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The Role of HER2/Neu and BRCA1 Genes in the Diagnosis of Breast Cancer among Sudanese Women
Department of Histopathology and Cytology, Faculty of Medical Laboratory Science, Al-Neelain University, Khartoum, Sudan
Department of Histology, College of Medicine, Alrayan Colleges, Almadinah Almunawwarah, KSA
Department of Biochemistry, Faculty of Medicine, Umm Al-Qura University, Makkah, KSA
Department of Basic Medical Science, Faculty of Medicine, Alrayan Colleges, Almadinah Almunawarah, KSA
Department of Anatomy and Histology, Faculty of Medicine, Batterjee Medical College, Jeddah, KSA
Department of Biochemistry and Molecular Biology, Faculty of Science and Technology, Al-Neelain University, Khartoum, Sudan
- 1 Department of Histopathology and Cytology, Faculty of Medical Laboratory Science, Al-Neelain University, Khartoum, Sudan
- 2 Department of Histology, College of Medicine, Alrayan Colleges, Almadinah Almunawwarah, KSA
- 3 Department of Biochemistry, Faculty of Medicine, Umm Al-Qura University, Makkah, KSA
- 4 Department of Basic Medical Science, Faculty of Medicine, Alrayan Colleges, Almadinah Almunawarah, KSA
- 5 Department of Anatomy and Histology, Faculty of Medicine, Batterjee Medical College, Jeddah, KSA
- 6 Department of Biochemistry and Molecular Biology, Faculty of Science and Technology, Al-Neelain University, Khartoum, Sudan
Journal of Cancer Therapy·Volume 11 (2020)·Pages 491–496·Published 17 August 2020·DOI10.4236/jct.2020.118042
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Abstract
Background : Knowledge of HER2/Neu and BRCA1 Genes might be helpful for development of strategies for decreasing the burden of risk of breast cancer. Therefore, the aim of this study to detect the role of HER2/Neu and BRCA1 Genes expression in diagnosis of breast cancer in Sudanese women. Methodology : A total of 100 tissue samples obtained from patients with breast cancer in addition to 50 tissue samples obtained from patients with benign breast lesions, were detected the expression of HER2/Neu and BRCA1 Genes by Polymerase Chain Reaction (PCR). Results: The prevalence of HER2/Neu and BRCA1 Genes, among cases was 6%, and 10% respectively . Conclusion: HER2/Neu and BRCA1 Genes have a considerable contribution to etiology of breast cancer in Sudan that requires further consideration.
KeywordsHER2/Neu and BRCA1 GenesBreast CancerSudan
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