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Synthesis and X-Ray Structure of Important Anticancer Nucleosides Intermediate (2<i>R</i>,3<i>S</i>,4<i>S</i>,5<i>R</i>)-2-(acetoxymethyl)-5- (3-bromo-5-(methoxycarbonyl)- 1<i>H</i>-1,2,4-triazol-1-yl)tetrahydrofuran- 3,4-diyl Diacetate
School of Chemistry and Environmental Science, Shaanxi University of Technology, Hanzhong, China
School of Chemistry and Environmental Science, Shaanxi University of Technology, Hanzhong, China
School of Chemistry and Environmental Science, Shaanxi University of Technology, Hanzhong, China
School of Chemistry and Environmental Science, Shaanxi University of Technology, Hanzhong, China
School of Chemistry and Environmental Science, Shaanxi University of Technology, Hanzhong, China
Department of Chemistry and Environmental Engineering, Hubei Normal University, Huangshi, China
- 1 School of Chemistry and Environmental Science, Shaanxi University of Technology, Hanzhong, China
- 2 School of Chemistry and Environmental Science, Shaanxi University of Technology, Hanzhong, China
- 3 School of Chemistry and Environmental Science, Shaanxi University of Technology, Hanzhong, China
- 4 School of Chemistry and Environmental Science, Shaanxi University of Technology, Hanzhong, China
- 5 School of Chemistry and Environmental Science, Shaanxi University of Technology, Hanzhong, China
- 6 Department of Chemistry and Environmental Engineering, Hubei Normal University, Huangshi, China
Journal of Crystallization Process and Technology·Volume 04 (2014)·Pages 140–144·Published 23 June 2014·DOI10.4236/jcpt.2014.43018
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Abstract
An important anticancer nucleosides intermediate ( 2 R ,3 S ,4 S ,5 R )-2-(acetoxymethyl)-5-(3-bromo-5-(methoxycar-bonyl)-1 H -1,2,4-triazol-1-yl)tetrahydrofuran-3,4-diyl diacetate was synthesized by directly coupling the bromotriazole with the protected ribose sugar, and have given the corresponding product in moderate yield. Its structure and conformation were confirmed by single crystal X-ray diffraction.
KeywordsAnticancer NucleosidesIntermediateTriazole Nucleosides
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