Association Study of Thyroid Papillary Carcinoma with Depression and BDNF Expression

Abstract

Objective: To analyze the correlation between Val66Met gene of brain - derived neurotrophic factor (BDNF) and papillary thyroid carcinoma (PTC) complicated with depression. To evaluate the clinical value of papillary thyroid carcinoma. Methods: Self-rating Anxiety Scale (SAS) and Self-rating Depression Scale (SDS) were used to assess the correlation of BDNF in the blood of patients with depressive disorder of thyroid papillary carcinoma using polymerase chain reaction PCR. The relationship between BDNF gene polymorphism and the incidence of thyroid papillary carcinoma was analyzed, and the susceptibility factors of thyroid papillary carcinoma complicated with depression were explored. Results: Compared with normal control group, T3 and T4 of PTC in non-depressed group were decreased, while TSH and TPOAb were increased (P < 0.05). Compared with normal control group, T3, T4 and TPOAb were increased and TSH was decreased in PTC depression group (P < 0.05). PTC depression score was higher than that of healthy control group (P < 0.05), and PTC combined depression score was higher than that of normal control group (P < 0.05). The depression rate of PTC combined with depression was 86.7%, which was higher than that of other groups (P < 0.05). The distribution of RS6265 locus genotype of BDNF gene was significantly different between PTC with depression group and PTC without depression group (P < 0.05). Conclusion: There is a significant difference between PTC with depression and PTC without depression, which is related to SNP rs6265 of BDNF gene. AG and GG are both risk sites of PTC with depression, and GG type is more prone to PTC with depression.