27-35. https://doi.org/10.1016/S0923-1811(99)00062-6
- Schwartz, J., Marsh, R. and Draelos, Z. (2005) Zinc and Skin Health: Overview of Physiology and Pharmacology. Dermatologic Surgery, 31, 837-847. https://doi.org/10.1111/j.1524-4725.2005.31729