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Multi-Metastatic Hepatoid Adenocarcinoma of the Lung: Report of Case
Department of Oncology, University Hospital Tanambao Antsiranana, Antananarivo, Madagascar
Department of Radiology, University Hospital Place Kabary Antsiranana, Antananarivo, Madagascar
Department of Radiotherapy, University Hospital Joseph Ravoahangy Andrianavalona, Antananarivo, Madagascar
Department of Radiology, University Hospital Joseph Ravoahangy Andrianavalona, Antananarivo, Madagascar
Department of Anatomy Pathology, Institut Pasteur of Madagascar, Antananarivo, Madagascar
Department of Radiotherapy, University Hospital Joseph Ravoahangy Andrianavalona, Antananarivo, Madagascar
- 1 Department of Oncology, University Hospital Tanambao Antsiranana, Antananarivo, Madagascar
- 2 Department of Radiology, University Hospital Place Kabary Antsiranana, Antananarivo, Madagascar
- 3 Department of Radiotherapy, University Hospital Joseph Ravoahangy Andrianavalona, Antananarivo, Madagascar
- 4 Department of Radiology, University Hospital Joseph Ravoahangy Andrianavalona, Antananarivo, Madagascar
- 5 Department of Anatomy Pathology, Institut Pasteur of Madagascar, Antananarivo, Madagascar
- 6 Department of Radiotherapy, University Hospital Joseph Ravoahangy Andrianavalona, Antananarivo, Madagascar
Journal of Cancer Therapy·Volume 13 (2022)·Pages 304–309·Published 11 May 2022·DOI10.4236/jct.2022.135026
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Abstract
Hepatoid adenocarcinoma of the lung is a rare tumor with a poor prognosis. There are no specific treatment-recommendations for this cancer. We report a 59-year-old man, a former smoker, with this condition. He presented with a cough and computed tomography revealed a pulmonary nodule (50 × 47 × 48 mm) with a right pleural effusion, together with a cerebral right temporal-lobe lesion and a right adrenal lesion. The serum alpha-fetoprotein value was normal. Histological examination via bronchoscopic biopsy revealed an adenocarcinoma. Positive CK7, AE1/AE2 , and TTF1 with granular cytoplasmic staining on immunohistochemical study confirmed the diagnosis of hepatoid adenocarcinoma of the lung, stage IV-B. The patient had received chemotherapies (carboplatin-pemetrexed, gemcitabine) and cerebral radiotherapy, but he died at eight months of the treatment as a result of tumor progression .
KeywordsHepatoid AdenocarcinomaLungChemothérapyMetastasis
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