Soothing Efficacy and Tolerability of a Skin Care Product Containing Live Lactobacillus rhamnosus Bacteria and Berry Seed Oils on Atopic Dermatitis Lesions — Oak Academic Publishing
Research ArticleOpen AccessGoogle Scholar indexed
Soothing Efficacy and Tolerability of a Skin Care Product Containing Live Lactobacillus rhamnosus Bacteria and Berry Seed Oils on Atopic Dermatitis Lesions
Background: Atopic dermatitis (AD) is a chronic pruritic inflammatory skin disease characterized by a reduced microbiome diversity which favours the skin colonization with pathogenic bacteria, mainly with Staphylococcus aureus . A novel approach to the management of several skin diseases, including AD, involves the use of specific beneficial probiotic bacteria aimed at restoring the skin microbiome balance and decreasing the skin colonization with pathogens. Objective: This study assessed the soothing efficacy and tolerability of a new probiotic-based skin care product combining two live Lactobacillus rhamnosus strains and berry seed oils on eczematous lesions in subjects with atopic skin. Patients and Methods: Twenty-five adults with atopic skin and presenting at least one inflammatory lesion applied the product on the defined lesion for 28 days, once to twice daily. Severity of eczema signs (EASI score) and intensity of pruritus (VAS) were assessed, and digital images were captured following treatment. Cutaneous tolerability and subject satisfaction were also investigated. Results: A statistically significant decrease in mean EASI score was observed after 28 days (- 27%, p = 0.011). A visible improvement in skin aspect was observed in 67% of the subjects on week 4. On average, the intensity of pruritus decreased by 57% as compared to baseline (p = 0.011). This effect was observed in 86% of the subjects. No relevant adverse reactions were observed following treatment with the skin care product and the majority of the subjects appreciated the product for its general characteristics, properties, and efficacy. Conclusion: The results suggest that this skin care product containing two live Lactobacillus rhamnosus strains and berry seed oils could be used for the treatment of eczematous lesions in subjects with atopic skin.
Nutten, S. (2015) Atopic Dermatitis: Global Epidemiology and Risk Factors. Annals of Nutrition & Metabolism, 66, 8-16. https://doi.org/10.1159/000370220
Eichenfield, L.F., Tom, W.L., Chamlin, S.L., Feldman, S.R., Hanifin, J.M., Simpson, E.L., et al. (2014) Guidelines of Care for the Management of Atopic Dermatitis: Section 1. Diagnosis and Assessment of Atopic Dermatitis. Journal of the American Academy of Dermatology, 70, 338-351. https://doi.org/10.1016/j.jaad.2013.10.010
Avena-Woods, C. (2017) Overview of Atopic Dermatitis. The American Journal of Managed Care, 23, S115-S123.
Malajian, D. and Guttman-Yassky, E. (2015) New Pathogenic and Therapeutic Paradigms in Atopic Dermatitis. Cytokine, 73, 311-318. https://doi.org/10.1016/j.cyto.2014.11.023
Marks, J.G. and Miller, J.J. (2019) 8—Eczematous Rashes. In: Eds., Lookingbill and Marks’Principles of Dermatology, 6th Edition, Elsevier, London, 95-112.
Drucker, A.M. (2017) Atopic Dermatitis: Burden of Illness, Quality of Life, and Associated Complications. Allergy and Asthma Proceedings, 38, 3-8. https://doi.org/10.2500/aap.2017.38.4005
Lin, Y.T., Wang, C.T. and Chiang, B.L. (2007) Role of Bacterial Pathogens in Atopic Dermatitis. Clinical Reviews in Allergy & Immunology, 33, 167-177. https://doi.org/10.1007/s12016-007-0044-5
Geoghegan, J.A., Irvine, A.D. and Foster, T.J. (2018) Staphylococcus aureus and Atopic Dermatitis: A Complex and Evolving Relationship. Trends in Microbiology, 26, 484-497. https://doi.org/10.1016/j.tim.2017.11.008
Kobayashi, T., Glatz, M., Horiuchi, K., Kawasaki, H., Akiyama, H., Kaplan, D.H., et al. (2015) Dysbiosis and Staphylococcus aureus Colonization Drives Inflammation in Atopic Dermatitis. Immunity, 42, 756-766. https://doi.org/10.1016/j.immuni.2015.03.014
Weidinger, S. and Novak, N. (2016) Atopic Dermatitis. The Lancet (London, England), 387, 1109-1122. https://doi.org/10.1016/S0140-6736(15)00149-X
Eichenfield, L.F., Tom, W.L., Berger, T.G., Krol, A., Paller, A.S., Schwarzenberger, K., et al. (2014) Guidelines of Care for the Management of Atopic Dermatitis: Section 2. Management and Treatment of Atopic Dermatitis with Topical Therapies. Journal of the American Academy of Dermatology, 71, 116-132. https://doi.org/10.1016/j.jaad.2014.03.023
Roudsari, M.R., Karimi, R., Sohrabvandi, S. and Mortazavian, A.M. (2015) Health Effects of Probiotics on the Skin. Critical Reviews in Food Science and Nutrition, 55, 1219-1240. https://doi.org/10.1080/10408398.2012.680078
Muizzuddin, N., Maher, W., Sullivan, M., Schnittger, S., Mammone, T. (2012) Physiological effect of a probiotic on skin. Journal of cosmetic science, 63, 385-395.
Mottin, V.H.M. and Suyenaga, E.S. (2018) An Approach on the Potential Use of Probiotics in the Treatment of Skin Conditions: Acne and Atopic Dermatitis. International Journal of Dermatology, 57, 1425-1432. https://doi.org/10.1111/ijd.13972
Rather, I.A., Bajpai, V.K., Kumar, S., Lim, J., Paek, W.K. and Park, Y.H. (2016) Probiotics and Atopic Dermatitis: An Overview. Frontiers in Microbiology, 7, 507. https://doi.org/10.3389/fmicb.2016.00507
Al-Ghazzewi, F.H. and Tester, R.F. (2014) Impact of Prebiotics and Probiotics on Skin Health. Beneficial Microbes, 5, 99-107. https://doi.org/10.3920/BM2013.0040
Notay, M., Foolad, N. and Vaughn, A.R. (2017) Probiotics, Prebiotics, and Synbiotics for the Treatment and Prevention of Adult Dermatological Diseases. American Journal of Clinical Dermatology, 18, 721-732. https://doi.org/10.1007/s40257-017-0300-2
Gueniche, A., Hennino, A., Goujon, C., Dahel, K., Bastien, P., Martin, R., et al. (2006) Improvement of Atopic Dermatitis Skin Symptoms by Vitreoscilla Filiformis Bacterial Extract. European Journal of Dermatology: EJD, 16, 380-384.
Gueniche, A., Bastien, P., Ovigne, J.M., Kermici, M., Courchay, G., Chevalier, V., et al. (2010) Bifidobacterium Longum Lysate, a New Ingredient for Reactive Skin. Experimental Dermatology, 19, e1-e8. https://doi.org/10.1111/j.1600-0625.2009.00932.x
Blanchet-Rethore, S., Bourdes, V., Mercenier, A., Haddar, C.H., Verhoeven, P.O. and Andres, P. (2017) Effect of a Lotion Containing the Heat-Treated Probiotic Strain Lactobacillus Johnsonii Ncc 533 on Staphylococcus aureus Colonization in Atopic Dermatitis. Clinical, Cosmetic and Investigational Dermatology, 10, 249-257. https://doi.org/10.2147/CCID.S135529
Valdez, J.C., Peral, M.C., Rachid, M., Santana, M. and Perdigon, G. (2005) Interference of Lactobacillus Plantarum with Pseudomonas Aeruginosa in Vitro and in Infected Burns: The Potential Use of Probiotics in Wound Treatment. Clinical Microbiology and Infection: The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases, 11, 472-479. https://doi.org/10.1111/j.1469-0691.2005.01142.x
Prince, T., McBain, A.J. and O’Neill, C.A. (2012) Lactobacillus reuteri Protects Epidermal Keratinocytes from Staphylococcus aureus-Induced Cell Death by Competitive Exclusion. Applied and Environmental Microbiology, 78, 5119-5126. https://doi.org/10.1128/AEM.00595-12
Mohammedsaeed, W., McBain, A.J., Cruickshank, S.M. and O’Neill, C.A. (2014) Lactobacillus rhamnosus gg Inhibits the Toxic Effects of Staphylococcus aureus on Epidermal Keratinocytes. Applied and Environmental Microbiology, 80, 5773-5781. https://doi.org/10.1128/AEM.00861-14
Fabbrocini, G., Bertona, M., Picazo, O., Pareja-Galeano, H., Monfrecola, G. and Emanuele, E. (2016) Supplementation with Lactobacillus rhamnosus sp1 Normalises Skin Expression of Genes Implicated in Insulin Signalling and Improves Adult Acne. Beneficial Microbes, 7, 625-630. https://doi.org/10.3920/BM2016.0089
Lacombe, A. and Wu, V.C.H. (2017) The Potential of Berries to Serve as Selective Inhibitors of Pathogens and Promoters of Beneficial Microorganisms. Food Quality and Safety, 1, 3-12. https://doi.org/10.1093/fqsafe/fyx001
Puupponen-Pimia, R., Nohynek, L., Alakomi, H.L. and Oksman-Caldentey, K.M. (2005) Bioactive Berry Compounds-Novel Tools against Human Pathogens. Applied Microbiology and Biotechnology, 67, 8-18. https://doi.org/10.1007/s00253-004-1817-x
Lacombe, A., Wu, V.C., White, J., Tadepalli, S. and Andre, E.E. (2012) The Antimicrobial Properties of the Lowbush Blueberry (Vaccinium Angustifolium) Fractional Components against Foodborne Pathogens and the Conservation of Probiotic Lactobacillus rhamnosus. Food Microbiology, 30, 124-131. https://doi.org/10.1016/j.fm.2011.10.006