Expression of EMT-Related Factors in Intrahepatic Cholangiolithiasis Associated Cholangiocarcinoma and Its Clinical Significance — Oak Academic Publishing
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Expression of EMT-Related Factors in Intrahepatic Cholangiolithiasis Associated Cholangiocarcinoma and Its Clinical Significance
The Fourth People’s Hospital of Haikou, Haikou, China
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The Fourth People’s Hospital of Haikou, Haikou, China
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The Fourth People’s Hospital of Haikou, Haikou, China
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Hainan General Hospital, Haikou, China
1 The Fourth People’s Hospital of Haikou, Haikou, China
2 The Fourth People’s Hospital of Haikou, Haikou, China
3 The Fourth People’s Hospital of Haikou, Haikou, China
In this study, tumor microenvironment and related pathways play an important role in the EMT process of bile duct tumors to analyze the role of EMT in the occurrence and development of cholangiolithiasis associated bile duct carcinoma and investigate the expression of EMT in intrahepatic cholangiolithiasis associated cholangiocarcinoma and its clinical significance.
KeywordsEMTThe LiverCancerOrganization
Thiery, J.P., Acloque, H., Huang, R.Y., et al. (2009) Epithelial-Mesenchymal Transitions in Development and Disease. Cell, 139, 871-890. https://doi.org/10.1016/j.cell.2009.11.007
Wu, Y. and Zhou, B.P. (2008) New Insights of Epithelial-Mesenchymal Transition in Cancer Metastasis. Acta Biochimica et Biophysica Sinica (Shanghai), 40, 643-650. https://doi.org/10.1111/j.1745-7270.2008.00443.x
Moustakas, A. and Heldin, C.H. (2007) Signaling Networks Guiding Epithelial-Mesenchymal Transitions during Embryogenesis and Cancer Progression. Cancer Science, 98, 1512-1520. https://doi.org/10.1111/j.1349-7006.2007.00550.x
Lee, B.S., Park, E.C., Park, S.W., et al. (2015) Hepatitis B Virus Infection, Diabetes Mellitus, and Their Synergism for Cholangiocarcinoma Development: A Case-Control Study in Korea. World Journal of Gastroenterology, 21, 502-510. https://doi.org/10.3748/wjg.v21.i2.502
Chaffer, C.L., Thompson, E.W. and Williams, E.D. (2007) Mesenchymal to Epithelial Transition in Development and Disease. Cells Tissues Organs, 185, 7-19. https://doi.org/10.1159/000101298
Geiger, T.R. and Peeper, D.S. (2009) Metastasis Mechanisms. Biochimica et Biophysica Acta, 1796, 293-308. https://doi.org/10.1016/j.bbcan.2009.07.006
Guglielmi, A., Ruzzenente, A., Valdegamberi, A., et al. (2014) Hepatolithiasis-Associated Cholangiocarcinoma: Results from a Multi-Institutional National Database on a Case Series of 23 Patients. European Journal of Surgical Oncology, 40, 567-575. https://doi.org/10.1016/j.ejso.2013.12.006
Dowling, P., Walsh, N. and Clynes, M. (2008) Membrane and Membrane-Associated Proteins Involved in the Aggressive Phenotype Displayed by Highly Invasive Cancer Cells. Proteomics, 8, 4054-4065. https://doi.org/10.1002/pmic.200800098
Chenette, E.J. (2009) Cancer: A Ras and NF-kappaB pas de deux. Nature Reviews Drug Discovery, 8, 932. https://doi.org/10.1038/nrd3060
Restucci, B., Martano, M., et al. (2009) Expression of E-cadherin, beta-catenin and APC Protein in Canine Colorectal Tumours. Anticancer Research, 29, 2919-2925.
Bourguignon, L.Y., Peyrollier, K., Xia, W., et al. (2008) Hyaluronan-CD44 Interaction Activates Stem Cell Marker Nanog, Stat-3-Mediated MDR1 Gene Expression, and Ankyrin-Regulated Multidrug Efflux in Breast and Ovarian Tumor Cells. Journal of Biological Chemistry, 283, 17635-17651. https://doi.org/10.1074/jbc.M800109200
Jemal, A., Bray, F., Center, M.M., et al. (2011) Global Cancer Statistics. CA: A Cancer Journal for Clinicians, 61, 69-90. https://doi.org/10.3322/caac.20107
Rhim, A.D., Mirek, E.T., Aiello, N.M., et al. (2012) EMT and Dissemination Precede Pancreatic Tumor Formation. Cell, 148, 349-361. https://doi.org/10.1016/j.cell.2011.11.025
Trujillo, K.A., Heaphy, C.M., Mai, M., et al. (2011) Markers of Fibrosis and Epithelial to Mesenchymal Transition Demonstrate Field Cancerization in Histologically Normal Tissue Adjacent to Breast Tumors. International Journal of Cancer, 129, 1310-1321. https://doi.org/10.1002/ijc.25788
Araki, K., Shimura, T., Suzuki, H., et al. (2011) E/N-Cadhefin Switch Mediates Cancer Progression via TGF-Beta-Induced Epithelial-to-Mesenchymal Transition in Extrahepatic Cholangiocarcinoma. British Journal of Cancer, 105, 1885-1893. https://doi.org/10.1038/bjc.2011.452
Nitta, T., Mitsuhashi, T., Hatanaka, Y., et al. (2014) Prognostic Significance of Epithelial-Mesenchymal Transition-Related Markers in Extrahepatic Cholangiocarcinoma: Comprehensive Immunohistochemical Study Using a Tissue Microarray. British Journal of Cancer, 111, 1363-1372. https://doi.org/10.1038/bjc.2014.415
Shuang, Z.Y., Wu, W.C., Xu, J., et al. (2014) Transforming Growth Factor-Betal-Induced Epithelial-Mesenchymal Transition Generates ALDH-Positive Cells with Stem Cell Properties in Cholangiocarcinoma. Cancer Letters, 354, 320-328. https://doi.org/10.1016/j.canlet.2014.08.030
Willis, B.C. and Borok, Z. (2007) TGF-Beta-Induced EMT: Mechanisms and Implications for Fibrotic Lung Disease. American Journal of Physiology-Lung Cellular and Molecular Physiology, 293, L525-L534. https://doi.org/10.1152/ajplung.00163.2007
Acloque, H., Adams, M.S., Fishwick, K., et al. (2009) Epithelial-Mesenchymal Transitions: The Importance of Changing Cell State in Development and Disease. Journal of Clinical Investigation, 119, 1438-1449. https://doi.org/10.1172/JCI38019
Chen, W., Liang, J., Huang, L., Huang, L., Cai, J., et al. (2016) Characterizing the Activation of the Wnt Signaling Pathway in Hilar Cholangiocarcinoma Using a Tissue Microarray Approach. European Journal of Histochemistry, 60, 2536. https://doi.org/10.4081/ejh.2016.2536
Boulter, L., Guest, R.V., Guest, R.V., Kendall, T.J., Kendall, T.J., Wilson, D.H., et al. (2015) WNT Signaling Drives Cholangiocarcinoma Growth and Can Be Pharmacologically Inhibited. Journal of Clinical Investigation, 125, 1269-1285. https://doi.org/10.1172/JCI76452
Li, M. and Deng, F. (2015) The Role of miR-200c in Tumor Diagnosis, Metastasis and Drug Resistance. International Journal of Oncology, 42, 602-604.
Peinado, H. and Olmedad, C.A. (2007) Snail, ZEB and bHLH Factors in Tumour Progression: An Alliance against the Epithelial Phenotype? Nature Reviews Cancer, 7, 415-428. https://doi.org/10.1038/nrc2131
Bn, S. and Na, B. (2016) Role of EMT in Metastasis and Therapy Resistance. Journal of Clinical Medicine, 5, 17. https://doi.org/10.3390/jcm5020017
Claperon, A., Mergey, M., Bouldoires, T.H.N., et al. (2014) EGF/EGFR Axis Contributes to the Progression of Cholangiocarcinoma through the Induction of an Epithelial-Mesenchymal Transition. Journal of Hepatology, 61, 325-332. https://doi.org/10.1016/j.jhep.2014.03.033
Techasen, A., Loilome, W., et al. (2012) Cytokines Released from Activated Human Macrophages Induce Epithelial Mesenchymal Transition Markers of Cholangiocarcinoma Cells. Asian Pacific Journal of Cancer Prevention, 13, 115-118.
Okamoto, K., Tajima, H., Nakanuma, S., et al. (2012) Angiotensin II Enhances Epithelial-to-Mesenchymal Transition through the Interaction between Activated Hepatic Stellate Cells and the Stromal Cell-Derived Factor-1/CXCR4 Axis in Intrahepatic Cholangiocarcinoma. International Journal of Oncology, 41, 573-582. https://doi.org/10.3892/ijo.2012.1499
Zhao, Y.B., Wang, H.B., Li, X.L., et al. (2014) Ang II-AT1R Increases Cell Migration through P13K/AKT and NF-kappa B Pathways in Breast Cancer. Journal of Cellular Physiology, 229, 1855-1862. https://doi.org/10.1002/jcp.24639
Kurashige, J., Mima, K., Sawada, G., et al. (2015) Epigenetic Modulation and Repression of miR-200b by Cancer-Associated Fibroblasts Contribute to Cancer Invasion and Peritoneal Dissemination in Gastric Cancer. Carcinogenesis, 36, 133-141. https://doi.org/10.1093/carcin/bgu232
Zhou, C., Zheng, Y., Li, L., et al. (2015) Adrenomedullin Promotes Intrahepatic Cholangiocellular Carcinoma Metastasis and Invasion by Inducing Epithelial Mesenchymal Transition. Ontology Reports, 34, 610-616. https://doi.org/10.3892/or.2015.4034
Zhu, T.C., Yang, J., Liu, X.O., et al. (2015) Hypoxia-Inducible Adrenomedullin Ameliorates the Epithelial-to-Mesenchymal Transition in Human Proximal Tubular Epithelial Cells. Molecular Medicine Reports, 11, 3760-3766. https://doi.org/10.3892/mmr.2015.3189
Zhang, M.N., Tang, Z.J. and Chen, L. (2014) The Role of Autophagy-Apoptosis Pathway in Tumor Targeted Therapy. Journal of Oncology, 5, 413-418.
Catalano, M., D’alessandro, G., Lepore, F., et al. (2015) Autophagy Induction Impairs Migration and Invasion by Reversing EMT in Glioblastoma Cells. Molecular Oncology, 9, 1612-1625. https://doi.org/10.1016/j.molonc.2015.04.016
Nitta, T., Sato, Y., Ren, X.S., et al. (2014) Autophagy May Promote Carcinoma Cell Invasion and Correlate with Poor Prognosis in Cholangiocarcinoma. International Journal of Clinical and Experimental Pathology, 7, 4913-4921.
Wu, Z.F., Yang, N., Li, D.Y., et al. (2013) Characteristics of Intrahepatic Cholangiocarcinoma in Patients with Hepatitis B Virus Infection: Clinicopathologic Study of Resected Tumours . Journal of Viral Hepatitis, 20, 306-316. https://doi.org/10.1111/jvh.12005
Su, X.C., Pang, S.J., Yang, N., et al. (2015) Clinical Characteristics and Prognosis of Intrahepatic Cholangiocellular Carcinoma Associated with Intrahepatic Cholangiolithiasis. Journal of Jiangsu University: Medical Science, N. 3, 241-246.
Shimada, K., Sano, T., Sakamoto, Y., et al. (2007) Outcomes of the Mass-Forming plus Periductal Infiltrating Types of Intrahepatic Cholangiocarcinoma: A Comparative Study with the Typical Mass-Forming Type of Intrahepatic Cholangiocarcinoma. World Journal of Surgery, 31, 2016-2022. https://doi.org/10.1007/s00268-007-9194-0
Xu, J., Sasaki, M., Harada, K., et al. (2011) Intrahepatic Cholangiocarcinoma Arising in Chronic Advanced Liver Disease and the Cholangiocarcinomatous Component of Hepatocellular Cholangiocarcinoma Share Common Phenotypes and Cholangiocarcinogenesis. Histopathology, 59, 1090-1099. https://doi.org/10.1111/j.1365-2559.2011.04058.x
Aishima, S., Kuroda, Y., Nishihara, Y., et al. (2007) Proposal of Progression Model for Intrahepatic Cholangiocarcinoma: Clinicopathologic Differences between Hilar Type and Peripheral Type. American Journal of Surgical Pathology, 31, 1059-1126. https://doi.org/10.1097/PAS.0b013e31802b34b6
Nakanuma, Y., Miyata, T. and Uchida, T. (2016) Latest Advances in the Pathological Understanding of Cholangiocarcinomas. Expert Review of Gastroenterology & Hepatology, 10, 113-140. https://doi.org/10.1586/17474124.2016.1104246