Evaluation of Ovarian Cancer Care at the End of Life in a Single Tertiary Hospital
- 1 Department of Gynecology and Obstetrics, Kuopio University Hospital, Kuopio, Finland
- 2 Department of Health Sciences, Clinical Medicine, University of Eastern Finland, Kuopio, Finland
- 3 Department of Health Sciences, Clinical Medicine, University of Eastern Finland, Kuopio, Finland
- 4 Department of Gynecology and Obstetrics, Kuopio University Hospital, Kuopio, Finland
Abstract
Aim : Fundamentally, aggressive care is considered to be avoided for the patients at the end of life. However, this is not always adhered in real-world practice. We attempted to determine whether, and if so how, the aggressive care is made for patients with ovarian cancer during the last month prior death. Methods : Enrolled were a total of 104 patients with ovarian cancer (including fallopian tube or primary peritoneal cancer), who were treated in Kuopio University Hospital in Finland during 2009-2014. The aggressive care was defined according to the standards outlined by the National Quality Forum; shortly, chemotherapy, emergency-room/intensive-care visit/admission, hospital admission, and death in hospital. Results : Two thirds of patients (67%) had received at least one form of aggressive care during the last month of their lives. Especially, admission in hospital in the last 30 days of life was the most common form of aggressive cancer care. Younger patients (<72 years) received significantly more often aggressive care than the older patients (80% vs 43%, p = 0.004). Those women that underwent end-of-life discussions earlier than one month prior to death had significantly less aggressive care than those women that had discussions during the last month (48% vs. 90%, p = 0.001). Conclusions : Ovarian cancer patients received commonly at least one form of aggressive care at the end of their lives. More efforts should be taken to improve the quality of palliative and end-of-life care.
- Oberaigner, W., Minicozzi, P., Bielska-Lasota, M., Allemani, C., de Angelis, R., Mangone, L., et al. (2012) Survival for Ovarian Cancer in Europe: The Across-Country Variation Did Not Shrink in the Past Decade. Acta Oncologica, 51, 441-453. https://doi.org/10.3109/0284186X.2011.653437
- du Bois, A., Luck, H.J., Meier, W., Adams, H.P., Mobus, V., Costa, S., et al. (2003) A Randomized Clinical Trial of Cisplatin/Paclitaxel versus Carboplatin/Paclitaxel as First-Line Treatment of Ovarian Cancer. Journal of the National Cancer Institute, 95, 1320-1329. https://doi.org/10.1093/jnci/djg036
- Agarwal, R. and Kaye, S.B. (2003) Ovarian Cancer: Strategies for Overcoming Resistance to Chemotherapy. Nature Reviews Cancer, 3, 502-516. https://doi.org/10.1038/nrc1123
- Eng, K.H., Hanlon, B.M., Bradley, W.H. and Szender, J.B. (2015) Prognostic Factors Modifying the Treatment-Free Interval in Recurrent Ovarian Cancer. Gynecologic Oncology, 139, 228-235. https://doi.org/10.1016/j.ygyno.2015.09.011
- Friedlander, L.M., Stockler, T.M., O’connell, T.R., Voysey, T.M., Oza, T.A., Gillies, T.K., et al. (2014) Symptom Burden and Outcomes of Patients with Platinum Resistant/Refractory Recurrent Ovarian Cancer: A Reality Check: Results of Stage 1 of the Gynecologic Cancer Intergroup Symptom Benefit Study. International Journal of Gynecological Cancer, 24, 857-864. https://doi.org/10.1097/IGC.0000000000000147
- Anonymous National Voluntary Consensus Standards for Quality of Cancer Care. http://www.qualityforum.org/Publications/2009/05/National_Voluntary_Consensus_Standards_ for_Quality_of_Cancer_Care.aspx
- Earle, C.C., Landrum, M.B., Souza, J.M., Neville, B.A., Weeks, J.C. and Ayanian, J.Z. (2008) Aggressiveness of Cancer Care near the End of Life: Is It a Quality-of-Care Issue? Journal of Clinical Oncology, 26, 3860-3866. https://doi.org/10.1200/JCO.2007.15.8253
- Brown, A.J., Sun, C.C., Prescott, L.S., Taylor, J.S., Ramondetta, L.M. and Bodurka, D.C. (2014) Missed Opportunities: Patterns of Medical Care and Hospice Utilization among Ovarian Cancer Patients. Gynecologic Oncology, 135, 244-248. https://doi.org/10.1016/j.ygyno.2014.08.039
- Lopez-Acevedo, M., Havrilesky, L.J., Broadwater, G., Kamal, A.H., Abernethy, A.P., Berchuck, A., et al. (2013) Timing of End-of-Life Care Discussion with Performance on End-of-Life Quality Indicators in Ovarian Cancer. Gynecologic Oncology, 130, 156-161. https://doi.org/10.1016/j.ygyno.2013.04.010
- Temel, J.S., Greer, J., Muzikansky, A., Gallagher, E., Admane, S., Jackson, V., et al. (2010) Early Palliative Care for Patients with Metastatic Non-Small-Cell Lung Cancer. The New England Journal of Medicine, 363, 733. https://doi.org/10.1056/NEJMoa1000678