Eyelid Kaposi Sarcoma in HIV-Negative Patient
- 1 Unit of Dermatology, University Hospital Center of Public Health and Care Analakely, Antananarivo, Madagascar
- 2 Unit of Radiotherapy, University Hospital Center Joseph Ravoahangy Andrianavalona, Antananarivo, Madagascar
- 3 Unit of Ophthalmology, University Hospital Center Joseph Ravoahangy Andrianavalona, Antananarivo, Madagascar
- 4 Unit of Dermatology, University Hospital Center of Public Health and Care Analakely, Antananarivo, Madagascar
- 5 Unit of Pathology, University Hospital Center Tambohobe, Fianarantsoa, Madagascar
- 6 Unit of Dermatology, University Hospital Center of Joseph Raseta Befelatanana, Antananarivo, Madagascar
- 7 Unit of Dermatology, University Hospital Center Morafeno, Toamasina, Madagascar
- 8 Unit of Ophthalmology, University Hospital Center Joseph Ravoahangy Andrianavalona, Antananarivo, Madagascar
- 9 Unit of Dermatology and Internal Medicine, University Hospital Center of Joseph Raseta Befelatanana, Antananarivo, Madagascar
- 10 Unit of Dermatology, University Hospital Center of Joseph Raseta Befelatanana, Antananarivo, Madagascar
Abstract
Introduction : Kaposi sarcoma disease is a proliferative and multifocal disorder with dual components, vascular and fibroblastic cellular, cutaneous and visceral expression. Kaposi Sarcoma can affect the ocular surface and adnexa and can masquerade as other entities, delaying prompt diagnosis can lead to diagnostic wandering delaying treatment. Our aim is to describe a case of KS of the eyelid in an HIV seronegative patient. Case Presentation : A seventy-year-old man developed a bilateral growing tumoral reddish purple vascular mass on both the lower and upper eyelid involving rapidly for 6 months. Both feet and the two shanks show the presence of a brown-violet tumor-shaped formation. The patient was negative for HIV. Histology examination showed a nodular tumor-like mass with a fibro hemangioma-epitheliomatous. Polymerase chain reaction was positive for human herpes virus 8. Initial chemotherapy fol lowed by surgery was proposed to the patient. Unfortunately, the patient rejected treatment and was lost to follow-up. Conclusion : This case reports the difficulty of managing KS in developing countries.
- National Comprehensive Cancer Network (2023) Kaposi Sarcoma Version 1.2024. https://www.nccn.org/professionals/physician_gls/pdf/kaposi.pdf
- Venkateswaran, N., Ramos, J.C., Cohen, A.K., Alvarez, O.P., Cohen, N.K. and Galor A. (2021) Spotlight on Ocular Kaposi’s Sarcoma: An Update on the Presentation, Diagnosis, and Management Options. Expert Review of Ophthalmology, 16, 477-489. https://doi.org/10.1080/17469899.2021.1962294
- Benajiba, L., Lambert, J., La Selva, R., Cochereau, D., Baroudjian, B. and Roux, J. (2021) Systemic Treatment Initiation in Classical and Endemic Kaposi’s Sarcoma: Risk Factors and Global Multi-State Modelling in a Monocentric Cohort Study. Cancers (Basel), 13, Article 2519. https://doi.org/10.3390/cancers13112519
- Hung, C.H., Kuo, H.W., Chiu, Y.K. and Huang, P.H. (2004) Intravascular Pyogenic Granuloma Arising in an Acquired Arteriovenous Malformation: Report of a Case and Review of the Literature. Dermatologic Surgery, 30, 1050-1053. https://doi.org/10.1097/00042728-200407000-00019
- Zarraga, M., Rosen, L. and Herschthal, D. (2011) Bacillary Angiomatosis in an Immunocompetent Child: A Case Report and Review of the Literature. The American Journal of Dermatopathology, 33, 513-515. https://doi.org/10.1097/DAD.0b013e3181ec846a
- Rasamoelina, T., Maubon, D., Andrianarison, M., Ranaivo, I., Sendrasoa, F. and Rakotozandrindrainy, N. (2020) Endemic Chromoblastomycosis Caused Predominantly by Fonsecaea nubica, Madagascar. Emerging Infectious Diseases, 26, 1201-1211. https://doi.org/10.3201/eid2606.191498
- Cinotti, E., Perrot, J.L., Tognetti, L. and Rubegni, P. (2021) Comments on Differentiating Basal Cell Carcinoma from Intradermal Nevi along the Eyelid Margin with Dermoscopy. Journal of the American Academy of Dermatology, 84, e303. https://doi.org/10.1016/j.jaad.2021.02.040
- Kohanim, S., Daniels, A.B., Huynh, N. and Chodosh, J. (2011) Local Treatment of Kaposi Sarcoma of the Conjunctiva. International Ophthalmology Clinics, 51, 183-192. https://doi.org/10.1097/IIO.0b013e31822d68e8
- Korn, B.S., Park, D.J.J. and Kikkawa, D.O. (2011) Intralesional Mitomycin-C for the Treatment of Conjunctival Kaposi Sarcoma. Ophthalmic Plastic & Reconstructive Surgery, 27, e88-90. https://doi.org/10.1097/IOP.0b013e3181ef72e7
- Gündüz, K., Günay, U., Inanir, I., Gençoğlan, G. and Temiz, P. (2012) Efficacy of 5% Imiquimod Cream in a Patient with Classic Kaposi Sarcoma. Journal of Dermatological Case Reports, 30, 52-53. https://doi.org/10.3315/jdcr.2012.1099