Research ArticleOpen AccessGoogle Scholar indexed
Transfusion of Ipscs-Derived Leukocytes to Kill Cancer
Department of Neurosurgery, Tang Du Hospital, The Fourth Military University, Xi’an, China
Department of Clinical Laboratory and Research center of Tang Du Hospital, The Forth Military Medical University; Xi’an, China
Department of Neurosurgery, Tang Du Hospital, The Fourth Military University, Xi’an, China
- 1 Department of Neurosurgery, Tang Du Hospital, The Fourth Military University, Xi’an, China
- 2 Department of Clinical Laboratory and Research center of Tang Du Hospital, The Forth Military Medical University; Xi’an, China
- 3 Department of Neurosurgery, Tang Du Hospital, The Fourth Military University, Xi’an, China
- 4
Journal of Cancer Therapy·Volume 01 (2010)·Pages 29–30·Published 24 March 2010·DOI10.4236/jct.2010.11004
Copy link · social · email
Abstract
Here we propose that the rejuvenation of leukocytes with iPSC technology in vitro and transfusion of cancer cellresistant white blood cells back to human body provide a prospective therapy for cancer patients.
KeywordsIpscsLeukocytesCancer
- A. E. Moore, C. P. Rhoads, and C. M. Southam, “Homotransplantation of human cell lines,” Science, Vol. 125, No. 3239, pp. 158–160, 1957.
- J. M. Pawelek and A. K. Chakraborty, “The cancer cell-leukocyte fusion theory of metastasis,” Advances in Cancer Research, Vol. 101, pp. 397–444. 2008.
- A. M. Hicks, G. Riedlinger, M. C. Willingham, M. A. Alexander-Miller, C. Von Kap-Herr, M. J. Pettenati, A. M. Sanders, H. M. Weir, W. Du, J. Kim, et al., “Transferable anticancer innate immunity in spontaneous regression/complete resistance mice,” Proceedings of the National Academy of Science, USA, Vol. 103, No. 20, pp. 7753–7758, 2006.
- J. Yu, M. A. Vodyanik, K. Smuga-Otto, J. Antosiewicz-Bourget, J. L. Frane, S. Tian, J. Nie, G. A. Jonsdottir, V. Ruotti, R. Stewart, et al., “Induced pluripotent stem cell lines derived from human somatic cells,” Science, Vol. 318, No. 5858, pp. 1917–1920, 2007.
- K. Takahashi, K. Tanabe, M. Ohnuki, M. Narita, T. Ichisaka, K. Tomoda, and S. Yamanaka, “Induction of pluripotent stem cells from adult human fibroblasts by defined factors,” Cell, Vol. 131, No. 5, pp. 861–872, 2007.
- G. Amabile and A. Meissner, “Induced pluripotent stem cells: Current progress and potential for regenerative medicine,” Trends in Molecular Medicine, Vol. 15, No. 2, pp. 59–68, 2009.
- D. Kim, C. H. Kim, J. I. Moon, Y. G. Chung, M. Y. Chang, B. S. Han, S. Ko, E. Yang, K. Y. Cha, R. Lanza, et al., “Generation of human induced pluripotent stem cells by direct delivery of reprogramming proteins,” Cell Stem Cell, Vol. 4, No. 6, pp. 472–476, 2009.
- H. Zhou, S. Wu, J. Y. Joo, S. Zhu, D. W. Han, T. Lin, S. Trauger, G. Bien, S. Yao, Y. Zhu, et al., “Generation of induced pluripotent stem cells using recombinant proteins,” Cell Stem Cell, Vol. 4, No. 5, pp. 381–384, 2009.
- T. Lin, R. Ambasudhan, X. Yuan, W. Li, S. Hilcove, R. Abujarour, X. Lin, H. S. Hahm, E. Hao, A. Hayek, et al., “A chemical platform for improved induction of human iPSCs,” Nature Methods, Vol. 6, No. 11, pp. 805–808, 2009.
- Y. Shi, Y. ZHao, and H. Deng, “Powering reprogramming with vitamin C,” Cell Stem Cell, Vol. 6, pp.1–2, 2010.
- M. A. Esteban, T. Wang, B. Qin, J. Yang, D. Qin, J. Cai, W. Li, Z. Weng, J. Chen, S. Ni, et al., “Vitamin C Enhances the Generation of Mouse and Human Induced Pluripotent Stem Cells,” Cell Stem Cell, 2009.
- J. M. Pawelek and A. K. Chakraborty, “Fusion of tumour cells with bone marrow-derived cells: A unifying explanation for metastasis,” Nature Reviews Cancer, Vol. 8, No. 5, pp. 377–386, 2008.