Effect of a Cosmetic Use with 2% Isostearyl-L-Ascorbic Acid Gel for Postinflammatory Hyperpigmentation and Postinflammatory Erythema in Acne Vulgaris
- 1 Department of Dermatology, Meiwa Hospital, Nishinomiya, Hyogo, Japan
- 2 Kobayashi Skin Clinic, Kobe, Japan
- 3 Hayashibe Skin Clinic, Sanda, Japan
Abstract
Postinflammatory hyperpigmentation (PIH) and postinflammatory erythema (PIE) in acne vulgaris are important and refractory complications for patients with acne vulgaris. To clarify the effects of 2% isostearyl-L-ascorbic acid (ISAA) against PIH and PIE in acne vulgaris, a clinical pilot study with topical 2% ISAA gel was performed in 25 acne patients with PIH and PIE. Topical ISAA gel was applied on the whole face with PIH and PIE in acne vulgaris twice a day for 3 months. Regarding PIH and PIE, investigator’s global improvement rating (IGIR) was evaluated in 7-point scales according to the reduced area of PIH and PIE before and after the study. Remarkable improvement in PIH was observed in 7 patients (28.0%) and in PIE in 12 (48%) of the 25 patients. No adverse reactions were observed during the treatment. Topical ISAA application can be an alternative, non-invasive available treatment for PIH and PIE in acne vulgaris.
- Hayashi, N., Akamatsu, H., Iwatsuki, K., et al. (2018) Japanese Dermatological Association Guidelines: Guidelines for the Treatment of Acne Vulgaris 2017. The Journal of Dermatology, 45, 898-935. https://doi.org/10.1111/1346-8138.14355
- Kurokawa, I., Oiso, N. and Kawada, A. (2017) Adjuvant Alternative Treatment with Chemical Peeling and Subsequent Iontophoresis for Postinflammatory Hyperpigmentation, Erosion with Inflamed Red Papules and Non-Inflamed Atrophic Scars in Acne Vulgaris. The Journal of Dermatology, 44, 401-405. https://doi.org/10.1111/1346-8138.13634
- Shibayama, H., Hisama, M., Matsuda, S. and Ohtsuki, M. (2008) Permeation and Metabolism of a Novel Ascorbic Acid Derivative, Disodium Isostearyl 2-L-Ascorbyl Phosphate, in Human Living Skin Equivalent Model. Skin Pharmacology and Physiology, 21, 235-248. https://doi.org/10.1159/000139128
- Matsuda, S., Shibayama, H., Hisama, M., Ohtsuki, M. and Iwaki, M. (2008) Inhibitory Effects of a Novel Ascorbic Derivative, Disodium Isostearyl 2-O-L-Ascorbyl Phosphate on Melanogenesis. Chemical and Pharmaceutical Bulletin, 56, 292-297. https://doi.org/10.1248/cpb.56.292
- Mohammed, B.M., Fisher, B.J., Kraskauskas, D., et al. (2016) Vitamin C Promotes Wound Healing through Novel Pleiotropic Mechanisms. International Wound Journal., 13, 572-584. https://doi.org/10.1111/iwj.12484
- Inui, S. and Itami, S. (2007) Perifollicular Pigmentation Is the First Target for Topical Vitamin C Derivative Ascorbyl 2-Phosphate 6-Palmitate (APPS): Randomized, Single-Blinded, Placebo-Controlled Study. The Journal of Dermatology, 34, 221-223. https://doi.org/10.1111/j.1346-8138.2007.00256.x