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Synthesis and X-Ray Structure of New Anticancer Nucleosides Based on 1-((2-Hydroxyethoxy)methyl)-5-(phenylthio)-1H-1,2,4-triazole-3-carboxamide
College of Chemistry and Chemical Engineering & Hubei Key Laboratory of Pollutant Analysis & Reuse Technology, Hubei Normal University, Huangshi, China
College of Chemistry and Chemical Engineering & Hubei Key Laboratory of Pollutant Analysis & Reuse Technology, Hubei Normal University, Huangshi, China
School of Chemistry & Environmental Science, Shaanxi University of Technology, Hanzhong, China
School of Chemistry & Environmental Science, Shaanxi University of Technology, Hanzhong, China
School of Chemistry & Environmental Science, Shaanxi University of Technology, Hanzhong, China
- 1 College of Chemistry and Chemical Engineering & Hubei Key Laboratory of Pollutant Analysis & Reuse Technology, Hubei Normal University, Huangshi, China
- 2 College of Chemistry and Chemical Engineering & Hubei Key Laboratory of Pollutant Analysis & Reuse Technology, Hubei Normal University, Huangshi, China
- 3 School of Chemistry & Environmental Science, Shaanxi University of Technology, Hanzhong, China
- 4 School of Chemistry & Environmental Science, Shaanxi University of Technology, Hanzhong, China
- 5 School of Chemistry & Environmental Science, Shaanxi University of Technology, Hanzhong, China
Journal of Crystallization Process and Technology·Volume 04 (2014)·Pages 135–139·Published 23 June 2014·DOI10.4236/jcpt.2014.43017
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Abstract
A pair of new anticancer nucleosides based on 1,2,4-triazole nucleosides and 1-((2-hydroxyethoxy) methyl)-5-(phenylthio)-1H-1,2,4-triazole-3-carboxamide have been synthesized, and have given the corresponding products in excellent yields. Its structures and conformations were confirmed by single crystal X-ray diffraction.
KeywordsAnticancer NucleosidesTriazole NucleosidesExcellent Yields
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