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Pre- and Post-Surgical Health-Related Quality of Life Evaluation of Esophageal Carcinoma Patients
Department of Thoracic Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China
Department of Thoracic Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China
Department of Thoracic Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China
Department of Thoracic Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China
Department of Thoracic Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China
Department of Thoracic Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China
Department of Thoracic Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China
Department of Thoracic Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China
- 1 Department of Thoracic Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China
- 2 Department of Thoracic Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China
- 3 Department of Thoracic Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China
- 4 Department of Thoracic Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China
- 5 Department of Thoracic Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China
- 6 Department of Thoracic Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China
- 7 Department of Thoracic Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China
- 8 Department of Thoracic Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China
Journal of Cancer Therapy·Volume 13 (2022)·Pages 585–597·Published 29 August 2022·DOI10.4236/jct.2022.139051
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Abstract
For patients with esophageal carcinoma (ESCA), health-related quality of life (HRQoL) has now become an essential feature. To examine the quality of life of preoperative and postoperative ESCA patients, we used the European Organization for Research and Treatment of Cancer Quality of Life Core Questionnaire (EORTC QLQ C-30) and the Quality of Life Questionnaire Oesophageal 18 (QLQ-OES18). Using the EORTC QLQ-C30 and the QLQ-OES18 questionnaire, t he analysis of the quality of life scores of 246 patients with oesophageal cancer who were operated on at the Sun Yat-sen Universit y Cancer Centre during the period 2013 to 2015 was carried out. Differences between pre- and post-surgical EORTC QLQ C-30 and QLQ-OES18 scores were examined using the Student’s t-test. Patients’ global health status (QoL) decr eased significantly one month after the operation but gradually recov ered within a year. In terms of the role function, the emotional function, the cognitive function, and the perception and function variants, EORTC QLQ-C30 and QLQ-OES18 scores increased statistically significantly, as did clinical signs variables such as exhaustion, nausea, vomiting, pain, sleeplessness, decreased appetite, stomach pain, and economic hardship. After surgery, there was a n improvement in functional and symptom domains in esophageal carcinoma patients. EORTC QLQ-C30 and QLQ-OES18 can be used to assess the HRQoL before and after surgical procedures.
KeywordsEsophageal CarcinomaEORTC QLQ C-30QLQ-OES18SurgeryQuality of Life
- Smyth, E.C., Lagergren, J., Fitzgerald, R.C., Lordick, F., Shah, M.A., Lagergren, P. and Cunningham, D. (2017) Oesophageal Cancer. Nature Reviews Disease Primers, 3, Article No. 17048. https://doi.org/10.1038/nrdp.2017.48
- Fitzmaurice, C., Abate, D., Abbasi, N., Abbastabar, H., Abd-Allah, F., Abdel-Rahman, O., et al. (2019) Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2017: A Systematic Analysis for the Global Burden of Disease Study. JAMA Oncology, 5, 1749-1768. https://doi.org/10.1001/jamaoncol.2019.2996
- Tachimori, Y., Ozawa, S., Numasaki, H., Matsubara, H., M Shinoda., Toh, Y., Udagawa, H., Fujishiro, M., Oyama, T. and Uno, T. (2016) Efficacy of Lymph Node Dissection by Node Zones According to Tumor Location for Esophageal Squamous Cell Carcinoma. Esophagus-Tokyo, 13, 1-7. https://doi.org/10.1007/s10388-015-0515-3
- A Herskovic., Martz, K., Al-Sarraf, M., Leichman, L., Brindle, J., Vaitkevicius, V., Cooper, J., Byhardt, R., Davis, L. and Emami, B. (1992) Combined Chemotherapy and Radiotherapy Compared with Radiotherapy alone in Patients with Cancer of the Esophagus. New England Journal of Medicine, 326, 1593-1598. https://doi.org/10.1056/NEJM199206113262403
- Borggreve, A.S., Kingma, B.F., Domrachev, S.A., Koshkin, M.A., Ruurda, J.P., van Hillegersberg, R., Takeda, F.R. and Goense, L. (2018) Surgical Treatment of Esophageal Cancer in the Era of Multimodality Management. Annals of the New York Academy of Sciences, 1434, 192-209. https://doi.org/10.1111/nyas.13677
- Lagergren, P., Avery, K.N., Hughes, R., Barham, C.P., Alderson, D., Falk, S.J. and Blazeby, J.M. (2007) Health-Related Quality of Life among Patients Cured by Surgery for Esophageal Cancer. Cancer, 110, 686-693. https://doi.org/10.1002/cncr.22833
- Rutegard, M., Lagergren, J., Rouvelas, I., Lindblad, M., Blazeby, J.M. and Lagergren, P. (2008) Population-Based Study of Surgical Factors in Relation to Health-Related Quality of Life after Oesophageal Cancer Resection. British Journal of Surgery, 95, 592-601. https://doi.org/10.1002/bjs.6021
- Schandl, A., Lagergren, J., Johar, A. and Lagergren, P. (2016) Health-Related Quality of Life 10 Years after Oesophageal Cancer Surgery. European Journal of Cancer, 69, pp. 43-50. https://doi.org/10.1016/j.ejca.2016.09.032
- Andre, T., Amonkar, M., Norquist, J.M., Shiu, K.K., Kim, T.W., Jensen, B.V., Jensen, L.H., Punt, C., Smith, D., Garcia-Carbonero, R., Sevilla, I., De La Fouchardiere, C., Rivera, F., Elez, E., Diaz, L.J., Yoshino, T., Van Cutsem, E., Yang, P., Farooqui, M. and Le, D.T. (2021) Health-Related Quality of Life in Patients with Microsatellite Instability-High or Mismatch Repair Deficient Metastatic Colorectal Cancer Treated with First-Line Pembrolizumab versus Chemotherapy (KEYNOTE-177): An Open-Label, Randomised, Phase 3 Trial. The Lancet Oncology, 22, 665-677. https://doi.org/10.1016/S1470-2045(21)00064-4