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5-Fluorouracil-Induced Hyperammonemia Encephalopathy in a Patient with Gastric Cancer
Department of Oncology, University Hospital Tanambao, Antsiranana, Madagascar
Department of Radiotherapy, University Hospital Joseph Ravoahangy Andrianavalona, Antananarivo, Madagascar
Department of Oncology, University Hospital Joseph Ravoahangy Andrianavalona, Antananarivo, Madagascar
Department of Radiotherapy, University Hospital Joseph Ravoahangy Andrianavalona, Antananarivo, Madagascar
Department of Radiotherapy, University Hospital Joseph Ravoahangy Andrianavalona, Antananarivo, Madagascar
- 1 Department of Oncology, University Hospital Tanambao, Antsiranana, Madagascar
- 2 Department of Radiotherapy, University Hospital Joseph Ravoahangy Andrianavalona, Antananarivo, Madagascar
- 3 Department of Oncology, University Hospital Joseph Ravoahangy Andrianavalona, Antananarivo, Madagascar
- 4 Department of Radiotherapy, University Hospital Joseph Ravoahangy Andrianavalona, Antananarivo, Madagascar
- 5 Department of Radiotherapy, University Hospital Joseph Ravoahangy Andrianavalona, Antananarivo, Madagascar
Journal of Cancer Therapy·Volume 14 (2023)·Pages 102–106·Published 27 February 2023·DOI10.4236/jct.2023.142009
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Abstract
Chemotherapy with 5-fluorouracil (5 FU) has been widely used to treat advanced gastric cancer. Knowing the side effects is therefore important in order to better prevent them. Fluoropyrimidine-induced hyperammonemic encephalopathy is a rare complication and characterized neurological status with elevated ammonia level without radiological abnormalities. We report the first case of 5 FU-induced hyperammonemic encephalopathy in women patient s on induction chemotherapy for gastric cancer in Madagascar. His ammonia level (NH 3 ) was 102 μmol/l. The patient recovered from his confusional state after two days of treatment with hyperhydration and vitamin therapy.
KeywordsEncephalopathyGastric CancerHyperammonemia5-Fluororuracil
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