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Improvement of Atrophic Acne Scar and Skin Complexity by Combination of Aqueous Human Placenta Extract and Mesenchymal Stem Cell Mesotherapy
Laboratory of Cell-Based Assay and Innovations, Biotechnology, Suranaree University of Technology, Nakhon Ratchasima, Thailand
LBM Stem Cell Research Unit, Life Balance Methodology Co., Ltd., Bangkok, Thailand
Sangkhom Hospital, Nongkhai Provincial Health Office, Nongkhai, Thailand
LBM Stem Cell Research Unit, Life Balance Methodology Co., Ltd., Bangkok, Thailand
National Institute of Health, Ministry of Public Health, Nonthaburi, Thailand
Laboratory of Cell-Based Assay and Innovations, Biotechnology, Suranaree University of Technology, Nakhon Ratchasima, Thailand
- 1 Laboratory of Cell-Based Assay and Innovations, Biotechnology, Suranaree University of Technology, Nakhon Ratchasima, Thailand
- 2 LBM Stem Cell Research Unit, Life Balance Methodology Co., Ltd., Bangkok, Thailand
- 3 Sangkhom Hospital, Nongkhai Provincial Health Office, Nongkhai, Thailand
- 4 LBM Stem Cell Research Unit, Life Balance Methodology Co., Ltd., Bangkok, Thailand
- 5 National Institute of Health, Ministry of Public Health, Nonthaburi, Thailand
- 6 Laboratory of Cell-Based Assay and Innovations, Biotechnology, Suranaree University of Technology, Nakhon Ratchasima, Thailand
Journal of Cosmetics, Dermatological Sciences and Applications·Volume 10 (2020)·Pages 1–7·Published 22 January 2020·DOI10.4236/jcdsa.2020.101001
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Abstract
Atrophic scars, a permanent complication of severe acne, have negative effect on psychology in adolescent. The treatment of atrophic scar is depended on types of scar and it is difficult to improve by a single treatment. Mesenchymal stem cell is a scientific approval for surgery scar treatment and wound healing. We present a case report of female presented with atrophic acne scar distributed on both cheeks. The case aims to prove that the combination of MSCs and aqueous human placenta extract (RGF ® ) contained bioactive therapeutic molecules obviously promoted the improvement of skin scar to reach the optimal outcomes. We first found that MSCs-contained human placenta extract solution combination subcision improves the atrophic acne scar and skin complexity by enhancement of skin cell regeneration.
KeywordsAtrophic ScarMesenchymal Stem CellsHuman Placenta ExtractMesotherapySkinRegeneration
- Connolly, D., Vu, H.L., Mariwalla, K., et al. (2017) Acne Scarring-Pathogenesis, Evaluation, and Treatment Options. The Journal of Clinical and Aesthetic Dermatology, 10, 12-23.
- Capitanio, B., Sinagra, J.L., Bordignon, V., et al. (2010) Underestimated Clinical Features of Postadolescent Acne. Journal of the American Academy of Dermatology, 63, 782-788. https://doi.org/10.1016/j.jaad.2009.11.021
- Basta-Juzbasic, A. (2010) Current Therapeutic Approach to Acne Scars. Acta Dermatovenerologica Croatica, 18, 171-175.
- Goodman, G.J. and Baron, J.A. (2006) Postacne Scarring: A Quantitative Global Scarring Grading System. Journal of Cosmetic Dermatology, 5, 48-52. https://doi.org/10.1111/j.1473-2165.2006.00222.x
- Lanci, A., Merlo, B., Mariella, J., et al. (2019) Heterologous Wharton’s Jelly Derived Mesenchymal Stem Cells Application on a Large Chronic Skin Wound in a 6-Month-Old Filly. Frontiers in Veterinary Science, 6, 9. https://doi.org/10.3389/fvets.2019.00009
- Nakagawa, H., Akita, S., Fukui, M., et al. (2005) Human Mesenchymal Stem Cells Successfully Improve Skin-Substitute Wound Healing. British Journal of Dermatology, 153, 29-36. https://doi.org/10.1111/j.1365-2133.2005.06554.x
- Fu, Y., Karbaat, L., Wu, L., et al. (2017) Trophic Effects of Mesenchymal Stem Cells in Tissue Regeneration. Tissue Engineering Part B: Reviews, 23, 515-528. https://doi.org/10.1089/ten.teb.2016.0365
- Bhargava, S., Cunha, P.R., Lee, J., et al. (2018) Acne Scarring Management: Systematic Review and Evaluation of the Evidence. American Journal of Clinical Dermatology, 19, 459-477. https://doi.org/10.1007/s40257-018-0358-5
- Thiboutot, D.M., Dreno, B., Abanmi, A., et al. (2018) Practical Management of Acne for Clinicians: An International Consensus from the Global Alliance to Improve Outcomes in Acne. Journal of the American Academy of Dermatology, 78, S1-S23e1. https://doi.org/10.1016/j.jaad.2017.09.078
- Ibrahim, Z.A., Eltatawy, R.A., Ghaly, N.R., et al. (2015) Autologus Bone Marrow Stem Cells in Atrophic Acne Scars: A Pilot Study. Journal of Dermatological Treatment, 26, 260-265. https://doi.org/10.3109/09546634.2014.946379
- Neri, S. (2019) Genetic Stability of Mesenchymal Stromal Cells for Regenerative Medicine Applications: A Fundamental Biosafety Aspect. International Journal of Molecular Sciences, 20, pii: E2406. https://doi.org/10.3390/ijms20102406
- Togashi, S., Takahashi, N., Iwama, M., et al. (2002) Antioxidative Collagen-Derived Peptides in Human-Placenta Extract. Placenta, 23, 497-502. https://doi.org/10.1053/plac.2002.0833