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Reaction Rate Models for the Thermal Decomposition of Ibuprofen Crystals
Department of Physics, Thiruvalluvar College, Papanasam, India
Department of Physics, Thiruvalluvar College, Papanasam, India
- 1 Department of Physics, Thiruvalluvar College, Papanasam, India
- 2 Department of Physics, Thiruvalluvar College, Papanasam, India
Journal of Crystallization Process and Technology·Volume 04 (2014)·Pages 71–78·Published 3 April 2014·DOI10.4236/jcpt.2014.42010
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Abstract
Kinetics of the decomposition of racemic ibuprofen crystals were studied by non-isothermal analysis. Thermogravimetric analysis revealed that ibuprofen is thermally stable up to 152.6°C and the initial loss of mass was due to evaporation only. Activation energy, pre-exponential factor, activation entropy and Gibbs free energy for the decomposition of ibuprofen were determined using the integral method of Coats-Redfern (CR). Geometrical contraction models were found to be the best fits. The Arrheinus equation for the thermal decomposition of ibuprofen is k = (1.1 × 10 7 ) e –79125/RT sec –1 .
KeywordsIbuprofenModel FittingKineticsDecompositionCoats-Redfern Method
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