Research ArticleOpen AccessGoogle Scholar indexed
Crystal Type Iof Azilsartan Polymorphs: Preparation and Analysis
School of Chemistry and Chemical Engineering, Southeast University, Nanjing, China
School of Chemistry and Chemical Engineering, Southeast University, Nanjing, China
School of Chemistry and Chemical Engineering, Southeast University, Nanjing, China
- 1 School of Chemistry and Chemical Engineering, Southeast University, Nanjing, China
- 2 School of Chemistry and Chemical Engineering, Southeast University, Nanjing, China
- 3 School of Chemistry and Chemical Engineering, Southeast University, Nanjing, China
Journal of Crystallization Process and Technology·Volume 06 (2016)·Pages 1–10·Published 28 January 2016·DOI10.4236/jcpt.2016.61001
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Abstract
Azilsartan (2-ethoxy-1-([2’-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl)-1H-benzimidazole-7-carboxylic acid) is a new angiotensin II receptor antagonist used in the treatment of hypertension. This paper describes the preparation of type I crystal and its single crystal diffraction data, the comparison of the powder diffraction data for both type I and II crystals as well as their stability and solubility in methanol.
KeywordsAzilsartanSingle Crystal DiffractionPowder DiffractionSolubilityStability
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